Titre :

Time to steroids impacts visual outcome of optic neuritis in MOGAD

Auteur(s) :

Rode, Julie [Auteur]
Neurologie, maladies neuro-musculaires [Hôpital de la Timone - APHM]
Pique, J. [Auteur]
Maarouf, A. [Auteur]
Ayrignac, X. [Auteur]
Bourre, B. [Auteur]
Ciron, J. [Auteur]
Cohen, M. [Auteur]
Collongues, N. [Auteur]
Deschamps, R. [Auteur]
Maillart, E. [Auteur]
Montcuquet, A. [Auteur]
Papeix, C. [Auteur]
Ruet, A. [Auteur]
Wiertlewski, S. [Auteur]
Zephir, Helene [Auteur]
Lille Neurosciences & Cognition (LilNCog) - U 1172
Marignier, R. [Auteur]
Audoin, B. [Auteur]

Titre de la revue :

Journal of Neurology, Neurosurgery and Psychiatry

Numéro :

94

Pagination :

309-313

Éditeur :

BMJ Journals

Date de publication :

2023-02-28

ISSN :

0022-3050

Mot(s)-clé(s) :

NEUROOPHTHALMOLOGY
NEUROIMMUNOLOGY
VISION
CLINICAL NEUROLOGY

Discipline(s) HAL :

Sciences du Vivant [q-bio]

Résumé en anglais : [en]

Background To characterise the response to treatment of inaugural optic neuritis (ON) in patients with myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD). Methods We searched the French MOGAD database ...
Lire la suite >Background To characterise the response to treatment of inaugural optic neuritis (ON) in patients with myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD). Methods We searched the French MOGAD database for adults with inaugural ON with a detailed report of acute treatment modalities and measures of high-contrast best-corrected visual acuity (BCVA) at nadir and after 3 months. Predictors of visual outcomes were assessed by multivariable analysis. Results Among 245 patients with at least one episode of ON, 82 fulfilled all criteria, and data on the peripapillary retinal nerve fibre layer (pRNFL) were available for 44. All patients received methylprednisolone (MP), combined with plasma exchange in 18. After 3 months, 75 of 82 (91%) patients retained full BCVA recovery, and median (range) pRNFL of the affected eye was 72 µm (40–102). Failure to regain 0.0 logarithmic minimum angle of resolution vision (Snellen 20/20) at 3 months was associated with time to first MP treatment ≥10 days (OR 16, 95% CI 1.14 to 213, p=0.01). pRNFL thickness after 3 months was related to better BCVA at nadir and time to first MP treatment <10 days (r2=19%, p=0.004 and r2=11%, p=0.03, respectively). Conclusions Time to MP affects functional but also structural visual outcomes of ON in MOGAD.Lire moins >

Langue :

Anglais

Audience :

Internationale

Vulgarisation :

Non

Établissement(s) :

Université de Lille
Inserm
CHU Lille

Collections :

• Lille Neurosciences & Cognition (LilNCog) - U 1172

Date de dépôt :

2024-01-15T23:56:12Z
2024-07-03T07:59:05Z