Human adipose tissue macrophages display activation of cancer-related pathways.
ATM link obesity and cancer?
Document type :
Compte-rendu et recension critique d'ouvrage
DOI :
PMID :
Title :
Human adipose tissue macrophages display activation of cancer-related pathways.
ATM link obesity and cancer?
ATM link obesity and cancer?
Author(s) :
Mayi, Therese Hervee [Auteur]
Récepteurs nucléaires, maladies cardiovasculaires et diabète - U 1011 [RNMCD]
Daoudi, Mehdi [Auteur]
Récepteurs nucléaires, maladies cardiovasculaires et diabète - U 1011 [RNMCD]
Derudas, Bruno [Auteur]
Récepteurs nucléaires, maladies cardiovasculaires et diabète - U 1011 [RNMCD]
Gross, Barbara [Auteur]
Récepteurs nucléaires, maladies cardiovasculaires et diabète - U 1011 [RNMCD]
Bories, Gael [Auteur]
Récepteurs nucléaires, maladies cardiovasculaires et diabète - U 1011 [RNMCD]
Wouters, Kristiaan [Auteur]
Récepteurs nucléaires, maladies cardiovasculaires et diabète - U 1011 [RNMCD]
Brozek, John [Auteur]
Caiazzo, Robert [Auteur]
Thérapie cellulaire du diabète
Service de chirurgie générale et endocrinienne
Raverdi, Violeta [Auteur]
Thérapie cellulaire du diabète
Pigeyre, Marie [Auteur]
Thérapie cellulaire du diabète
Allavena, Paola [Auteur]
Mantovani, Alberto [Auteur]
Pattou, Francois [Auteur]
Thérapie cellulaire du diabète
Service de chirurgie générale et endocrinienne
Staels, Bart [Auteur correspondant]
Récepteurs nucléaires, maladies cardiovasculaires et diabète - U 1011 [RNMCD]
Chinetti-Gbaguidi, Giulia [Auteur]
Récepteurs nucléaires, maladies cardiovasculaires et diabète - U 1011 [RNMCD]
Récepteurs nucléaires, maladies cardiovasculaires et diabète - U 1011 [RNMCD]
Daoudi, Mehdi [Auteur]
Récepteurs nucléaires, maladies cardiovasculaires et diabète - U 1011 [RNMCD]
Derudas, Bruno [Auteur]
Récepteurs nucléaires, maladies cardiovasculaires et diabète - U 1011 [RNMCD]
Gross, Barbara [Auteur]
Récepteurs nucléaires, maladies cardiovasculaires et diabète - U 1011 [RNMCD]
Bories, Gael [Auteur]
Récepteurs nucléaires, maladies cardiovasculaires et diabète - U 1011 [RNMCD]
Wouters, Kristiaan [Auteur]
Récepteurs nucléaires, maladies cardiovasculaires et diabète - U 1011 [RNMCD]
Brozek, John [Auteur]
Caiazzo, Robert [Auteur]
Thérapie cellulaire du diabète
Service de chirurgie générale et endocrinienne
Raverdi, Violeta [Auteur]
Thérapie cellulaire du diabète
Pigeyre, Marie [Auteur]
Thérapie cellulaire du diabète
Allavena, Paola [Auteur]
Mantovani, Alberto [Auteur]
Pattou, Francois [Auteur]
Thérapie cellulaire du diabète
Service de chirurgie générale et endocrinienne
Staels, Bart [Auteur correspondant]
Récepteurs nucléaires, maladies cardiovasculaires et diabète - U 1011 [RNMCD]
Chinetti-Gbaguidi, Giulia [Auteur]
Récepteurs nucléaires, maladies cardiovasculaires et diabète - U 1011 [RNMCD]
Journal title :
Journal of Biological Chemistry
Pages :
21904-13
Publisher :
American Society for Biochemistry and Molecular Biology
Publication date :
2012-06-22
ISSN :
0021-9258
English keyword(s) :
macrophages
obesity
cancer
adipose tissue
chemokines
obesity
cancer
adipose tissue
chemokines
HAL domain(s) :
Sciences du Vivant [q-bio]/Biochimie, Biologie Moléculaire
English abstract : [en]
Obesity is associated with a significantly increased risk for cancer suggesting that adipose tissue dysfunctions might play a crucial role therein. Macrophages play important roles in adipose tissue as well as in cancers. ...
Show more >Obesity is associated with a significantly increased risk for cancer suggesting that adipose tissue dysfunctions might play a crucial role therein. Macrophages play important roles in adipose tissue as well as in cancers. Here, we studied whether human adipose tissue macrophages (ATM) modulate cancer cell function. Therefore, ATM were isolated and compared with monocyte-derived macrophages (MDM) from the same obese patients. ATM, but not MDM, were found to secrete factors inducing inflammation and lipid accumulation in human T47D and HT-29 cancer cells. Gene expression profile comparison of ATM and MDM revealed overexpression of functional clusters, such as cytokine-cytokine receptor interaction (especially CXC-chemokine) signaling as well as cancer-related pathways, in ATM. Comparison with gene expression profiles of human tumor-associated macrophages showed that ATM, but not MDM resemble tumor-associated macrophages. Indirect co-culture experiments demonstrated that factors secreted by preadipocytes, but not mature adipocytes, confer an ATM-like phenotype to MDM. Finally, the concentrations of ATM-secreted factors related to cancer are elevated in serum of obese subjects. In conclusion, ATM may thus modulate the cancer cell phenotype.Show less >
Show more >Obesity is associated with a significantly increased risk for cancer suggesting that adipose tissue dysfunctions might play a crucial role therein. Macrophages play important roles in adipose tissue as well as in cancers. Here, we studied whether human adipose tissue macrophages (ATM) modulate cancer cell function. Therefore, ATM were isolated and compared with monocyte-derived macrophages (MDM) from the same obese patients. ATM, but not MDM, were found to secrete factors inducing inflammation and lipid accumulation in human T47D and HT-29 cancer cells. Gene expression profile comparison of ATM and MDM revealed overexpression of functional clusters, such as cytokine-cytokine receptor interaction (especially CXC-chemokine) signaling as well as cancer-related pathways, in ATM. Comparison with gene expression profiles of human tumor-associated macrophages showed that ATM, but not MDM resemble tumor-associated macrophages. Indirect co-culture experiments demonstrated that factors secreted by preadipocytes, but not mature adipocytes, confer an ATM-like phenotype to MDM. Finally, the concentrations of ATM-secreted factors related to cancer are elevated in serum of obese subjects. In conclusion, ATM may thus modulate the cancer cell phenotype.Show less >
Language :
Anglais
Popular science :
Non
Source :
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