Title :

Outcome of patients with streptococcal prosthetic joint infections with special reference to rifampicin combinations

Author(s) :

Fiaux, E [Auteur]
Service des maladies infectieuses et tropicales [Rouen]
Titecat, Marie [Auteur]
Robineau, O [Auteur]
Centre Hospitalier Gustave Dron [Tourcoing]
Lora-Tamayo, J [Auteur]
Hospital General Universitario "Gregorio Marañón" [Madrid]
El Samad, Youssef [Auteur]
CHU Amiens-Picardie
Etienne, M [Auteur]
Service des maladies infectieuses et tropicales [Rouen]
Frebourg, N [Auteur]
CHU Rouen
Blondiaux, N [Auteur]
Centre Hospitalier Gustave Dron [Tourcoing]
Brunschweiler, B [Auteur]
CHU Amiens-Picardie
Dujardin, F [Auteur]
Université de Rouen Normandie [UNIROUEN]
Beltrand, Eric [Auteur]
Centre Hospitalier Gustave Dron [Tourcoing]
Loiez, Caroline [Auteur]
Université de Lille
Cattoir, Vincent [Auteur]
Université de Caen Normandie [UNICAEN]
Canarelli, J P [Auteur]
Université de Picardie Jules Verne [UPJV]
Hulet, C [Auteur]
Université de Caen Normandie [UNICAEN]
Valette, M [Auteur]
Centre Hospitalier Gustave Dron [Tourcoing]
Nguyen, Son [Auteur]
Centre Hospitalier Gustave Dron [Tourcoing]
Caron, F [Auteur]
Université de Rouen Normandie [UNIROUEN]
Migaud, Henri [Auteur]
Marrow Adiposity & Bone Lab - Adiposité Médullaire et Os - ULR 4490 [MABLab]
Senneville, Eric [Auteur correspondant]
Evaluation des technologies de santé et des pratiques médicales - ULR 2694 [METRICS]

Journal title :

BMC infectious diseases

Pages :

568

Publisher :

BioMed Central

Publication date :

2016

ISSN :

1471-2334

English keyword(s) :

Risk factors
Prosthetic joint infection
Streptococcus spp
Rifampicin
Outcome

HAL domain(s) :

Sciences du Vivant [q-bio]/Médecine humaine et pathologie/Maladies infectieuses
Sciences du Vivant [q-bio]/Sciences pharmaceutiques/Pharmacologie

English abstract : [en]

Background: Outcome of patients with streptococcal prosthetic joint infections (PJIs) is not well known.Methods: We performed a retrospective multicenter cohort study that involved patients with total hip/knee prosthetic ...
Show more >Background: Outcome of patients with streptococcal prosthetic joint infections (PJIs) is not well known.Methods: We performed a retrospective multicenter cohort study that involved patients with total hip/knee prosthetic joint (THP/TKP) infections due to Streptococcus spp. from 2001 through 2009.Results: Ninety-five streptococcal PJI episodes (50 THP and 45 TKP) in 87 patients of mean age 69.1 ± 13.7 years met the inclusion criteria. In all, 55 out of 95 cases (57.9 %) were treated with debridement and retention of the infected implants with antibiotic therapy (DAIR). Rifampicin-combinations, including with levofloxacin, were used in 52 (54.7 %) and 28 (29.5 %) cases, respectively. After a mean follow-up period of 895 days (IQR: 395–1649), the remission rate was 70.5 % (67/95). Patients with PJIs due to S. agalactiae failed in the same proportion as in the other patients (10/37 (27.1 %) versus 19/58 (32.7 %); p = .55). In the univariate analysis, antibiotic monotherapy, DAIR, antibiotic treatments other than rifampicin-combinations, and TKP were all associated with a worse outcome. The only independent variable significantly associated with the patients’ outcomes was the location of the prosthesis (i.e., hip versus knee) (OR = 0.19; 95 % CI 0.04–0.93; p value 0.04).Conclusions: The prognosis of streptococcal PJIs may not be as good as previously reported, especially for patients with an infected total knee arthroplasty. Rifampicin combinations, especially with levofloxacin, appear to be suitable antibiotic regimens for these patients.Show less >

Language :

Anglais

Peer reviewed article :

Oui

Audience :

Internationale

Popular science :

Non

Collections :

• Marrow Adiposity & Bone Lab (MABLab) - ULR 4490

Source :

Harvested from HAL