Impaired Functional T-Cell Response to ...
Type de document :
Compte-rendu et recension critique d'ouvrage
PMID :
Titre :
Impaired Functional T-Cell Response to SARS-CoV-2 After Two Doses of BNT162b2 mRNA Vaccine in Older People
Auteur(s) :
Demaret, Julie [Auteur]
Institute for Translational Research in Inflammation - U 1286 [INFINITE (Ex-Liric)]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Corroyer-Simovic, Bénédicte [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Alidjinou, E. K. [Auteur]
Laboratoire de Virologie - ULR 3610 [Laboratoire de Virologie]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Goffard, Anne [Auteur]
Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL]
Trauet, Jacques [Auteur]
Institute for Translational Research in Inflammation - U 1286 [INFINITE (Ex-Liric)]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Miczek, S. [Auteur]
Impact de l'environnement chimique sur la santé humaine - ULR 4483 [IMPECS]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Vuotto, F. [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Dendooven, Arnaud [Auteur]
Institute for Translational Research in Inflammation - U 1286 [INFINITE (Ex-Liric)]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Huvent-Grelle, D. [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Podvin, J. [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Dreuil, D. [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Faure, Karine [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Deplanque, Dominique [Auteur]
Centre d'Investigation Clinique - Innovation Technologique de Lille - CIC 1403 - CIC 9301 [CIC Lille]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Bocket, L. [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Laboratoire de Virologie - ULR 3610 [Laboratoire de Virologie]
Duhamel, A. [Auteur]
Santé Publique : épidémiologie et qualité des soins [EA 2694]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Labreuche, J. [Auteur]
Santé Publique : épidémiologie et qualité des soins [EA 2694]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Sobaszek, A. [Auteur]
Impact de l'environnement chimique sur la santé humaine - ULR 4483 [IMPECS]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Hisbergues, M. [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Université de Lille
Puisieux, F. [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Labalette, Myriam [Auteur]
Institute for Translational Research in Inflammation - U 1286 [INFINITE (Ex-Liric)]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Lefevre, Guillaume [Auteur]
Institute for Translational Research in Inflammation - U 1286 [INFINITE (Ex-Liric)]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Institute for Translational Research in Inflammation - U 1286 [INFINITE (Ex-Liric)]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Corroyer-Simovic, Bénédicte [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Alidjinou, E. K. [Auteur]
Laboratoire de Virologie - ULR 3610 [Laboratoire de Virologie]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Goffard, Anne [Auteur]
Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL]
Trauet, Jacques [Auteur]
Institute for Translational Research in Inflammation - U 1286 [INFINITE (Ex-Liric)]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Miczek, S. [Auteur]
Impact de l'environnement chimique sur la santé humaine - ULR 4483 [IMPECS]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Vuotto, F. [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Dendooven, Arnaud [Auteur]
Institute for Translational Research in Inflammation - U 1286 [INFINITE (Ex-Liric)]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Huvent-Grelle, D. [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Podvin, J. [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Dreuil, D. [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Faure, Karine [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Deplanque, Dominique [Auteur]
Centre d'Investigation Clinique - Innovation Technologique de Lille - CIC 1403 - CIC 9301 [CIC Lille]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Bocket, L. [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Laboratoire de Virologie - ULR 3610 [Laboratoire de Virologie]
Duhamel, A. [Auteur]
Santé Publique : épidémiologie et qualité des soins [EA 2694]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Labreuche, J. [Auteur]
Santé Publique : épidémiologie et qualité des soins [EA 2694]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Sobaszek, A. [Auteur]
Impact de l'environnement chimique sur la santé humaine - ULR 4483 [IMPECS]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Hisbergues, M. [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Université de Lille
Puisieux, F. [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Labalette, Myriam [Auteur]
Institute for Translational Research in Inflammation - U 1286 [INFINITE (Ex-Liric)]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Lefevre, Guillaume [Auteur]
Institute for Translational Research in Inflammation - U 1286 [INFINITE (Ex-Liric)]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Titre de la revue :
Frontiers in immunology
Pagination :
Article 778679
Éditeur :
Frontiers
Date de publication :
2021-12-12
ISSN :
1664-3224
Mot(s)-clé(s) :
mRNA vaccination
T cells response
older people and ageing
vaccine
SARS - CoV - 2
T cells response
older people and ageing
vaccine
SARS - CoV - 2
Discipline(s) HAL :
Sciences du Vivant [q-bio]
Résumé en anglais : [en]
Long-term care facility (LTCF) older residents display physiological alterations of cellular and humoral immunity that affect vaccine responses. Preliminary reports suggested a low early postvaccination antibody response ...
Lire la suite >Long-term care facility (LTCF) older residents display physiological alterations of cellular and humoral immunity that affect vaccine responses. Preliminary reports suggested a low early postvaccination antibody response against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The aim of this study was to focus on the specific T-cell response. We quantified S1-specific IgG, neutralizing antibody titers, total specific IFNγ-secreting T cells by ELISpot, and functionality of CD4+- and CD8+-specific T cells by flow cytometry, after two doses of the BNT162b2 vaccine in younger and older people, with and without previous COVID-19 infection (hereafter referred to as COVID-19-recovered and COVID-19-naive subjects, respectively). Frailty, nutritional, and immunosenescence parameters were collected at baseline in COVID-19-naive older people. We analyzed the immune response in 129 young adults (median age 44.0 years) and 105 older residents living in a LCTF (median age 86.5 years), 3 months after the first injection. Humoral and cellular memory responses were dramatically impaired in the COVID-19-naive older (n = 54) compared with the COVID-19-naive younger adults (n = 121). Notably, older participants’ neutralizing antibodies were 10 times lower than the younger’s antibody titers (p < 0.0001) and LCTF residents also had an impaired functional T-cell response: the frequencies of IFNγ+ and IFNγ+IL-2+TNFα+ cells among specific CD4+ T cells, and the frequency of specific CD8+ T cells were lower in COVID-19-naive older participants than in COVID-19-naive young adults (p < 0.0001 and p = 0.0018, respectively). However, COVID-19-recovered older participants (n = 51) had greater antibody and T-cell responses, including IFNγ+ and IFNγ+IL-2+TNFα+-specific CD4+ T cells (p < 0.0001), as well as TNFα+-specific CD8+ T cells (p < 0.001), than COVID-19-naive older adults. We also observed that “inflammageing” and particularly high plasma levels of TNFα was associated to poor antibody response in the older participants. In conclusion, our results show that the COVID-19-naive older people had low counts and impaired specific CD4+ and CD8+ T cells, in addition to impaired antibody response, and that specific studies are warranted to assess the efficiency of SARS-CoV-2 mRNA-based vaccines, as in other immunocompromised subjects. Our study also shows that, despite their physiological alterations of immunity, vaccination is highly efficient in boosting the prior natural memory response in COVID-19-recovered older people.Lire moins >
Lire la suite >Long-term care facility (LTCF) older residents display physiological alterations of cellular and humoral immunity that affect vaccine responses. Preliminary reports suggested a low early postvaccination antibody response against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The aim of this study was to focus on the specific T-cell response. We quantified S1-specific IgG, neutralizing antibody titers, total specific IFNγ-secreting T cells by ELISpot, and functionality of CD4+- and CD8+-specific T cells by flow cytometry, after two doses of the BNT162b2 vaccine in younger and older people, with and without previous COVID-19 infection (hereafter referred to as COVID-19-recovered and COVID-19-naive subjects, respectively). Frailty, nutritional, and immunosenescence parameters were collected at baseline in COVID-19-naive older people. We analyzed the immune response in 129 young adults (median age 44.0 years) and 105 older residents living in a LCTF (median age 86.5 years), 3 months after the first injection. Humoral and cellular memory responses were dramatically impaired in the COVID-19-naive older (n = 54) compared with the COVID-19-naive younger adults (n = 121). Notably, older participants’ neutralizing antibodies were 10 times lower than the younger’s antibody titers (p < 0.0001) and LCTF residents also had an impaired functional T-cell response: the frequencies of IFNγ+ and IFNγ+IL-2+TNFα+ cells among specific CD4+ T cells, and the frequency of specific CD8+ T cells were lower in COVID-19-naive older participants than in COVID-19-naive young adults (p < 0.0001 and p = 0.0018, respectively). However, COVID-19-recovered older participants (n = 51) had greater antibody and T-cell responses, including IFNγ+ and IFNγ+IL-2+TNFα+-specific CD4+ T cells (p < 0.0001), as well as TNFα+-specific CD8+ T cells (p < 0.001), than COVID-19-naive older adults. We also observed that “inflammageing” and particularly high plasma levels of TNFα was associated to poor antibody response in the older participants. In conclusion, our results show that the COVID-19-naive older people had low counts and impaired specific CD4+ and CD8+ T cells, in addition to impaired antibody response, and that specific studies are warranted to assess the efficiency of SARS-CoV-2 mRNA-based vaccines, as in other immunocompromised subjects. Our study also shows that, despite their physiological alterations of immunity, vaccination is highly efficient in boosting the prior natural memory response in COVID-19-recovered older people.Lire moins >
Langue :
Anglais
Vulgarisation :
Non
Source :
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