Title :

Free lipoproteins from Bifidobacterium longum alleviate osteoarthritis through modulation of the gut microbiome.

Author(s) :

Sane, Famara [Auteur]
Laboratoire de virologie - ULR 3610
Piva, Frank [Auteur]
Laboratoire de Virologie - ULR 3610 [Laboratoire de Virologie]
Romond, Marie-Benedicte [Auteur]
Laboratoire de virologie - ULR 3610

Journal title :

Microbiome Research Reports

Abbreviated title :

Microbiome Res Rep

Volume number :

2

Pages :

18

Publication date :

2023-12-05

ISSN :

2771-5965

English keyword(s) :

Lipoproteins
bifidobacteria
osteoarthritis
gut bacteria

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Aim: The “gut-joint” axis is suspected to be involved in the pathophysiology of osteoarthritis (OA). The present study aims at investigating the potential of lipoproteins (Lpps) secreted by Bifidobacterium longum to alleviate ...
Show more >Aim: The “gut-joint” axis is suspected to be involved in the pathophysiology of osteoarthritis (OA). The present study aims at investigating the potential of lipoproteins (Lpps) secreted by Bifidobacterium longum to alleviate OA progression in the rat. Methods: Experimental OA was induced in rats harbouring Schaedler Flora maintained in SPF conditions. Two weeks post-injection, 20 rats were randomized to water (n = 10) or 0.3 mg/L Lpps solution (n = 10). Weight and food intake were monitored for 6 weeks. At sacrifice, joints were scored using macroscopic and histological criteria. Serum LPS, Schaedler flora as well as selected intestinal bacteria were analyzed. Results: Lpps intake prevents OA progression. The protected rats showed a significant increase in lactobacilli along the intestine as well as in Mucispirillum schaedleri in the colon and a significant decrease in Parabacteroides goldsteini and Akkermansia in caecum and colon, respectively. There was no significant difference in serum lipopolysaccharide or bacteria translocating in Peyer's patches. Labelled Lpps were not detected in bone marrow of the OA joint. The principal component analysis points out that OA prevention is primarily associated with bacteria involved in the tryptophane degradation pathway and SCFA formation. Conclusion: In rats deprived of bifidobacteria, intake of B.longum Lpps prevented OA development and modulated the intestinal microbiome with a possible impact on the bacterial end-products. The link between Lpps and the gut microbial metabolome warrants further investigation.Show less >

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Université de Lille
CHU Lille

Collections :

• Laboratoire de virologie - ULR 3610

Submission date :

2024-01-19T22:04:39Z
2024-02-07T10:56:11Z