Titre :

Predictive Importance of Blood Pressure Characteristics With Increasing Age in Healthy Men and Women

Auteur(s) :

Vishram-Nielsen, Julie K.K. [Auteur]
University of Copenhagen = Københavns Universitet [UCPH]
Bispebjerg University Hospital [BUH]
Kristensen, Anna [Auteur]
Nordsjællands Hospital [Hillerød, Denmark]
Pareek, Manan [Auteur]
Yale University [New Haven]
Nordsjællands Hospital [Hillerød, Denmark]
Laurent, Stephane [Auteur]
Hôpital Européen Georges Pompidou [APHP] [HEGP]
Paris-Centre de Recherche Cardiovasculaire [PARCC (UMR_S 970/ U970)]
Nilsson, Peter [Auteur]
Skane University Hospital [Malmo]
Linneberg, Allan [Auteur]
University of Copenhagen = Københavns Universitet [UCPH]
Bispebjerg University Hospital [BUH]
Greve, Sara [Auteur]
Odense University Hospital [OUH]
Palmieri, Luigi [Auteur]
Istituto Superiore di Sanità = National Institute of Health [ISS]
Giampaoli, Simona [Auteur]
Istituto Superiore di Sanità = National Institute of Health [ISS]
Donfrancesco, Chiara [Auteur]
Istituto Superiore di Sanità = National Institute of Health [ISS]
Kee, Frank [Auteur]
Queen's University [Belfast] [QUB]
Mancia, Giuseppe [Auteur]
Università degli Studi di Milano-Bicocca = University of Milano-Bicocca [UNIMIB]
Cesana, Giancarlo [Auteur]
Università degli Studi di Milano-Bicocca = University of Milano-Bicocca [UNIMIB]
Veronesi, Giovanni [Auteur]
Universitá degli Studi dell’Insubria = University of Insubria [Varese] [Uninsubria]
Grassi, Guido [Auteur]
Università degli Studi di Milano-Bicocca = University of Milano-Bicocca [UNIMIB]
Kuulasmaa, Kari [Auteur]
Finnish Institute for Health and Welfare [FIHW]
Salomaa, Veikko [Auteur]
Finnish Institute for Health and Welfare [FIHW]
Palosaari, Tarja [Auteur]
Finnish Institute for Health and Welfare [FIHW]
Sans, Susana [Auteur]
Ferrieres, Jean [Auteur]
Service Cardiologie [CHU Toulouse]
Dallongeville, Jean [Auteur]
Facteurs de Risque et Déterminants Moléculaires des Maladies liées au Vieillissement - U 1167 [RID-AGE]
Institut Pasteur de Lille
Söderberg, Stefan [Auteur]
Umeå University = Umeå Universitet
Moitry, Marie [Auteur]
Centre Hospitalier Universitaire [Strasbourg] [CHU Strasbourg]
Université de Strasbourg [UNISTRA]
Drygas, Wojciech [Auteur]
National Institute of Cardiology [Warsaw, Poland] [NIC]
Tamosiunas, Abdonas [Auteur]
Lithuanian University of health Sciences [LSMU]
Peters, Annette [Auteur]
Helmholtz Zentrum München = German Research Center for Environmental Health [HMGU]
Brenner, Hermann [Auteur]
Universität Heidelberg [Heidelberg] = Heidelberg University
German Cancer Research Center - Deutsches Krebsforschungszentrum [Heidelberg] [DKFZ]
Grimsgaard, Sameline [Auteur]
The Arctic University of Norway [Tromsø, Norway] [UiT]
Savallampi, Matti [Auteur]
Finnish Institute for Health and Welfare [FIHW]
Olsen, Michael [Auteur]
University of Southern Denmark [SDU]
Holbæk Hospital

Titre de la revue :

Hypertension

Pagination :

1076-1085

Éditeur :

American Heart Association

Date de publication :

2021-04

ISSN :

0194-911X

Mot(s)-clé(s) en anglais :

blood pressure
cardiovascular disease
myocardial infarction
prognosis
risk factor

Discipline(s) HAL :

Sciences du Vivant [q-bio]

Résumé en anglais : [en]

It remains unclear which blood pressure (BP) characteristics best predict cardiovascular risk in different age groups and between sexes. We leveraged data from the MORGAM (MONICA [Monitoring of Trends and Determinants in ...
Lire la suite >It remains unclear which blood pressure (BP) characteristics best predict cardiovascular risk in different age groups and between sexes. We leveraged data from the MORGAM (MONICA [Monitoring of Trends and Determinants in Cardiovascular Disease], Risk, Genetics, Archiving and Monograph) Project to investigate determinants of BP characteristics and their prognostic importance, in younger and older (</≥50 years) men and women. The study population comprised 107 599 individuals (53% men) aged 19 to 97 years without established cardiovascular disease, not on antihypertensive treatment, recruited between 1982 and 2008 in 38 cohorts. Covariates of BP characteristics were explored using multivariable linear regression. Prognostic importance was examined using multivariable Cox proportional-hazards regression, area under the receiver operating characteristic curve, and net reclassification improvement. The primary end point was a composite cardiovascular end point (CEP), defined as fatal or nonfatal stroke, death from coronary heart disease or nonfatal myocardial infarction. The positive association between age and systolic BP was more pronounced among individuals ≥50 years while the same was true for diastolic BP in those <50 years ( P interaction <0.001). Higher systolic BP and mean BP were significantly associated with cardiovascular end point, irrespective of age group ( P <0.001), but diastolic BP only demonstrated an independent relationship in the younger group ( P <0.001). Brachial pulse pressure was associated with cardiovascular end point in the older age group ( P <0.001). In subjects <50 years, diastolic BP significantly improved area under the receiver operating characteristic curve compared with Systematic Coronary Risk Evaluation variables (including systolic BP) alone (0.842 versus 0.840, P =0.03), enhanced continuous net reclassification improvement (0.150 [95% CI, 0.087–0.215]) and improved the prognostic value of the European Society of Cardiology/European Society of Hypertension hypertension definition (categorical net reclassification improvement=0.0255, P =0.005). In conclusion, diastolic BP may provide additional prognostic utility beyond systolic BP, in predicting composite cardiovascular events among younger individuals.Lire moins >

Langue :

Anglais

Comité de lecture :

Oui

Audience :

Internationale

Vulgarisation :

Non

Collections :

• Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement (RID-AGE) - U1167

Source :

Harvested from HAL