Impact of AlphaFold on structure prediction ...
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Article dans une revue scientifique: Article original
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Title :
Impact of AlphaFold on structure prediction of protein complexes: The CASP15‐CAPRI experiment
Author(s) :
Lensink, Marc [Auteur]
Unité de Glycobiologie Structurale et Fonctionnelle (UGSF) - UMR 8576
Brysbaert, Guillaume [Auteur]
Unité de Glycobiologie Structurale et Fonctionnelle (UGSF) - UMR 8576
Raouraoua, Nessim [Auteur]
Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576 [UGSF]
Bates, Paul A. [Auteur]
Biomolecular Modelling laboratory [London]
Giulini, Marco [Auteur]
Bijvoet Center for Biomolecular Research [Utrecht]
Honorato, Rodrigo V. [Auteur]
Bijvoet Center for Biomolecular Research [Utrecht]
van Noort, Charlotte [Auteur]
Bijvoet Center for Biomolecular Research [Utrecht]
Teixeira, Joao M. C. [Auteur]
Bijvoet Center for Biomolecular Research [Utrecht]
Bonvin, Alexandre M. J. J. [Auteur]
Bijvoet Center for Biomolecular Research [Utrecht]
Kong, Ren [Auteur]
Jiangsu University of Technology [Changzhou]
Shi, Hang [Auteur]
Jiangsu University of Technology [Changzhou]
Lu, Xufeng [Auteur]
Jiangsu University of Technology [Changzhou]
Chang, Shan [Auteur]
Jiangsu University of Technology [Changzhou]
Liu, Jian [Auteur]
Department of Electrical Engineering and Computer Science [Columbia] [EECS]
Guo, Zhiye [Auteur]
Department of Electrical Engineering and Computer Science [Columbia] [EECS]
Chen, Xiao [Auteur]
Department of Electrical Engineering and Computer Science [Columbia] [EECS]
Morehead, Alex [Auteur]
Department of Electrical Engineering and Computer Science [Columbia] [EECS]
Roy, Raj S. [Auteur]
Department of Electrical Engineering and Computer Science [Columbia] [EECS]
Wu, Tianqi [Auteur]
Department of Electrical Engineering and Computer Science [Columbia] [EECS]
Giri, Nabin [Auteur]
Department of Electrical Engineering and Computer Science [Columbia] [EECS]
Quadir, Farhan [Auteur]
Department of Electrical Engineering and Computer Science [Columbia] [EECS]
Chen, Chen [Auteur]
Department of Electrical Engineering and Computer Science [Columbia] [EECS]
Cheng, Jianlin [Auteur]
Department of Electrical Engineering and Computer Science [Columbia] [EECS]
Del Carpio, Carlos A. [Auteur]
Ichiishi, Eichiro [Auteur]
International University of Health and Welfare Hospital [IUHW Hospital]
Rodriguez‐Lumbreras, Luis A. [Auteur]
Instituto de Ciencias de la Vid y el Vino [ICVV]
Barcelona Supercomputing Center - Centro Nacional de Supercomputacion [BSC-CNS]
Fernandez‐Recio, Juan [Auteur]
Instituto de Ciencias de la Vid y el Vino [ICVV]
Barcelona Supercomputing Center - Centro Nacional de Supercomputacion [BSC-CNS]
Harmalkar, Ameya [Auteur]
Johns Hopkins University [JHU]
Chu, Lee‐Shin [Auteur]
Johns Hopkins University [JHU]
Canner, Sam [Auteur]
Johns Hopkins University [JHU]
Smanta, Rituparna [Auteur]
Johns Hopkins University [JHU]
Gray, Jeffrey J. [Auteur]
Program in Molecular Biophysics [Baltimore]
Johns Hopkins University [JHU]
Li, Hao [Auteur]
Huazhong University of Science and Technology [Wuhan] [HUST]
Lin, Peicong [Auteur]
Huazhong University of Science and Technology [Wuhan] [HUST]
He, Jiahua [Auteur]
Huazhong University of Science and Technology [Wuhan] [HUST]
Tao, Huanyu [Auteur]
Huazhong University of Science and Technology [Wuhan] [HUST]
Huang, Sheng‐You [Auteur]
Huazhong University of Science and Technology [Wuhan] [HUST]
Roel‐Touris, Jorge [Auteur]
Jimenez‐Garcia, Brian [Auteur]
Christoffer, Charles W. [Auteur]
Department of Computer Science [Purdue]
Jain, Anika J. [Auteur]
Department of Biological Sciences [West Lafayette]
Kagaya, Yuki [Auteur]
Department of Biological Sciences [West Lafayette]
Kannan, Harini [Auteur]
Department of Biological Sciences [West Lafayette]
Indian Institute of Technology Madras [IIT Madras]
Nakamura, Tsukasa [Auteur]
Department of Biological Sciences [West Lafayette]
Terashi, Genki [Auteur]
Department of Biological Sciences [West Lafayette]
Verburgt, Jacob C. [Auteur]
Department of Biological Sciences [West Lafayette]
Zhang, Yuanyuan [Auteur]
Department of Computer Science [Purdue]
Zhang, Zicong [Auteur]
Department of Computer Science [Purdue]
Fujuta, Hayato [Auteur]
Indian Institute of Technology Madras [IIT Madras]
Sekijima, Masakazu [Auteur]
Tokyo Institute of Technology [Tokyo] [TITECH]
Kihara, Daisuke [Auteur]
Department of Biological Sciences [West Lafayette]
Department of Computer Science [Purdue]
Khan, Omeir [Auteur]
Boston University [Boston] [BU]
Kotelnikov, Sergei [Auteur]
Stony Brook University [SUNY] [SBU]
Ghani, Usman [Auteur]
Boston University [Boston] [BU]
Padhorny, Dzmitry [Auteur]
Stony Brook University [SUNY] [SBU]
Beglov, Dmitri [Auteur]
Boston University [Boston] [BU]
Vajda, Sandor [Auteur]
Boston University [Boston] [BU]
Kozakov, Dima [Auteur]
Stony Brook University [SUNY] [SBU]
Negi, Surendra S. [Auteur]
The University of Texas Medical Branch [UTMB]
Ricciardelli, Tiziana [Auteur]
King Abdullah University of Science and Technology [Saudi Arabia] [KAUST]
Barradas‐Bautista, Didier [Auteur]
King Abdullah University of Science and Technology [Saudi Arabia] [KAUST]
Cao, Zhen [Auteur]
King Abdullah University of Science and Technology [Saudi Arabia] [KAUST]
Chawla, Mohit [Auteur]
King Abdullah University of Science and Technology [Saudi Arabia] [KAUST]
Cavallo, Luigi [Auteur]
Università degli Studi di Salerno = University of Salerno [UNISA]
King Abdullah University of Science and Technology [Saudi Arabia] [KAUST]
Oliva, Romina [Auteur]
Università degli Studi di Napoli “Parthenope” = University of Naples [PARTHENOPE]
Yin, Rui [Auteur]
University of Maryland [College Park]
Cheung, Melyssa [Auteur]
University of Maryland [College Park]
Guest, Johnathan D. [Auteur]
University of Maryland [College Park]
Lee, Jessica [Auteur]
University of Maryland [College Park]
Pierce, Brian G. [Auteur]
University of Maryland [College Park]
Shor, Ben [Auteur]
The Hebrew University of Jerusalem [HUJ]
Cohen, Tomer [Auteur]
The Hebrew University of Jerusalem [HUJ]
Halfon, Matan [Auteur]
The Hebrew University of Jerusalem [HUJ]
Schneidman‐Duhovny, Dina [Auteur]
The Hebrew University of Jerusalem [HUJ]
Zhu, Shaowen [Auteur]
Texas A&M University [College Station]
Yin, Rujie [Auteur]
Texas A&M University [College Station]
Sun, Yuanfei [Auteur]
Texas A&M University [College Station]
Shen, Yang [Auteur]
Texas A&M University [College Station]
Maszota‐Zieleniak, Martyna [Auteur]
Bojarski, Krzysztof K. [Auteur]
Lubecka, Emilia A. [Auteur]
Marcisz, Mateusz [Auteur]
Danielsson, Annemarie [Auteur]
Dziadek, Lukasz [Auteur]
Gaardlos, Margrethe [Auteur]
Gieldon, Artur [Auteur]
Liwo, Adam [Auteur]
Samsonov, Sergey A. [Auteur]
Slusarz, Rafal [Auteur]
Zieba, Karolina [Auteur]
Sieradzan, Adam K. [Auteur]
Czaplewski, Cezary [Auteur]
Kobayashi, Shinpei [Auteur]
Kitasato University
Miyakawa, Yuta [Auteur]
Kitasato University
Kiyota, Yasuomi [Auteur]
Kitasato University
Takeda‐Shitaka, Mayuko [Auteur]
Kitasato University
Olechnovic, Kliment [Auteur]
Institute of Biotechnology [Vilnius]
Valancauskas, Lukas [Auteur]
Institute of Biotechnology [Vilnius]
Dapkunas, Justas [Auteur]
Institute of Biotechnology [Vilnius]
Venclovas, Ceslovas [Auteur]
Institute of Biotechnology [Vilnius]
Wallner, Bjorn [Auteur]
Linköping University [LIU]
Yang, Lin [Auteur]
Harbin Institute of Technology [HIT]
The University of Sydney
Hou, Chengyu [Auteur]
Harbin Institute of Technology [HIT]
He, Xiaodong [Auteur]
Harbin Institute of Technology [HIT]
Guo, Shuai [Auteur]
Harbin Institute of Technology [HIT]
Jiang, Shenda [Auteur]
Harbin Institute of Technology [HIT]
Ma, Xiaoliang [Auteur]
Harbin Institute of Technology [HIT]
Duan, Rui [Auteur]
University of Missouri [Columbia] [Mizzou]
Qui, Liming [Auteur]
University of Missouri [Columbia] [Mizzou]
Xu, Xianjin [Auteur]
University of Missouri [Columbia] [Mizzou]
Zou, Xiaoqin [Auteur]
University of Missouri [Columbia] [Mizzou]
Velankar, Sameer [Auteur]
European Bioinformatics Institute [Hinxton] [EMBL-EBI]
Wodak, Shoshana J. [Auteur]
VIB-VUB Center for Structural Biology [Bruxelles]
Unité de Glycobiologie Structurale et Fonctionnelle (UGSF) - UMR 8576
Brysbaert, Guillaume [Auteur]
Unité de Glycobiologie Structurale et Fonctionnelle (UGSF) - UMR 8576
Raouraoua, Nessim [Auteur]
Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576 [UGSF]
Bates, Paul A. [Auteur]
Biomolecular Modelling laboratory [London]
Giulini, Marco [Auteur]
Bijvoet Center for Biomolecular Research [Utrecht]
Honorato, Rodrigo V. [Auteur]
Bijvoet Center for Biomolecular Research [Utrecht]
van Noort, Charlotte [Auteur]
Bijvoet Center for Biomolecular Research [Utrecht]
Teixeira, Joao M. C. [Auteur]
Bijvoet Center for Biomolecular Research [Utrecht]
Bonvin, Alexandre M. J. J. [Auteur]
Bijvoet Center for Biomolecular Research [Utrecht]
Kong, Ren [Auteur]
Jiangsu University of Technology [Changzhou]
Shi, Hang [Auteur]
Jiangsu University of Technology [Changzhou]
Lu, Xufeng [Auteur]
Jiangsu University of Technology [Changzhou]
Chang, Shan [Auteur]
Jiangsu University of Technology [Changzhou]
Liu, Jian [Auteur]
Department of Electrical Engineering and Computer Science [Columbia] [EECS]
Guo, Zhiye [Auteur]
Department of Electrical Engineering and Computer Science [Columbia] [EECS]
Chen, Xiao [Auteur]
Department of Electrical Engineering and Computer Science [Columbia] [EECS]
Morehead, Alex [Auteur]
Department of Electrical Engineering and Computer Science [Columbia] [EECS]
Roy, Raj S. [Auteur]
Department of Electrical Engineering and Computer Science [Columbia] [EECS]
Wu, Tianqi [Auteur]
Department of Electrical Engineering and Computer Science [Columbia] [EECS]
Giri, Nabin [Auteur]
Department of Electrical Engineering and Computer Science [Columbia] [EECS]
Quadir, Farhan [Auteur]
Department of Electrical Engineering and Computer Science [Columbia] [EECS]
Chen, Chen [Auteur]
Department of Electrical Engineering and Computer Science [Columbia] [EECS]
Cheng, Jianlin [Auteur]
Department of Electrical Engineering and Computer Science [Columbia] [EECS]
Del Carpio, Carlos A. [Auteur]
Ichiishi, Eichiro [Auteur]
International University of Health and Welfare Hospital [IUHW Hospital]
Rodriguez‐Lumbreras, Luis A. [Auteur]
Instituto de Ciencias de la Vid y el Vino [ICVV]
Barcelona Supercomputing Center - Centro Nacional de Supercomputacion [BSC-CNS]
Fernandez‐Recio, Juan [Auteur]
Instituto de Ciencias de la Vid y el Vino [ICVV]
Barcelona Supercomputing Center - Centro Nacional de Supercomputacion [BSC-CNS]
Harmalkar, Ameya [Auteur]
Johns Hopkins University [JHU]
Chu, Lee‐Shin [Auteur]
Johns Hopkins University [JHU]
Canner, Sam [Auteur]
Johns Hopkins University [JHU]
Smanta, Rituparna [Auteur]
Johns Hopkins University [JHU]
Gray, Jeffrey J. [Auteur]
Program in Molecular Biophysics [Baltimore]
Johns Hopkins University [JHU]
Li, Hao [Auteur]
Huazhong University of Science and Technology [Wuhan] [HUST]
Lin, Peicong [Auteur]
Huazhong University of Science and Technology [Wuhan] [HUST]
He, Jiahua [Auteur]
Huazhong University of Science and Technology [Wuhan] [HUST]
Tao, Huanyu [Auteur]
Huazhong University of Science and Technology [Wuhan] [HUST]
Huang, Sheng‐You [Auteur]
Huazhong University of Science and Technology [Wuhan] [HUST]
Roel‐Touris, Jorge [Auteur]
Jimenez‐Garcia, Brian [Auteur]
Christoffer, Charles W. [Auteur]
Department of Computer Science [Purdue]
Jain, Anika J. [Auteur]
Department of Biological Sciences [West Lafayette]
Kagaya, Yuki [Auteur]
Department of Biological Sciences [West Lafayette]
Kannan, Harini [Auteur]
Department of Biological Sciences [West Lafayette]
Indian Institute of Technology Madras [IIT Madras]
Nakamura, Tsukasa [Auteur]
Department of Biological Sciences [West Lafayette]
Terashi, Genki [Auteur]
Department of Biological Sciences [West Lafayette]
Verburgt, Jacob C. [Auteur]
Department of Biological Sciences [West Lafayette]
Zhang, Yuanyuan [Auteur]
Department of Computer Science [Purdue]
Zhang, Zicong [Auteur]
Department of Computer Science [Purdue]
Fujuta, Hayato [Auteur]
Indian Institute of Technology Madras [IIT Madras]
Sekijima, Masakazu [Auteur]
Tokyo Institute of Technology [Tokyo] [TITECH]
Kihara, Daisuke [Auteur]
Department of Biological Sciences [West Lafayette]
Department of Computer Science [Purdue]
Khan, Omeir [Auteur]
Boston University [Boston] [BU]
Kotelnikov, Sergei [Auteur]
Stony Brook University [SUNY] [SBU]
Ghani, Usman [Auteur]
Boston University [Boston] [BU]
Padhorny, Dzmitry [Auteur]
Stony Brook University [SUNY] [SBU]
Beglov, Dmitri [Auteur]
Boston University [Boston] [BU]
Vajda, Sandor [Auteur]
Boston University [Boston] [BU]
Kozakov, Dima [Auteur]
Stony Brook University [SUNY] [SBU]
Negi, Surendra S. [Auteur]
The University of Texas Medical Branch [UTMB]
Ricciardelli, Tiziana [Auteur]
King Abdullah University of Science and Technology [Saudi Arabia] [KAUST]
Barradas‐Bautista, Didier [Auteur]
King Abdullah University of Science and Technology [Saudi Arabia] [KAUST]
Cao, Zhen [Auteur]
King Abdullah University of Science and Technology [Saudi Arabia] [KAUST]
Chawla, Mohit [Auteur]
King Abdullah University of Science and Technology [Saudi Arabia] [KAUST]
Cavallo, Luigi [Auteur]
Università degli Studi di Salerno = University of Salerno [UNISA]
King Abdullah University of Science and Technology [Saudi Arabia] [KAUST]
Oliva, Romina [Auteur]
Università degli Studi di Napoli “Parthenope” = University of Naples [PARTHENOPE]
Yin, Rui [Auteur]
University of Maryland [College Park]
Cheung, Melyssa [Auteur]
University of Maryland [College Park]
Guest, Johnathan D. [Auteur]
University of Maryland [College Park]
Lee, Jessica [Auteur]
University of Maryland [College Park]
Pierce, Brian G. [Auteur]
University of Maryland [College Park]
Shor, Ben [Auteur]
The Hebrew University of Jerusalem [HUJ]
Cohen, Tomer [Auteur]
The Hebrew University of Jerusalem [HUJ]
Halfon, Matan [Auteur]
The Hebrew University of Jerusalem [HUJ]
Schneidman‐Duhovny, Dina [Auteur]
The Hebrew University of Jerusalem [HUJ]
Zhu, Shaowen [Auteur]
Texas A&M University [College Station]
Yin, Rujie [Auteur]
Texas A&M University [College Station]
Sun, Yuanfei [Auteur]
Texas A&M University [College Station]
Shen, Yang [Auteur]
Texas A&M University [College Station]
Maszota‐Zieleniak, Martyna [Auteur]
Bojarski, Krzysztof K. [Auteur]
Lubecka, Emilia A. [Auteur]
Marcisz, Mateusz [Auteur]
Danielsson, Annemarie [Auteur]
Dziadek, Lukasz [Auteur]
Gaardlos, Margrethe [Auteur]
Gieldon, Artur [Auteur]
Liwo, Adam [Auteur]
Samsonov, Sergey A. [Auteur]
Slusarz, Rafal [Auteur]
Zieba, Karolina [Auteur]
Sieradzan, Adam K. [Auteur]
Czaplewski, Cezary [Auteur]
Kobayashi, Shinpei [Auteur]
Kitasato University
Miyakawa, Yuta [Auteur]
Kitasato University
Kiyota, Yasuomi [Auteur]
Kitasato University
Takeda‐Shitaka, Mayuko [Auteur]
Kitasato University
Olechnovic, Kliment [Auteur]
Institute of Biotechnology [Vilnius]
Valancauskas, Lukas [Auteur]
Institute of Biotechnology [Vilnius]
Dapkunas, Justas [Auteur]
Institute of Biotechnology [Vilnius]
Venclovas, Ceslovas [Auteur]
Institute of Biotechnology [Vilnius]
Wallner, Bjorn [Auteur]
Linköping University [LIU]
Yang, Lin [Auteur]
Harbin Institute of Technology [HIT]
The University of Sydney
Hou, Chengyu [Auteur]
Harbin Institute of Technology [HIT]
He, Xiaodong [Auteur]
Harbin Institute of Technology [HIT]
Guo, Shuai [Auteur]
Harbin Institute of Technology [HIT]
Jiang, Shenda [Auteur]
Harbin Institute of Technology [HIT]
Ma, Xiaoliang [Auteur]
Harbin Institute of Technology [HIT]
Duan, Rui [Auteur]
University of Missouri [Columbia] [Mizzou]
Qui, Liming [Auteur]
University of Missouri [Columbia] [Mizzou]
Xu, Xianjin [Auteur]
University of Missouri [Columbia] [Mizzou]
Zou, Xiaoqin [Auteur]
University of Missouri [Columbia] [Mizzou]
Velankar, Sameer [Auteur]
European Bioinformatics Institute [Hinxton] [EMBL-EBI]
Wodak, Shoshana J. [Auteur]
VIB-VUB Center for Structural Biology [Bruxelles]
Journal title :
Proteins - Structure, Function and Bioinformatics
Abbreviated title :
Proteins
Publisher :
Wiley
Publication date :
2023-10-31
ISSN :
0887-3585
English keyword(s) :
AlphaFold
blind prediction
CAPRI
CASP
deep learning
protein assemblies
protein complexes
protein-protein interaction
blind prediction
CAPRI
CASP
deep learning
protein assemblies
protein complexes
protein-protein interaction
HAL domain(s) :
Sciences du Vivant [q-bio]
Chimie/Chimie théorique et/ou physique
Chimie/Chimie théorique et/ou physique
English abstract : [en]
We present the results for CAPRI Round 54, the 5th joint CASP‐CAPRI protein assembly prediction challenge. The Round offered 37 targets, including 14 homodimers, 3 homo‐trimers, 13 heterodimers including 3 antibody–antigen ...
Show more >We present the results for CAPRI Round 54, the 5th joint CASP‐CAPRI protein assembly prediction challenge. The Round offered 37 targets, including 14 homodimers, 3 homo‐trimers, 13 heterodimers including 3 antibody–antigen complexes, and 7 large assemblies. On average ~70 CASP and CAPRI predictor groups, including more than 20 automatics servers, submitted models for each target. A total of 21 941 models submitted by these groups and by 15 CAPRI scorer groups were evaluated using the CAPRI model quality measures and the DockQ score consolidating these measures. The prediction performance was quantified by a weighted score based on the number of models of acceptable quality or higher submitted by each group among their five best models. Results show substantial progress achieved across a significant fraction of the 60+ participating groups. High‐quality models were produced for about 40% of the targets compared to 8% two years earlier. This remarkable improvement is due to the wide use of the AlphaFold2 and AlphaFold2‐Multimer software and the confidence metrics they provide. Notably, expanded sampling of candidate solutions by manipulating these deep learning inference engines, enriching multiple sequence alignments, or integration of advanced modeling tools, enabled top performing groups to exceed the performance of a standard AlphaFold2‐Multimer version used as a yard stick. This notwithstanding, performance remained poor for complexes with antibodies and nanobodies, where evolutionary relationships between the binding partners are lacking, and for complexes featuring conformational flexibility, clearly indicating that the prediction of protein complexes remains a challenging problem.Show less >
Show more >We present the results for CAPRI Round 54, the 5th joint CASP‐CAPRI protein assembly prediction challenge. The Round offered 37 targets, including 14 homodimers, 3 homo‐trimers, 13 heterodimers including 3 antibody–antigen complexes, and 7 large assemblies. On average ~70 CASP and CAPRI predictor groups, including more than 20 automatics servers, submitted models for each target. A total of 21 941 models submitted by these groups and by 15 CAPRI scorer groups were evaluated using the CAPRI model quality measures and the DockQ score consolidating these measures. The prediction performance was quantified by a weighted score based on the number of models of acceptable quality or higher submitted by each group among their five best models. Results show substantial progress achieved across a significant fraction of the 60+ participating groups. High‐quality models were produced for about 40% of the targets compared to 8% two years earlier. This remarkable improvement is due to the wide use of the AlphaFold2 and AlphaFold2‐Multimer software and the confidence metrics they provide. Notably, expanded sampling of candidate solutions by manipulating these deep learning inference engines, enriching multiple sequence alignments, or integration of advanced modeling tools, enabled top performing groups to exceed the performance of a standard AlphaFold2‐Multimer version used as a yard stick. This notwithstanding, performance remained poor for complexes with antibodies and nanobodies, where evolutionary relationships between the binding partners are lacking, and for complexes featuring conformational flexibility, clearly indicating that the prediction of protein complexes remains a challenging problem.Show less >
Language :
Anglais
Audience :
Internationale
Popular science :
Non
European Project :
Other project(s) or funding source(s) :
Cancer Research UK. Grant Number: FC0001003
UK Medical Research Council. Grant Number: FC001003
Wellcome Trust. Grant Number: FC001003
Netherlands e-Science Center. Grant Number: 027.020.G13
US National Institutes of Health. Grant Numbers: R01GM146340, R01GM093123
Spanish Ministry of Science. Grant Numbers: 501100011033, AEI/10.13039, PID2019-110167RB-I00
National Institute of Health. Grant Numbers: R35 GM144083, RM1135136, R35GM118078, R01GM140098, R01GM123055, R01GM133840, R35-GM141881
Advanced Research Computing at Hopkins (ARCH) core facility
National Natural Science Foundation of China. Grant Numbers: 32161133002, 62072199
European Molecular Biology Organization (EMBO). Grant Number: ALTF 145-2021
Marie Skłodowska-Curie. Grant Number: 801342
Government of Catalonia's Agency for Business Competitiveness (ACCIO)
National Science Foundation. Grant Numbers: DMS 2054251, DBI2003635, IIS2211598, DBI2146026, MCB1925643, CMMI1825941, IIS1763246, DBI1759934, CCF-1943008, OAC1920103
National Institute of General Medical Sciences. Grant Number: T32 GM132024
NIH/NIGMS. Grant Numbers: R35GM136409, R35GM124952
Research Council of Lithuania. Grant Number: S-MIP-21-25
Wallenberg AI, Autonomous System and Software Program (WASP)
Knut and Alice Wallenberg Foundation (KAW)
Swedish Research Council
Science Foundation of the National Key Laboratory of Science and Technology
UK Medical Research Council. Grant Number: FC001003
Wellcome Trust. Grant Number: FC001003
Netherlands e-Science Center. Grant Number: 027.020.G13
US National Institutes of Health. Grant Numbers: R01GM146340, R01GM093123
Spanish Ministry of Science. Grant Numbers: 501100011033, AEI/10.13039, PID2019-110167RB-I00
National Institute of Health. Grant Numbers: R35 GM144083, RM1135136, R35GM118078, R01GM140098, R01GM123055, R01GM133840, R35-GM141881
Advanced Research Computing at Hopkins (ARCH) core facility
National Natural Science Foundation of China. Grant Numbers: 32161133002, 62072199
European Molecular Biology Organization (EMBO). Grant Number: ALTF 145-2021
Marie Skłodowska-Curie. Grant Number: 801342
Government of Catalonia's Agency for Business Competitiveness (ACCIO)
National Science Foundation. Grant Numbers: DMS 2054251, DBI2003635, IIS2211598, DBI2146026, MCB1925643, CMMI1825941, IIS1763246, DBI1759934, CCF-1943008, OAC1920103
National Institute of General Medical Sciences. Grant Number: T32 GM132024
NIH/NIGMS. Grant Numbers: R35GM136409, R35GM124952
Research Council of Lithuania. Grant Number: S-MIP-21-25
Wallenberg AI, Autonomous System and Software Program (WASP)
Knut and Alice Wallenberg Foundation (KAW)
Swedish Research Council
Science Foundation of the National Key Laboratory of Science and Technology
Administrative institution(s) :
Université de Lille
CNRS
CNRS
Research team(s) :
Computational Molecular Systems Biology
Submission date :
2023-11-07T14:57:26Z
2023-11-10T13:25:28Z
2023-11-10T13:25:28Z
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