Gut-Joint Axis: Impact of Bifidobacterial Cell Wall Lipoproteins on Arthritis Development.

Piva, Frank; Gervois, Philippe; Karrout, Youness; Sane, Famara; Romond, Marie-Benedicte

Document type :

Article dans une revue scientifique: Article original

DOI :

10.3390/nu15234861

PMID :

38068720

Permalink :

http://hdl.handle.net/20.500.12210/103306

Title :

Gut-Joint Axis: Impact of Bifidobacterial Cell Wall Lipoproteins on Arthritis Development.

Author(s) :

Piva, Frank [Auteur]
Laboratoire de Virologie - ULR 3610 [Laboratoire de Virologie]
Gervois, Philippe [Auteur]
Laboratoire de virologie - ULR 3610
Karrout, Youness [Auteur]

Advanced Drug Delivery Systems (ADDS) - U1008
Sane, Famara [Auteur]

Laboratoire de virologie - ULR 3610
Romond, Marie-Benedicte [Auteur]

Laboratoire de virologie - ULR 3610

Journal title :

Nutrients

Abbreviated title :

Nutrients

Volume number :

Pages :

4861

Publication date :

2023-12-14

ISSN :

2072-6643

English keyword(s) :

lipoproteins
Bifidobacterium longum
rheumatoid arthritis
microbiome

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Gut microbiota affect progression of rheumatoid arthritis (RA). The present study aims at investigating the protective potential of Bifidobacterium longum cell wall lipoproteins (Lpps) shown to modulate the intestinal ...
Show more >Gut microbiota affect progression of rheumatoid arthritis (RA). The present study aims at investigating the protective potential of Bifidobacterium longum cell wall lipoproteins (Lpps) shown to modulate the intestinal microbiome and prevent osteoarthritis. Arthritis was induced by collagen (CIA) or anti-collagen antibodies (CAIA) injection. Intake of 0.5 mg of Lpps/L, but not 0.25 and 1 mg of Lpps/L, significantly alleviated RA symptoms in CIA DBA/1OOaHsd mice. The arthritis index (AI) was also reduced in CAIA mice. In the CIA-protected group, colon Ligilactobacillus murinus, caecal Lactobacillus johnsonii and spleen weight correlated with AI, whereas the reverse was observed with splenic CD11c+ dendritic cells (cDCs). The unprotected CIA Lpps group harbored higher cecal and colon E. coli and lower caecal L. murinus. Lpps administration to CAIA mice after arthritis induction led to lower colon E. plexicaudatum counts. Splenocytes from CIA-protected mice triggered by LPS secreted higher Il-10 than control ones. However, a higher IL-10 response was not elicited in gnotobiotic RA mice splenocytes with lower cDCs’ recruitment. Labeled bacteria with the Lpps signal were detected in CIA mice bone marrow (BM) cDCs 5 and 16 h post-gavage but not in Peyer’s patches and the spleen. In vitro uptake of Lpps by primary BM and thymus cells was observed within 24 h. An FACS analysis detected the Lpps signal in the plasmacytoid cell compartment but not in cDCs. In conclusion, Lpps dosing is critical for preventing arthritis progression and appropriately modulating the microbiome. Our results also highlight the possible triggering of the immune system by Lpps.Show less >

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Université de Lille
CHU Lille

Collections :

Submission date :

2024-01-19T22:04:22Z
2024-02-07T10:59:04Z

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Except where otherwise noted, this item's license is described as Attribution 3.0 United States

Version	Link	Modification date
2	20.500.12210/103306*	2024-02-07T10:57:04Z
1	20.500.12210/103306.1	2024-01-19T22:04:22Z

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