Title :

The Use of Image Guided Programming to Improve Deep Brain Stimulation Workflows with Directional Leads in Parkinson's Disease

Author(s) :

Rolland, Anne-Sophie [Auteur]
1049721|||Lille Neurosciences & Cognition - U 1172 [LilNCog] (VALID)
Département de Pharmacologie Médicale [Lille] [Pôle Recherche]
Touzet, Gustavo [Auteur]
Département de Neurochirurgie[Lille]
Carriere, Nicolas [Auteur]
42992|||Département de neurologie [Lille] (VALID)
Lille Neurosciences & Cognition - U 1172 [LilNCog]
Mutez, Eugenie [Auteur]
Lille Neurosciences & Cognition (LilNCog) - U 1172
Département de neurologie [Lille]
Kreisler, Alexandre [Auteur]
Lille Neurosciences & Cognition - U 1172 [LilNCog]
Département de neurologie [Lille]
Simonin, Clemence [Auteur]
Lille Neurosciences & Cognition (LilNCog) - U 1172
Département de neurologie [Lille]
Kuchcinski, Gregory [Auteur]
Lille Neurosciences & Cognition - U 1172 [LilNCog]
Departement de Neuroradiologie [Lille]
Chalhoub, Najib [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Pruvo, Jean-Pierre [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Defebvre, Luc [Auteur]
Lille Neurosciences & Cognition - U 1172 [LilNCog]
Département de neurologie [Lille]
Reyns, Nicolas [Auteur]
Département de Neurochirurgie[Lille]
Devos, David [Auteur]
Lille Neurosciences & Cognition - U 1172 [LilNCog]
Département de Pharmacologie Médicale [Lille] [Pôle Recherche]
Département de neurologie [Lille]
Moreau, caroline [Auteur]
Lille Neurosciences & Cognition - U 1172 [LilNCog]
Département de neurologie [Lille]

Journal title :

Journal of Parkinson's disease

Abbreviated title :

J Parkinsons Dis

Volume number :

14

Pages :

111-119

Publisher :

IOS Press Amsterdam, The Netherlands, The Netherlands

Publication date :

2023-12-30

ISSN :

1877-718X

English keyword(s) :

Directional leads
clinical programming
functional mapping
timesaving
clinical refinement
Parkinson’s disease

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Background: Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is a preferred treatment for parkinsonian patients with severe motor fluctuations. Proper targeting of the STN sensorimotor segment appears to be ...
Show more >Background: Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is a preferred treatment for parkinsonian patients with severe motor fluctuations. Proper targeting of the STN sensorimotor segment appears to be a crucial factor for success of the procedure. The recent introduction of directional leads theoretically increases stimulation specificity in this challenging area but also requires more precise stimulation parameters. Objective: We investigated whether commercially available software for image guided programming (IGP) could maximize the benefits of DBS by informing the clinical standard care (CSC) and improving programming workflows. Methods: We prospectively analyzed 32 consecutive parkinsonian patients implanted with bilateral directional leads in the STN. Double blind stimulation parameters determined by CSC and IGP were assessed and compared at three months post-surgery. IGP was used to adjust stimulation parameters if further clinical refinement was required. Overall clinical efficacy was evaluated one-year post-surgery. Results: We observed 78% concordance between the two electrode levels selected by the blinded IGP prediction and CSC assessments. In 64% of cases requiring refinement, IGP improved clinical efficacy or reduced mild side effects, predominantly by facilitating the use of directional stimulation (93% of refinements). Conclusions: The use of image guided programming saves time and assists clinical refinement, which may be beneficial to the clinical standard care for STN-DBS and further improve the outcomes of DBS for PD patients.Show less >

Language :

Anglais

Peer reviewed article :

Oui

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Université de Lille
Inserm
CHU Lille

Collections :

• Lille Neurosciences & Cognition (LilNCog) - U 1172

Research team(s) :

Troubles cognitifs dégénératifs et vasculaires
Brain Biology & Chemistry (BBC)

Submission date :

2024-01-18T22:04:28Z
2025-02-27T15:53:24Z