Mapping brain structural differences and ...
Document type :
Article dans une revue scientifique
PMID :
Permalink :
Title :
Mapping brain structural differences and neuroreceptor correlates in Parkinson’s disease visual hallucinations
Author(s) :
Vignando, Miriam [Auteur]
ffytche, Dominic [Auteur]
Lewis, Simon J. G. [Auteur]
Lee, Phil Hyu [Auteur]
Chung, Seok Jong [Auteur]
Weil, Rimona S. [Auteur]
Hu, Michele T. [Auteur]
Mackay, Clare E. [Auteur]
Griffanti, Ludovica [Auteur]
Pins, Delphine [Auteur]
Lille Neurosciences & Cognition (LilNCog) - U 1172
Dujardin, Kathy [Auteur]
Lille Neurosciences & Cognition (LilNCog) - U 1172
Jardri, Renaud [Auteur]
Lille Neurosciences & Cognition (LilNCog) - U 1172
Taylor, John-Paul [Auteur]
Firbank, Michael [Auteur]
McAlonan, Grainne [Auteur]
Mak, Henry K. F. [Auteur]
Ho, Shu Leong [Auteur]
Mehta, Mitul A. [Auteur]
ffytche, Dominic [Auteur]
Lewis, Simon J. G. [Auteur]
Lee, Phil Hyu [Auteur]
Chung, Seok Jong [Auteur]
Weil, Rimona S. [Auteur]
Hu, Michele T. [Auteur]
Mackay, Clare E. [Auteur]
Griffanti, Ludovica [Auteur]
Pins, Delphine [Auteur]
Lille Neurosciences & Cognition (LilNCog) - U 1172
Dujardin, Kathy [Auteur]
Lille Neurosciences & Cognition (LilNCog) - U 1172
Jardri, Renaud [Auteur]
Lille Neurosciences & Cognition (LilNCog) - U 1172
Taylor, John-Paul [Auteur]
Firbank, Michael [Auteur]
McAlonan, Grainne [Auteur]
Mak, Henry K. F. [Auteur]
Ho, Shu Leong [Auteur]
Mehta, Mitul A. [Auteur]
Journal title :
Nature Communications
Abbreviated title :
Nat Commun
Volume number :
13
Publisher :
Springer Science and Business Media LLC
Publication date :
2022-01-26
ISSN :
2041-1723
HAL domain(s) :
Sciences du Vivant [q-bio]
English abstract : [en]
AbstractParkinson’s psychosis (PDP) describes a spectrum of symptoms that may arise in Parkinson’s disease (PD) including visual hallucinations (VH). Imaging studies investigating the neural correlates of PDP have been ...
Show more >AbstractParkinson’s psychosis (PDP) describes a spectrum of symptoms that may arise in Parkinson’s disease (PD) including visual hallucinations (VH). Imaging studies investigating the neural correlates of PDP have been inconsistent in their findings, due to differences in study design and limitations of scale. Here we use empirical Bayes harmonisation to pool together structural imaging data from multiple research groups into a large-scale mega-analysis, allowing us to identify cortical regions and networks involved in VH and their relation to receptor binding. Differences of morphometrics analysed show a wider cortical involvement underlying VH than previously recognised, including primary visual cortex and surrounding regions, and the hippocampus, independent of its role in cognitive decline. Structural covariance analyses point to the involvement of the attentional control networks in PD-VH, while associations with receptor density maps suggest neurotransmitter loss may be linked to the cortical changes.Show less >
Show more >AbstractParkinson’s psychosis (PDP) describes a spectrum of symptoms that may arise in Parkinson’s disease (PD) including visual hallucinations (VH). Imaging studies investigating the neural correlates of PDP have been inconsistent in their findings, due to differences in study design and limitations of scale. Here we use empirical Bayes harmonisation to pool together structural imaging data from multiple research groups into a large-scale mega-analysis, allowing us to identify cortical regions and networks involved in VH and their relation to receptor binding. Differences of morphometrics analysed show a wider cortical involvement underlying VH than previously recognised, including primary visual cortex and surrounding regions, and the hippocampus, independent of its role in cognitive decline. Structural covariance analyses point to the involvement of the attentional control networks in PD-VH, while associations with receptor density maps suggest neurotransmitter loss may be linked to the cortical changes.Show less >
Peer reviewed article :
Oui
Audience :
Non spécifiée
Administrative institution(s) :
Université de Lille
Inserm
CHU Lille
Inserm
CHU Lille
Collections :
Research team(s) :
Troubles cognitifs dégénératifs et vasculaires
Plasticity and Subjectivity (PSY)
Plasticity and Subjectivity (PSY)
Submission date :
2022-11-29T14:55:54Z
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