Interleukin-7, a new cytokine targeting ...
Document type :
Article dans une revue scientifique: Article original
PMID :
Permalink :
Title :
Interleukin-7, a new cytokine targeting the mouse hypothalamic arcuate nucleus: role in body weight and food intake regulation
Author(s) :
Macia, Laurence [Auteur]
Viltart, Odile [Auteur]
Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer - U1172 Inserm - U837 [JPArc]
Delacre, Myriam [Auteur]
Institut Pasteur de Lille
Sachot, Christelle [Auteur]
Héliot, Laurent [Auteur]
Di Santo, James P [Auteur]
Institut Pasteur [Paris] [IP]
Wolowczuk, Isabelle [Auteur]
Institut Pasteur de Lille
Viltart, Odile [Auteur]
Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer - U1172 Inserm - U837 [JPArc]
Delacre, Myriam [Auteur]
Institut Pasteur de Lille
Sachot, Christelle [Auteur]
Héliot, Laurent [Auteur]
Di Santo, James P [Auteur]
Institut Pasteur [Paris] [IP]
Wolowczuk, Isabelle [Auteur]
Institut Pasteur de Lille
Journal title :
PLoS ONE
Abbreviated title :
PLoS One
Volume number :
5
Pages :
e9953
Publication date :
2010-04-01
ISSN :
1932-6203
English keyword(s) :
Animals
Appetite Regulation
Body Weight
Brain Chemistry
Hypothalamus
Interleukin-7
Mice
Neurons
Obesity
Phosphorylation
Receptors, Interleukin-7
STAT3 Transcription Factor
Appetite Regulation
Body Weight
Brain Chemistry
Hypothalamus
Interleukin-7
Mice
Neurons
Obesity
Phosphorylation
Receptors, Interleukin-7
STAT3 Transcription Factor
HAL domain(s) :
Sciences cognitives
English abstract : [en]
Body weight is controlled through peripheral (white adipose tissue) and central (mainly hypothalamus) mechanisms. We have recently obtained evidence that overexpression of interleukin (IL)-7, a critical cytokine involved ...
Show more >Body weight is controlled through peripheral (white adipose tissue) and central (mainly hypothalamus) mechanisms. We have recently obtained evidence that overexpression of interleukin (IL)-7, a critical cytokine involved in lymphopoiesis, can protect against the development of diet-induced obesity in mice. Here we assessed whether IL-7 mediated its effects by modulating hypothalamic function. Acute subcutaneous injection of IL-7 prevented monosodium glutamate-induced obesity, this being correlated with partial protection against cell death in the hypothalamic arcuate nucleus (ARC). Moreover, we showed that IL-7 activated hypothalamic areas involved in regulation of feeding behavior, as indicated by induction of the activation marker c-Fos in neural cells located in the ventromedial part of the ARC and by inhibition of food intake after fasting. Both chains of the IL-7 receptor (IL-7Ralpha and gamma(c)) were expressed in the ARC and IL-7 injection induced STAT-3 phosphorylation in this area. Finally, we established that IL-7 modulated the expression of neuropeptides that tune food intake, with a stimulatory effect on the expression of pro-opiomelanocortin and an inhibitory effect on agouti-related peptide expression in accordance with IL-7 promoting anorectic effects. These results suggest that the immunomodulatory cytokine IL-7 plays an important and unappreciated role in hypothalamic body weight regulation.Show less >
Show more >Body weight is controlled through peripheral (white adipose tissue) and central (mainly hypothalamus) mechanisms. We have recently obtained evidence that overexpression of interleukin (IL)-7, a critical cytokine involved in lymphopoiesis, can protect against the development of diet-induced obesity in mice. Here we assessed whether IL-7 mediated its effects by modulating hypothalamic function. Acute subcutaneous injection of IL-7 prevented monosodium glutamate-induced obesity, this being correlated with partial protection against cell death in the hypothalamic arcuate nucleus (ARC). Moreover, we showed that IL-7 activated hypothalamic areas involved in regulation of feeding behavior, as indicated by induction of the activation marker c-Fos in neural cells located in the ventromedial part of the ARC and by inhibition of food intake after fasting. Both chains of the IL-7 receptor (IL-7Ralpha and gamma(c)) were expressed in the ARC and IL-7 injection induced STAT-3 phosphorylation in this area. Finally, we established that IL-7 modulated the expression of neuropeptides that tune food intake, with a stimulatory effect on the expression of pro-opiomelanocortin and an inhibitory effect on agouti-related peptide expression in accordance with IL-7 promoting anorectic effects. These results suggest that the immunomodulatory cytokine IL-7 plays an important and unappreciated role in hypothalamic body weight regulation.Show less >
Language :
Anglais
Peer reviewed article :
Oui
Audience :
Internationale
Popular science :
Non
Administrative institution(s) :
Université de Lille
CNRS
CHU Lille
CNRS
CHU Lille
Collections :
Submission date :
2024-01-12T14:45:14Z
2024-02-28T12:38:35Z
2024-02-28T12:38:35Z
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