Title :

Surveillance of HIV-1 primary infections in France from 2014 to 2016: toward stable resistance, but higher diversity, clustering and virulence?

Author(s) :

Visseaux, Benoit [Auteur]
Infection, Anti-microbiens, Modélisation, Evolution [IAME (UMR_S_1137 / U1137)]
Assoumou, Lambert [Auteur]
Institut Pierre Louis d'Epidémiologie et de Santé Publique [iPLESP]
Mahjoub, Nadia [Auteur]
Laboratoire de Virologie [CHU Saint-Louis]
Grude, Maxime [Auteur]
Institut Pierre Louis d'Epidémiologie et de Santé Publique [iPLESP]
Trabaud, Mary-Anne [Auteur]
Hôpital de la Croix-Rousse [CHU - HCL]
Raymond, Stéphanie [Auteur]
Laboratoire Virologie [CHU Toulouse]
Wirden, Marc [Auteur]
CHU Pitié-Salpêtrière [AP-HP]
Morand-Joubert, Laurence [Auteur]
Institut Pierre Louis d'Epidémiologie et de Santé Publique [iPLESP]
Roussel, Catherine [Auteur]
Laboratoire de Virologie [CHU Amiens]
Montes, Brigitte [Auteur]
Laboratoire de Virologie [CHRU Montpellier]
Bocket, Laurence [Auteur]
Laboratoire de virologie - ULR 3610
Fafi-Kremer, Samira [Auteur]
Laboratoire de Virologie [Strasbourg]
Amiel, Corinne [Auteur]
CHU Tenon [AP-HP]
De Monte, Anne [Auteur]
CHU Nice [Cimiez]
Stefic, Karl [Auteur]
Morphogénèse et antigénicité du VIH, des Virus des Hépatites et Emergents [MAVIVHe]
Pallier, Coralie [Auteur]
Hôpital Paul Brousse
Tumiotto, Camille [Auteur]
Service de virologie et unité de surveillance biologique [Bordeaux]
Maillard, Anne [Auteur]
Laboratoire de Virologie [Rennes] = Virology [Rennes]
Vallet, Sophie [Auteur]
Université de Brest [UBO]
Ferre, Virginie [Auteur]
Service de virologie [CHU Nantes]
Bouvier-Alias, Magali [Auteur]
Service de bactériologie, virologie, hygiène [Mondor]
Dina, Julia [Auteur]
CHU Caen
Signori-Schmuck, Anne [Auteur]
Département de virologie [Grenoble]
Carles, Marie-Josée [Auteur]
Centre Hospitalier Universitaire de Nîmes [CHU Nîmes]
Plantier, Jean-Christophe [Auteur]
Dynamique Microbienne associée aux Infections Urinaires et Respiratoires [DYNAMICURE]
Meyer, Laurence [Auteur]
Centre de recherche en épidémiologie et santé des populations [CESP]
Descamps, Diane [Auteur]
Infection, Anti-microbiens, Modélisation, Evolution [IAME (UMR_S_1137 / U1137)]
Chaix, Marie-Laure [Auteur]
Génomes, biologie cellulaire et thérapeutiques [GenCellDis (U944 / UMR7212)]

Journal title :

Journal of Antimicrobial Chemotherapy

Abbreviated title :

J. Antimicrob. Chemother.

Volume number :

75

Pages :

183–193

Publication date :

2019-10-26

ISSN :

1460-2091

HAL domain(s) :

Sciences du Vivant [q-bio]/Microbiologie et Parasitologie/Virologie

English abstract : [en]

Objectives Patients with primary HIV-1 infection (PHI) are a particular population, giving important insight about ongoing evolution of transmitted drug resistance-associated mutation (TDRAM) prevalence, HIV diversity ...
Show more >Objectives Patients with primary HIV-1 infection (PHI) are a particular population, giving important insight about ongoing evolution of transmitted drug resistance-associated mutation (TDRAM) prevalence, HIV diversity and clustering patterns. We describe these evolutions of PHI patients diagnosed in France from 2014 to 2016. Methods A total of 1121 PHI patients were included. TDRAMs were characterized using the 2009 Stanford list and the French ANRS algorithm. Viral subtypes and recent transmission clusters (RTCs) were also determined. Results Patients were mainly MSM (70%) living in the Paris area (42%). TDRAMs were identified among 10.8% of patients and rose to 18.6% when including etravirine and rilpivirine TDRAMs. Prevalences of PI-, NRTI-, first-generation NNRTI-, second-generation NNRTI- and integrase inhibitor-associated TDRAMs were 2.9%, 5.0%, 4.0%, 9.4% and 5.4%, respectively. In a multivariable analysis, age >40 years and non-R5 tropic viruses were associated with a >2-fold increased risk of TDRAMs. Regarding HIV diversity, subtype B and CRF02_AG (where CRF stands for circulating recombinant form) were the two main lineages (56% and 20%, respectively). CRF02_AG was associated with higher viral load than subtype B (5.83 versus 5.40 log10 copies/mL, P=0.004). We identified 138 RTCs ranging from 2 to 14 patients and including overall 41% from the global population. Patients in RTCs were younger, more frequently born in France and more frequently MSM. Conclusions Since 2007, the proportion of TDRAMs has been stable among French PHI patients. Non-B lineages are increasing and may be associated with more virulent CRF02_AG strains. The presence of large RTCs highlights the need for real-time cluster identification to trigger specific prevention action to achieve better control of the epidemic.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Université de Lille
CHU Lille

Collections :

• Laboratoire de virologie - ULR 3610

Submission date :

2024-01-17T22:26:48Z
2024-02-13T09:27:49Z