Titre :

Genetic underpinnings in Alzheimer's disease - a review

Auteur(s) :

Moustafa, Ahmed A. [Auteur]
Hassan, Mubashir [Auteur]
Hewedi, Doaa H. [Auteur]
Hewedi, Iman [Auteur]
Garami, Julia K. [Auteur]
Al Ashwal, Hany [Auteur]
Zaki, Nazar [Auteur]
Seo, Sung-Yum [Auteur]
Cutsuridis, Vassilis [Auteur]
Angulo, Sergio L. [Auteur]
Natesh, Joman Y. [Auteur]
Herzallah, Mohammad M. [Auteur]
Frydecka, Dorota [Auteur]
Misiak, Błażej [Auteur]
Salama, Mohamed [Auteur]
Mohamed, Wael [Auteur]
El Haj, Mohamad [Auteur]
Laboratoire Sciences Cognitives et Sciences Affectives - UMR 9193 [SCALab]
Hornberger, Michael [Auteur]

Titre de la revue :

Reviews in the Neurosciences

Nom court de la revue :

Rev Neurosci

Numéro :

29

Pagination :

21-38

Date de publication :

2017-09-26

ISSN :

0334-1763

Discipline(s) HAL :

Sciences cognitives

Résumé en anglais : [en]

In this review, we discuss the genetic etiologies of Alzheimer's disease (AD). Furthermore, we review genetic links to protein signaling pathways as novel pharmacological targets to treat AD. Moreover, we also discuss the ...
Lire la suite >In this review, we discuss the genetic etiologies of Alzheimer's disease (AD). Furthermore, we review genetic links to protein signaling pathways as novel pharmacological targets to treat AD. Moreover, we also discuss the clumps of AD-m ediated genes according to their single nucleotide polymorphism mutations. Rigorous data mining approaches justified the significant role of genes in AD prevalence. Pedigree analysis and twin studies suggest that genetic components are part of the etiology, rather than only being risk factors for AD. The first autosomal dominant mutation in the amyloid precursor protein (APP) gene was described in 1991. Later, AD was also associated with mutated early-onset (presenilin 1/2, PSEN1/2 and APP) and late-onset (apolipoprotein E, ApoE) genes. Genome-wide association and linkage analysis studies with identified multiple genomic areas have implications for the treatment of AD. We conclude this review with future directions and clinical implications of genetic research in AD.Lire moins >

Langue :

Anglais

Audience :

Non spécifiée

Établissement(s) :

Université de Lille
CNRS
CHU Lille

Collections :

• Sciences Cognitives et Sciences Affectives (SCALab) - UMR 9193

Date de dépôt :

2019-02-13T14:17:46Z
2020-02-06T08:41:32Z