Title :

Does Estimated Pulse Wave Velocity Add Prognostic Information?

Author(s) :

Vishram-Nielsen, Julie K.K. [Auteur]
Bispebjerg University Hospital [BUH]
Rigshospitalet [Copenhagen]
Laurent, Stephane [Auteur]
Paris-Centre de Recherche Cardiovasculaire [PARCC (UMR_S 970/ U970)]
Nilsson, Peter [Auteur]
Skane University Hospital [Malmo]
Linneberg, Allan [Auteur]
Bispebjerg University Hospital [BUH]
University of Copenhagen = Københavns Universitet [UCPH]
Sehested, Thomas S.G. [Auteur]
Bispebjerg University Hospital [BUH]
Greve, Sara [Auteur]
Odense University Hospital [OUH]
Pareek, Manan [Auteur]
Nordsjællands Hospital
Yale University [New Haven]
Yale New Haven Hospital
Palmieri, Luigi [Auteur]
National Centre for Epidemiology, Surveillance and Health Promotion = Centro nazionale di epidemiologia, sorveglianza e promozione della salute [CNESPS]
Giampaoli, Simona [Auteur]
National Centre for Epidemiology, Surveillance and Health Promotion = Centro nazionale di epidemiologia, sorveglianza e promozione della salute [CNESPS]
Donfrancesco, Chiara [Auteur]
National Centre for Epidemiology, Surveillance and Health Promotion = Centro nazionale di epidemiologia, sorveglianza e promozione della salute [CNESPS]
Kee, Frank [Auteur]
Queen's University [Belfast] [QUB]
Mancia, Giuseppe [Auteur]
Università degli Studi di Milano-Bicocca = University of Milano-Bicocca [UNIMIB]
Cesana, Giancarlo [Auteur]
Università degli Studi di Milano-Bicocca = University of Milano-Bicocca [UNIMIB]
Veronesi, Giovanni [Auteur]
Universitá degli Studi dell’Insubria = University of Insubria [Varese] [Uninsubria]
Kuulasmaa, Kari [Auteur]
Finnish Institute for Health and Welfare [FIHW]
Salomaa, Veikko [Auteur]
Finnish Institute for Health and Welfare [FIHW]
Kontto, Jukka [Auteur]
Finnish Institute for Health and Welfare [FIHW]
Palosaari, Tarja [Auteur]
Finnish Institute for Health and Welfare [FIHW]
Sans, Susana [Auteur]
Ferrieres, Jean [Auteur]
Service Cardiologie [CHU Toulouse]
Dallongeville, Jean [Auteur]
Institut Pasteur de Lille
Facteurs de Risque et Déterminants Moléculaires des Maladies liées au Vieillissement - U 1167 [RID-AGE]
Söderberg, Stefan [Auteur]
Umeå University = Umeå Universitet
Moitry, Marie [Auteur]
Université de Strasbourg [UNISTRA]
Centre Hospitalier Universitaire [Strasbourg] [CHU Strasbourg]
Drygas, Wojciech [Auteur]
National Institute of Cardiology [Warsaw, Poland] [NIC]
Tamosiunas, Abdonas [Auteur]
Lithuanian University of health Sciences [LSMU]
Peters, Annette [Auteur]
Helmholtz Zentrum München = German Research Center for Environmental Health [HMGU]
Brenner, Hermann [Auteur]
Universität Heidelberg [Heidelberg] = Heidelberg University
Njolstad, Inger [Auteur]
University of Tromsø [UiT]
Olsen, Michael [Auteur]
Holbæk Hospital
University of Southern Denmark [SDU]

Journal title :

Hypertension

Pages :

1420-1428

Publisher :

American Heart Association

Publication date :

2020-06

ISSN :

0194-911X

English keyword(s) :

cardiovascular risk
prognosis
pulse wave velocity
reclassification

HAL domain(s) :

Sciences du Vivant [q-bio]
Sciences du Vivant [q-bio]/Santé publique et épidémiologie

English abstract : [en]

The Reference Values for Arterial Stiffness Collaboration has derived an equation using age and mean blood pressure to estimated pulse wave velocity (ePWV), which predicted cardiovascular events independently of Systematic ...
Show more >The Reference Values for Arterial Stiffness Collaboration has derived an equation using age and mean blood pressure to estimated pulse wave velocity (ePWV), which predicted cardiovascular events independently of Systematic COoronary Risk Evaluation (SCORE) and Framingham Risk Score. The study aim was to investigate the independent association between ePWV and clinical outcomes in 107 599 apparently healthy subjects (53% men) aged 19 to 97 years from the MORGAM Project who were included between 1982 and 2002 in 38 cohorts from 11 countries. Using multiple Cox-regression analyses, the predictive value of ePWV was calculated adjusting for country of inclusion and either SCORE, Framingham Risk Score, or traditional cardiovascular risk factors (age, sex, smoking, systolic blood pressure, body mass index [BMI], total and high-density lipoprotein cholesterol). Cardiovascular mortality consisted of fatal stroke, fatal myocardial infarction, or coronary death, and the composite cardiovascular end point consisted of stroke, myocardial infarction, or coronary death. Model discrimination was assessed using Harrell’s C -statistic. Adjusting for country and logSCORE or Framingham Risk Score, ePWV was associated with all-cause mortality (hazard ratio, 1.23 [95% CI 1.20–1.25] per m/s or 1.32 [1.29–1.34]), cardiovascular mortality (1.26 [1.21–1.32] or 1.35 [1.31–1.40]), and composite cardiovascular end point (1.19 [1.16–1.22] or 1.23 [1.20–1.25]; all P <0.001). However, after adjusting for traditional cardiovascular risk factors, ePWV was only associated with all-cause mortality (1.15 [1.08–1.22], P <0.001) and not with cardiovascular mortality (0.97 [0.91–1.03]) nor composite cardiovascular end point (1.10 [0.97–1.26]). The areas under the last 3 receiver operator characteristic curves remained unchanged when adding ePWV. Elevated ePWV was associated with subsequent mortality and cardiovascular morbidity independently of systematic coronary risk evaluation and Framingham Risk Score but not independently of traditional cardiovascular risk factors.Show less >

Language :

Anglais

Peer reviewed article :

Oui

Audience :

Internationale

Popular science :

Non

Collections :

• Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement (RID-AGE) - U1167

Source :

Harvested from HAL