Chronic bace-1 inhibitor administration ...
Document type :
Article dans une revue scientifique: Article original
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Title :
Chronic bace-1 inhibitor administration in tastpm mice (app km670/671nl and psen1 m146v mutation): an eeg study
Author(s) :
Lopez, Susanna [Auteur]
Università degli Studi di Roma "La Sapienza" = Sapienza University [Rome] [UNIROMA]
Del Percio, Claudio [Auteur]
Università degli Studi di Roma "La Sapienza" = Sapienza University [Rome] [UNIROMA]
Forloni, Gianluigi [Auteur]
IRCCS Istituto Nazionale dei Tumori [Milano]
Frasca, Angelisa [Auteur]
IRCCS Istituto Nazionale dei Tumori [Milano]
Drinkenburg, Wilhelmus H. [Auteur]
Janssen Pharmaceutica [Beerse]
Lizio, Roberta [Auteur]
IRCCS Istituto Nazionale dei Tumori [Milano]
Noce, Giuseppe [Auteur]
IRCCS Istituto Nazionale dei Tumori [Milano]
Ferri, Raffaele [Auteur]
Soricelli, Andrea [Auteur]
Stocchi, Fabrizio [Auteur]
Istituto di Ricovero e Cura a Carattere Scientifico [IRCCS San Raffaele Pisana]
Vacca, Laura [Auteur]
Istituto di Ricovero e Cura a Carattere Scientifico [IRCCS San Raffaele Pisana]
Bordet, Regis [Auteur]
Lille Neurosciences & Cognition (LilNCog) - U 1172
Richardson, Jill C. [Auteur]
GlaxoSmithKline [Stevenage, UK] [GSK]
Babiloni, Claudio [Auteur]
Università degli Studi di Roma "La Sapienza" = Sapienza University [Rome] [UNIROMA]
Università degli Studi di Roma "La Sapienza" = Sapienza University [Rome] [UNIROMA]
Del Percio, Claudio [Auteur]
Università degli Studi di Roma "La Sapienza" = Sapienza University [Rome] [UNIROMA]
Forloni, Gianluigi [Auteur]
IRCCS Istituto Nazionale dei Tumori [Milano]
Frasca, Angelisa [Auteur]
IRCCS Istituto Nazionale dei Tumori [Milano]
Drinkenburg, Wilhelmus H. [Auteur]
Janssen Pharmaceutica [Beerse]
Lizio, Roberta [Auteur]
IRCCS Istituto Nazionale dei Tumori [Milano]
Noce, Giuseppe [Auteur]
IRCCS Istituto Nazionale dei Tumori [Milano]
Ferri, Raffaele [Auteur]
Soricelli, Andrea [Auteur]
Stocchi, Fabrizio [Auteur]
Istituto di Ricovero e Cura a Carattere Scientifico [IRCCS San Raffaele Pisana]
Vacca, Laura [Auteur]
Istituto di Ricovero e Cura a Carattere Scientifico [IRCCS San Raffaele Pisana]
Bordet, Regis [Auteur]
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Lille Neurosciences & Cognition (LilNCog) - U 1172
Richardson, Jill C. [Auteur]
GlaxoSmithKline [Stevenage, UK] [GSK]
Babiloni, Claudio [Auteur]
Università degli Studi di Roma "La Sapienza" = Sapienza University [Rome] [UNIROMA]
Journal title :
International journal of molecular sciences
Abbreviated title :
Int J Mol Sci
Volume number :
21
Pages :
9072
Publisher :
MDPI
Publication date :
2020-11-28
ISSN :
1422-0067
Keyword(s) :
electroencephalography (EEG)
-site amyloid precursor protein cleaving enzyme (BACE-1) inhibitor
s disease (AD)
Alzheimer’
β
TASTPM mice
-site amyloid precursor protein cleaving enzyme (BACE-1) inhibitor
s disease (AD)
Alzheimer’
β
TASTPM mice
HAL domain(s) :
Sciences du Vivant [q-bio]
English abstract : [en]
Objective. In this exploratory study, we tested whether electroencephalographic (EEG) rhythms may reflect the effects of a chronic administration (4 weeks) of an anti-amyloid β-site amyloid precursor protein (APP) cleaving ...
Show more >Objective. In this exploratory study, we tested whether electroencephalographic (EEG) rhythms may reflect the effects of a chronic administration (4 weeks) of an anti-amyloid β-site amyloid precursor protein (APP) cleaving enzyme 1 inhibitor (BACE-1; ER-901356; Eisai Co., Ltd., Tokyo, Japan) in TASTPM (double mutation in APP KM670/671NL and PSEN1 M146V) producing Alzheimer’s disease (AD) amyloid neuropathology as compared to wild type (WT) mice. Methods. Ongoing EEG rhythms were recorded from a bipolar frontoparietal and two monopolar frontomedial (prelimbic) and hippocampal channels in 11 WT Vehicle, 10 WT BACE-1, 10 TASTPM Vehicle, and 11 TASTPM BACE-1 mice (males; aged 8/9 months old at the beginning of treatment). Normalized EEG power (density) was compared between the first day (Day 0) and after 4 weeks (Week 4) of the BACE-1 inhibitor (10 mg/Kg) or vehicle administration in the 4 mouse groups. Frequency and magnitude of individual EEG delta and theta frequency peaks (IDF and ITF) were considered during animal conditions of behaviorally passive and active wakefulness. Cognitive status was not tested. Results. Compared with the WT group, the TASTPM group generally showed a significantly lower reactivity in frontoparietal ITF power during the active over the passive condition (p < 0.05). Notably, there was no other statistically significant effect (e.g., additional electrodes, recording time, and BACE-1 inhibitor). Conclusions. The above EEG biomarkers reflected differences between the WT and TASTPM groups, but no BACE-1 inhibitor effect. The results suggest an enhanced experimental design with the use of younger mice, longer drug administrations, an effective control drug, and neuropathological amyloid markers.Show less >
Show more >Objective. In this exploratory study, we tested whether electroencephalographic (EEG) rhythms may reflect the effects of a chronic administration (4 weeks) of an anti-amyloid β-site amyloid precursor protein (APP) cleaving enzyme 1 inhibitor (BACE-1; ER-901356; Eisai Co., Ltd., Tokyo, Japan) in TASTPM (double mutation in APP KM670/671NL and PSEN1 M146V) producing Alzheimer’s disease (AD) amyloid neuropathology as compared to wild type (WT) mice. Methods. Ongoing EEG rhythms were recorded from a bipolar frontoparietal and two monopolar frontomedial (prelimbic) and hippocampal channels in 11 WT Vehicle, 10 WT BACE-1, 10 TASTPM Vehicle, and 11 TASTPM BACE-1 mice (males; aged 8/9 months old at the beginning of treatment). Normalized EEG power (density) was compared between the first day (Day 0) and after 4 weeks (Week 4) of the BACE-1 inhibitor (10 mg/Kg) or vehicle administration in the 4 mouse groups. Frequency and magnitude of individual EEG delta and theta frequency peaks (IDF and ITF) were considered during animal conditions of behaviorally passive and active wakefulness. Cognitive status was not tested. Results. Compared with the WT group, the TASTPM group generally showed a significantly lower reactivity in frontoparietal ITF power during the active over the passive condition (p < 0.05). Notably, there was no other statistically significant effect (e.g., additional electrodes, recording time, and BACE-1 inhibitor). Conclusions. The above EEG biomarkers reflected differences between the WT and TASTPM groups, but no BACE-1 inhibitor effect. The results suggest an enhanced experimental design with the use of younger mice, longer drug administrations, an effective control drug, and neuropathological amyloid markers.Show less >
Language :
Anglais
Audience :
Internationale
Popular science :
Non
Administrative institution(s) :
CHU Lille
Inserm
Université de Lille
Inserm
Université de Lille
Collections :
Research team(s) :
Troubles cognitifs dégénératifs et vasculaires
Submission date :
2021-06-23T13:48:47Z
2022-11-16T09:22:19Z
2022-11-16T09:22:19Z
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