Characterization of a Family of Scorpion ...
Type de document :
Compte-rendu et recension critique d'ouvrage
DOI :
PMID :
Titre :
Characterization of a Family of Scorpion Toxins Modulating Ca2+-Activated Cl− Current in Vascular Myocytes
Auteur(s) :
Morel, Jean-Luc [Auteur correspondant]
Institut de Neurosciences cognitives et intégratives d'Aquitaine [INCIA]
Mokrzycki, Nathalie [Auteur]
Institut Pasteur de Lille
Lippens, Guy [Auteur]
Toulouse Biotechnology Institute [TBI]
Drobecq, Hervé [Auteur]
Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Sautière, Pierre [Auteur]
Chercheur indépendant
Hugues, Michel [Auteur]
Chercheur indépendant
Institut de Neurosciences cognitives et intégratives d'Aquitaine [INCIA]
Mokrzycki, Nathalie [Auteur]
Institut Pasteur de Lille
Lippens, Guy [Auteur]
Toulouse Biotechnology Institute [TBI]
Drobecq, Hervé [Auteur]
Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Sautière, Pierre [Auteur]
Chercheur indépendant
Hugues, Michel [Auteur]
Chercheur indépendant
Titre de la revue :
TOXINS
Pagination :
780
Éditeur :
MDPI
Date de publication :
2022
Mot(s)-clé(s) en anglais :
calcium-activated chloride channel
scorpion venom
vascular smooth muscle
animal toxins
scorpion venom
vascular smooth muscle
animal toxins
Discipline(s) HAL :
Sciences du Vivant [q-bio]/Toxicologie
Sciences du Vivant [q-bio]/Sciences pharmaceutiques/Pharmacologie
Sciences du Vivant [q-bio]/Sciences pharmaceutiques/Pharmacologie
Résumé en anglais : [en]
The pharmacology of calcium-activated chloride current is not well developed. Peptides from scorpion venom present potent pharmacological actions on ionic conductance used to characterize the function of channels but can ...
Lire la suite >The pharmacology of calcium-activated chloride current is not well developed. Peptides from scorpion venom present potent pharmacological actions on ionic conductance used to characterize the function of channels but can also be helpful to develop organic pharmacological tools. Using electrophysiological recording coupled with calcium measurement, we tested the potent effect of peptides extracted from Leuirus quinquestratus quinquestratus venom on the calcium-activated chloride current expressed in smooth muscle cells freshly dissociated from rat portal veins. We identified one peptide which selectively inhibited the chloride conductance without effects on either calcium signaling or calcium and potassium currents expressed in this cell type. The synthetic peptide had the same affinity, but the chemical modification of the amino acid sequence altered the efficiency to inhibit the calcium-activated chloride conductanceLire moins >
Lire la suite >The pharmacology of calcium-activated chloride current is not well developed. Peptides from scorpion venom present potent pharmacological actions on ionic conductance used to characterize the function of channels but can also be helpful to develop organic pharmacological tools. Using electrophysiological recording coupled with calcium measurement, we tested the potent effect of peptides extracted from Leuirus quinquestratus quinquestratus venom on the calcium-activated chloride current expressed in smooth muscle cells freshly dissociated from rat portal veins. We identified one peptide which selectively inhibited the chloride conductance without effects on either calcium signaling or calcium and potassium currents expressed in this cell type. The synthetic peptide had the same affinity, but the chemical modification of the amino acid sequence altered the efficiency to inhibit the calcium-activated chloride conductanceLire moins >
Langue :
Anglais
Vulgarisation :
Non
Source :
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