Ceftobiprole: a potential empirical ...
Type de document :
Compte-rendu et recension critique d'ouvrage
PMID :
Titre :
Ceftobiprole: a potential empirical post-operative monotherapy in prosthetic joint infections.
Auteur(s) :
Duployez, Claire [Auteur]
Institut de Microbiologie [CHRU Lille]
Wallet, Frederic [Auteur]
Institut de Microbiologie [CHRU Lille]
Migaud, Henri [Auteur]
Marrow Adiposity & Bone Lab - Adiposité Médullaire et Os - ULR 4490 [MABLab (ex-pmoi)]
Senneville, Eric [Auteur]
Evaluation des technologies de santé et des pratiques médicales - ULR 2694 [METRICS]
Loiez, Caroline [Auteur]
Institut de Microbiologie [CHRU Lille]
Institut de Microbiologie [CHRU Lille]
Wallet, Frederic [Auteur]
![refId](/themes/Mirage2//images/idref.png)
Institut de Microbiologie [CHRU Lille]
Migaud, Henri [Auteur]
![refId](/themes/Mirage2//images/idref.png)
Marrow Adiposity & Bone Lab - Adiposité Médullaire et Os - ULR 4490 [MABLab (ex-pmoi)]
Senneville, Eric [Auteur]
![refId](/themes/Mirage2//images/idref.png)
Evaluation des technologies de santé et des pratiques médicales - ULR 2694 [METRICS]
Loiez, Caroline [Auteur]
Institut de Microbiologie [CHRU Lille]
Titre de la revue :
Annals of Clinical Microbiology and Antimicrobials
Pagination :
9
Éditeur :
BioMed Central
Date de publication :
2020-03-28
ISSN :
1476-0711
Mot(s)-clé(s) en anglais :
Prosthetic joint infection
Ceftobiprole
Empirical antibiotic therapy
Bacterial resistance
Ceftobiprole
Empirical antibiotic therapy
Bacterial resistance
Discipline(s) HAL :
Sciences du Vivant [q-bio]
Résumé en anglais : [en]
BackgroundThis study aimed to evaluate in vitro susceptibility to ceftobiprole of clinical strains identified from prosthetic joint infections (PJIs) compared to that of the associations currently recommended for post-operative ...
Lire la suite >BackgroundThis study aimed to evaluate in vitro susceptibility to ceftobiprole of clinical strains identified from prosthetic joint infections (PJIs) compared to that of the associations currently recommended for post-operative empirical antibiotic therapy (PEAT) (vancomycin with either cefepime, third-generation cephalosporin or piperacillin–tazobactam).MethodsWe performed a 1-year retrospective study on all the surgical procedures performed in our hospital for PJI. Susceptibility profiles of all the strains cultured from surgical samples were reviewed to compare ceftobiprole to current used associations.ResultsDuring the study period (from January 2018 to December 2018), we identified 106 patients managed for PJI and a total of 216 surgical interventions. One hundred-fifty strains were identified from intraoperative samples, excluding redundant strains. Staphylococcus spp. represented 52.7% of all strains and Enterobacteriales 13.3%. Twenty-three patients had polymicrobial infection (22%). Among 149 surgical procedures with positive culture results, ceftobiprole covered the bacterial strains in 138 (92.6%) cases. In comparison, this percentage was 94.6% for vancomycin plus cefepime (p = 0.64), 92.6% for vancomycin plus a third-generation cephalosporin in 138 cases (p = 1) and 94.6% for vancomycin plus piperacillin–tazobactam) (p = 0.64).ConclusionBased on antimicrobial susceptibility testing, our results suggest that ceftobiprole could be an interesting option for PEAT in PJIs, allowing the use of a single agent.Lire moins >
Lire la suite >BackgroundThis study aimed to evaluate in vitro susceptibility to ceftobiprole of clinical strains identified from prosthetic joint infections (PJIs) compared to that of the associations currently recommended for post-operative empirical antibiotic therapy (PEAT) (vancomycin with either cefepime, third-generation cephalosporin or piperacillin–tazobactam).MethodsWe performed a 1-year retrospective study on all the surgical procedures performed in our hospital for PJI. Susceptibility profiles of all the strains cultured from surgical samples were reviewed to compare ceftobiprole to current used associations.ResultsDuring the study period (from January 2018 to December 2018), we identified 106 patients managed for PJI and a total of 216 surgical interventions. One hundred-fifty strains were identified from intraoperative samples, excluding redundant strains. Staphylococcus spp. represented 52.7% of all strains and Enterobacteriales 13.3%. Twenty-three patients had polymicrobial infection (22%). Among 149 surgical procedures with positive culture results, ceftobiprole covered the bacterial strains in 138 (92.6%) cases. In comparison, this percentage was 94.6% for vancomycin plus cefepime (p = 0.64), 92.6% for vancomycin plus a third-generation cephalosporin in 138 cases (p = 1) and 94.6% for vancomycin plus piperacillin–tazobactam) (p = 0.64).ConclusionBased on antimicrobial susceptibility testing, our results suggest that ceftobiprole could be an interesting option for PEAT in PJIs, allowing the use of a single agent.Lire moins >
Langue :
Anglais
Vulgarisation :
Non
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