Soluble HLA-G molecules impair natural ...
Document type :
Compte-rendu et recension critique d'ouvrage
DOI :
PMID :
Title :
Soluble HLA-G molecules impair natural killer/dendritic cell crosstalk via inhibition of dendritic cells.
Author(s) :
Gros, Frédéric [Auteur]
Immunologie et chimie thérapeutiques [ICT]
Microenvironnement cellulaire et moléculaire des tumeurs
Cabillic, Florian [Auteur]
Service de Cytogénétique et de Biologie Cellulaire
Université de Rennes - Faculté de Médecine [UR Médecine]
Toutirais, Olivier [Auteur]
Université de Rennes - Faculté de Médecine [UR Médecine]
Le Maux, Amélie [Auteur]
Microenvironnement cellulaire et moléculaire des tumeurs
Sebti, Yasmine [Auteur]
Microenvironnement cellulaire et moléculaire des tumeurs
Récepteurs nucléaires, maladies cardiovasculaires et diabète - U 1011 [RNMCD]
Amiot, Laurence [Auteur]
Groupe d'Etude de la Reproduction Chez l'Homme et les Mammiferes [GERHM]
Immunologie et chimie thérapeutiques [ICT]
Microenvironnement cellulaire et moléculaire des tumeurs
Cabillic, Florian [Auteur]
Service de Cytogénétique et de Biologie Cellulaire
Université de Rennes - Faculté de Médecine [UR Médecine]
Toutirais, Olivier [Auteur]
Université de Rennes - Faculté de Médecine [UR Médecine]
Le Maux, Amélie [Auteur]
Microenvironnement cellulaire et moléculaire des tumeurs
Sebti, Yasmine [Auteur]
Microenvironnement cellulaire et moléculaire des tumeurs
Récepteurs nucléaires, maladies cardiovasculaires et diabète - U 1011 [RNMCD]
Amiot, Laurence [Auteur]
Groupe d'Etude de la Reproduction Chez l'Homme et les Mammiferes [GERHM]
Journal title :
European Journal of Immunology
Pages :
742-9
Publisher :
Wiley-VCH Verlag
Publication date :
2008-03
ISSN :
0014-2980
HAL domain(s) :
Sciences du Vivant [q-bio]/Immunologie
English abstract : [en]
HLA-G molecules are known to exert immunosuppressive action on DC maturation and on NK cells, and can in consequence inhibit respectively T cell responses and NK cytolysis. In this study, we show that monocyte-derived DC, ...
Show more >HLA-G molecules are known to exert immunosuppressive action on DC maturation and on NK cells, and can in consequence inhibit respectively T cell responses and NK cytolysis. In this study, we show that monocyte-derived DC, differentiated in the presence of GM-CSF and IL-4, are sensitive to soluble (s) HLA-G molecules during LPS/IFN-gamma maturation as demonstrated by the decrease of CD80 and HLA-DR expressions and IL-12 secretion. Moreover, DC pretreated with sHLA-G were found to activate NK/DC crosstalk less than non-treated DC. Early activation of NK cells co-cultured with autologous DC was diminished as assessed by CD69 expression. The IFN-gamma production was impaired whereas a slight inhibition of the NK cell cytotoxicity against Daudi cell line was observed. Since sHLA-G is expressed in grafts or sites of tumour proliferation, its indirect action on NK cells via DC could constitute a pathway of early inhibition for both innate and specific immune responses.Show less >
Show more >HLA-G molecules are known to exert immunosuppressive action on DC maturation and on NK cells, and can in consequence inhibit respectively T cell responses and NK cytolysis. In this study, we show that monocyte-derived DC, differentiated in the presence of GM-CSF and IL-4, are sensitive to soluble (s) HLA-G molecules during LPS/IFN-gamma maturation as demonstrated by the decrease of CD80 and HLA-DR expressions and IL-12 secretion. Moreover, DC pretreated with sHLA-G were found to activate NK/DC crosstalk less than non-treated DC. Early activation of NK cells co-cultured with autologous DC was diminished as assessed by CD69 expression. The IFN-gamma production was impaired whereas a slight inhibition of the NK cell cytotoxicity against Daudi cell line was observed. Since sHLA-G is expressed in grafts or sites of tumour proliferation, its indirect action on NK cells via DC could constitute a pathway of early inhibition for both innate and specific immune responses.Show less >
Language :
Anglais
Popular science :
Non
Source :