Genome-wide associations of aortic ...
Type de document :
Compte-rendu et recension critique d'ouvrage
PMID :
Titre :
Genome-wide associations of aortic distensibility suggest causality for aortic aneurysms and brain white matter hyperintensities
Auteur(s) :
Francis, Catherine M. [Auteur]
Imperial College London
Futschik, Matthias E. [Auteur]
Imperial College London
Huang, Jian [Auteur]
Imperial College London
Bai, Wenjia [Auteur]
Imperial College London
Sargurupremraj, Muralidharan [Auteur]
Bordeaux population health [BPH]
Teumer, Alexander [Auteur]
German Center for Cardiovascular Research [DZHK]
University of Medicine Greifswald
Breteler, Monique M. B. [Auteur]
German Research Center for Neurodegenerative Diseases - Deutsches Zentrum für Neurodegenerative Erkrankungen [DZNE]
Petretto, Enrico [Auteur]
National University of Singapore [NUS]
Ho, Amanda S. R. [Auteur]
National University of Singapore [NUS]
Amouyel, Philippe [Auteur]
Facteurs de Risque et Déterminants Moléculaires des Maladies liées au Vieillissement - U 1167 [RID-AGE]
Engelter, Stefan T. [Auteur]
Bulow, Robin [Auteur]
University of Medicine Greifswald
Volker, Uwe [Auteur]
University of Medicine Greifswald
Volzke, Henry [Auteur]
University of Medicine Greifswald
Dorr, Marcus [Auteur]
German Center for Cardiovascular Research [DZHK]
Imtiaz, Mohammed-Aslam [Auteur]
German Research Center for Neurodegenerative Diseases - Deutsches Zentrum für Neurodegenerative Erkrankungen [DZNE]
Aziz, N. Ahmad [Auteur]
German Research Center for Neurodegenerative Diseases - Deutsches Zentrum für Neurodegenerative Erkrankungen [DZNE]
Lohner, Valerie [Auteur]
Ware, James S. [Auteur]
Imperial College London
Debette, Stephanie [Auteur]
Bordeaux population health [BPH]
Elliott, Paul [Auteur]
Imperial College London
Dehghan, Abbas [Auteur]
Imperial College London
Matthews, Paul M. [Auteur]
Imperial College London
Imperial College London
Futschik, Matthias E. [Auteur]
Imperial College London
Huang, Jian [Auteur]
Imperial College London
Bai, Wenjia [Auteur]
Imperial College London
Sargurupremraj, Muralidharan [Auteur]
Bordeaux population health [BPH]
Teumer, Alexander [Auteur]
German Center for Cardiovascular Research [DZHK]
University of Medicine Greifswald
Breteler, Monique M. B. [Auteur]
German Research Center for Neurodegenerative Diseases - Deutsches Zentrum für Neurodegenerative Erkrankungen [DZNE]
Petretto, Enrico [Auteur]
National University of Singapore [NUS]
Ho, Amanda S. R. [Auteur]
National University of Singapore [NUS]
Amouyel, Philippe [Auteur]
Facteurs de Risque et Déterminants Moléculaires des Maladies liées au Vieillissement - U 1167 [RID-AGE]
Engelter, Stefan T. [Auteur]
Bulow, Robin [Auteur]
University of Medicine Greifswald
Volker, Uwe [Auteur]
University of Medicine Greifswald
Volzke, Henry [Auteur]
University of Medicine Greifswald
Dorr, Marcus [Auteur]
German Center for Cardiovascular Research [DZHK]
Imtiaz, Mohammed-Aslam [Auteur]
German Research Center for Neurodegenerative Diseases - Deutsches Zentrum für Neurodegenerative Erkrankungen [DZNE]
Aziz, N. Ahmad [Auteur]
German Research Center for Neurodegenerative Diseases - Deutsches Zentrum für Neurodegenerative Erkrankungen [DZNE]
Lohner, Valerie [Auteur]
Ware, James S. [Auteur]
Imperial College London
Debette, Stephanie [Auteur]
Bordeaux population health [BPH]
Elliott, Paul [Auteur]
Imperial College London
Dehghan, Abbas [Auteur]
Imperial College London
Matthews, Paul M. [Auteur]
Imperial College London
Titre de la revue :
Nature Communications
Pagination :
4505
Éditeur :
Nature Publishing Group
Date de publication :
2022-08-03
ISSN :
2041-1723
Discipline(s) HAL :
Sciences du Vivant [q-bio]/Médecine humaine et pathologie/Cardiologie et système cardiovasculaire
Sciences du Vivant [q-bio]/Neurosciences [q-bio.NC]
Sciences du Vivant [q-bio]/Génétique/Génétique humaine
Sciences du Vivant [q-bio]/Neurosciences [q-bio.NC]
Sciences du Vivant [q-bio]/Génétique/Génétique humaine
Résumé en anglais : [en]
Aortic dimensions and distensibility are key risk factors for aortic aneurysms and dissections, as well as for other cardiovascular and cerebrovascular diseases. We present genome-wide associations of ascending and descending ...
Lire la suite >Aortic dimensions and distensibility are key risk factors for aortic aneurysms and dissections, as well as for other cardiovascular and cerebrovascular diseases. We present genome-wide associations of ascending and descending aortic distensibility and area derived from cardiac magnetic resonance imaging (MRI) data of up to 32,590 Caucasian individuals in UK Biobank. We identify 102 loci (including 27 novel associations) tagging genes related to cardiovascular development, extracellular matrix production, smooth muscle cell contraction and heritable aortic diseases. Functional analyses highlight four signalling pathways associated with aortic distensibility (TGF-beta, IGF, VEGF and PDGF). We identify distinct sex-specific associations with aortic traits. We develop co-expression networks associated with aortic traits and apply phenome-wide Mendelian randomization (MR-PheWAS), generating evidence for a causal role for aortic distensibility in development of aortic aneurysms. Multivariable MR suggests a causal relationship between aortic distensibility and cerebral white matter hyperintensities, mechanistically linking aortic traits and brain small vessel disease.Lire moins >
Lire la suite >Aortic dimensions and distensibility are key risk factors for aortic aneurysms and dissections, as well as for other cardiovascular and cerebrovascular diseases. We present genome-wide associations of ascending and descending aortic distensibility and area derived from cardiac magnetic resonance imaging (MRI) data of up to 32,590 Caucasian individuals in UK Biobank. We identify 102 loci (including 27 novel associations) tagging genes related to cardiovascular development, extracellular matrix production, smooth muscle cell contraction and heritable aortic diseases. Functional analyses highlight four signalling pathways associated with aortic distensibility (TGF-beta, IGF, VEGF and PDGF). We identify distinct sex-specific associations with aortic traits. We develop co-expression networks associated with aortic traits and apply phenome-wide Mendelian randomization (MR-PheWAS), generating evidence for a causal role for aortic distensibility in development of aortic aneurysms. Multivariable MR suggests a causal relationship between aortic distensibility and cerebral white matter hyperintensities, mechanistically linking aortic traits and brain small vessel disease.Lire moins >
Langue :
Anglais
Vulgarisation :
Non
Projet ANR :
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