Airway factor XIII associates with type 2 ...
Type de document :
Article dans une revue scientifique: Article original
PMID :
URL permanente :
Titre :
Airway factor XIII associates with type 2 inflammation and airway obstruction in asthmatic patients.
Auteur(s) :
Esnault, Stephane [Auteur]
Kelly, Elizabeth A [Auteur]
Sorkness, Ronald L [Auteur]
Evans, Michael D [Auteur]
Busse, William W [Auteur]
Jarjour, Nizar N [Auteur]
Kelly, Elizabeth A [Auteur]
Sorkness, Ronald L [Auteur]
Evans, Michael D [Auteur]
Busse, William W [Auteur]
Jarjour, Nizar N [Auteur]
Titre de la revue :
The Journal of allergy and clinical immunology
Nom court de la revue :
J Allergy Clin Immunol
Numéro :
137
Pagination :
767-73.e6
Date de publication :
2016-03-01
ISSN :
1097-6825
Mot(s)-clé(s) en anglais :
Adult
Airway Obstruction
Asthma
Biomarkers
Bronchial Provocation Tests
Bronchoalveolar Lavage Fluid
Dendritic Cells
Factor XIII
Female
Gene Expression
Humans
Immunoglobulin E
Male
Middle Aged
RNA, Messenger
Respiratory Function Tests
Severity of Illness Index
Skin Tests
Young Adult
Factor XIII
IL-13
air trapping
airway obstruction
allergy
asthma
eosinophils
inflammation
pulmonary function
severe asthma
Airway Obstruction
Asthma
Biomarkers
Bronchial Provocation Tests
Bronchoalveolar Lavage Fluid
Dendritic Cells
Factor XIII
Female
Gene Expression
Humans
Immunoglobulin E
Male
Middle Aged
RNA, Messenger
Respiratory Function Tests
Severity of Illness Index
Skin Tests
Young Adult
Factor XIII
IL-13
air trapping
airway obstruction
allergy
asthma
eosinophils
inflammation
pulmonary function
severe asthma
Discipline(s) HAL :
Sciences du Vivant [q-bio]
Résumé en anglais : [en]
Coagulation Factor XIII (FXIII) plays an important role in wound healing by stabilizing fibrin clots and cross-linking extracellular matrix proteins. FXIII is expressed in cells of the monocyte/macrophage and dendritic ...
Lire la suite >Coagulation Factor XIII (FXIII) plays an important role in wound healing by stabilizing fibrin clots and cross-linking extracellular matrix proteins. FXIII is expressed in cells of the monocyte/macrophage and dendritic cell lineages in response to type 2 cytokines. We sought to determine the association between FXIII and asthma pathobiology. We analyzed the expression of FXIII mRNA and protein levels in bronchoalveolar lavage samples obtained before and after segmental allergen challenge from patients with mild asthma and in induced sputum samples collected from patients with mild-to-moderate and severe asthma. FXIII mRNA and protein levels were highly upregulated in bronchoalveolar cells and fluid after allergen challenge and mRNA levels correlated with protein levels. In sputum of asthmatic patients, FXIII expression was positively correlated with type 2 immune response and dendritic cell markers (CD209 and CD207). FXIII expression was also associated with increased airflow limitation (FEV1/forced vital capacity and residual volume/total lung capacity ratios) and greater reversibility to β-agonists. FXIII expression was upregulated in the airways of asthmatic patients after allergen exposure. Expression in the sputum of asthmatic patients correlated with the type 2 immune response and airflow limitation. Excessive activity of FXIII could contribute to the pathophysiology of airway obstruction in asthmatic patients.Lire moins >
Lire la suite >Coagulation Factor XIII (FXIII) plays an important role in wound healing by stabilizing fibrin clots and cross-linking extracellular matrix proteins. FXIII is expressed in cells of the monocyte/macrophage and dendritic cell lineages in response to type 2 cytokines. We sought to determine the association between FXIII and asthma pathobiology. We analyzed the expression of FXIII mRNA and protein levels in bronchoalveolar lavage samples obtained before and after segmental allergen challenge from patients with mild asthma and in induced sputum samples collected from patients with mild-to-moderate and severe asthma. FXIII mRNA and protein levels were highly upregulated in bronchoalveolar cells and fluid after allergen challenge and mRNA levels correlated with protein levels. In sputum of asthmatic patients, FXIII expression was positively correlated with type 2 immune response and dendritic cell markers (CD209 and CD207). FXIII expression was also associated with increased airflow limitation (FEV1/forced vital capacity and residual volume/total lung capacity ratios) and greater reversibility to β-agonists. FXIII expression was upregulated in the airways of asthmatic patients after allergen exposure. Expression in the sputum of asthmatic patients correlated with the type 2 immune response and airflow limitation. Excessive activity of FXIII could contribute to the pathophysiology of airway obstruction in asthmatic patients.Lire moins >
Langue :
Anglais
Comité de lecture :
Oui
Audience :
Non spécifiée
Établissement(s) :
Université de Lille
Inserm
CHU Lille
Inserm
CHU Lille
Collections :
Date de dépôt :
2023-10-27T14:45:45Z
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