Prognostic value of the metabolic bulk ...
Type de document :
Compte-rendu et recension critique d'ouvrage
PMID :
Titre :
Prognostic value of the metabolic bulk volume in patients with diffuse large B-cell lymphoma on baseline 18F-FDG PET-CT
Auteur(s) :
Delaby, Gauthier [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Hubaut, Marc-Antoine [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Morschhauser, Franck [Auteur]
Groupe de Recherche sur les formes Injectables et les Technologies Associées - ULR 7365 [GRITA]
Besson, Alix [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Huglo, Damien [Auteur]
Thérapies Assistées par Lasers et Immunothérapies pour l'Oncologie - U 1189 [OncoThAI]
Herbaux, Charles [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Baillet, Clio [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Hubaut, Marc-Antoine [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Morschhauser, Franck [Auteur]
Groupe de Recherche sur les formes Injectables et les Technologies Associées - ULR 7365 [GRITA]
Besson, Alix [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Huglo, Damien [Auteur]
Thérapies Assistées par Lasers et Immunothérapies pour l'Oncologie - U 1189 [OncoThAI]
Herbaux, Charles [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Baillet, Clio [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Titre de la revue :
Leukemia & lymphoma
Pagination :
1584-1591
Éditeur :
Taylor & Francis
Date de publication :
2020-02-29
ISSN :
1042-8194
Mot(s)-clé(s) :
PET-CT
diffuse large B-cell lymphoma
total metabolic tumor volume
metabolic bulk volume
diffuse large B-cell lymphoma
total metabolic tumor volume
metabolic bulk volume
Discipline(s) HAL :
Sciences du Vivant [q-bio]
Résumé en anglais : [en]
We retrospectively investigated the prognostic value of the metabolic bulk volume (MBV), defined as the metabolic volume of the largest lesion, in 106 patients with diffuse large B-cell lymphoma who underwent baseline 18FDG ...
Lire la suite >We retrospectively investigated the prognostic value of the metabolic bulk volume (MBV), defined as the metabolic volume of the largest lesion, in 106 patients with diffuse large B-cell lymphoma who underwent baseline 18FDG PET-CT. Semi-automatically segmented (41% SUVmax) total metabolic tumor volume (TMTV) and MBV underwent receiver operating characteristic analysis, identifying optimal thresholds of 147 cm3 for the TMTV and 41.5 cm3 for the MBV. A low TMTV and a low MBV were significantly associated with longer progression-free survival (PFS) and overall survival (OS). According to Cox multivariate analysis, the TMTV and MBV were independent predictors, respectively, for PFS (HR = 3.501), and OS (HR = 7.242). The TMTV and MBV classification were discordant in 18.9% of patients with a 5-year PFS rate of 100% for patients with low MBV/high TMTV and 74% for high MBV/low TMTV. The baseline MBV can be an efficient tool for the risk stratification of aggressive lymphoma.Lire moins >
Lire la suite >We retrospectively investigated the prognostic value of the metabolic bulk volume (MBV), defined as the metabolic volume of the largest lesion, in 106 patients with diffuse large B-cell lymphoma who underwent baseline 18FDG PET-CT. Semi-automatically segmented (41% SUVmax) total metabolic tumor volume (TMTV) and MBV underwent receiver operating characteristic analysis, identifying optimal thresholds of 147 cm3 for the TMTV and 41.5 cm3 for the MBV. A low TMTV and a low MBV were significantly associated with longer progression-free survival (PFS) and overall survival (OS). According to Cox multivariate analysis, the TMTV and MBV were independent predictors, respectively, for PFS (HR = 3.501), and OS (HR = 7.242). The TMTV and MBV classification were discordant in 18.9% of patients with a 5-year PFS rate of 100% for patients with low MBV/high TMTV and 74% for high MBV/low TMTV. The baseline MBV can be an efficient tool for the risk stratification of aggressive lymphoma.Lire moins >
Langue :
Anglais
Vulgarisation :
Non
Source :