Title :

Insulin-producing organoids engineered from islet and amniotic epithelial cells to treat diabetes.

Author(s) :

Lebreton, Fanny [Auteur]
Lavallard, Vanessa [Auteur]
Bellofatto, Kevin [Auteur]
Bonnet, Romain [Auteur]
Wassmer, Charles H. [Auteur]
Perez, Lisa [Auteur]
Kalandadze, Vakhtang [Auteur]
Follenzi, Antonia [Auteur]
Boulvain, Michel [Auteur]
Pattou Kerr-Conte, Julie [Auteur]
Recherche translationnelle sur le diabète (RTD) - U1190
Goodman, David J. [Auteur]
Bosco, Domenico [Auteur]
Bernez, Thierry [Auteur]
Berishvili, Ekaterine [Auteur]

Journal title :

Nature Communications

Abbreviated title :

Nat Commun

Volume number :

10

Pages :

4491

Publication date :

2019-10-03

ISSN :

2041-1723

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Maintaining long-term euglycemia after intraportal islet transplantation is hampered by the considerable islet loss in the peri-transplant period attributed to inflammation, ischemia and poor angiogenesis. Here, we show ...
Show more >Maintaining long-term euglycemia after intraportal islet transplantation is hampered by the considerable islet loss in the peri-transplant period attributed to inflammation, ischemia and poor angiogenesis. Here, we show that viable and functional islet organoids can be successfully generated from dissociated islet cells (ICs) and human amniotic epithelial cells (hAECs). Incorporation of hAECs into islet organoids markedly enhances engraftment, viability and graft function in a mouse type 1 diabetes model. Our results demonstrate that the integration of hAECs into islet cell organoids has great potential in the development of cell-based therapies for type 1 diabetes. Engineering of functional mini-organs using this strategy will allow the exploration of more favorable implantation sites, and can be expanded to unlimited (stem-cell-derived or xenogeneic) sources of insulin-producing cells.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Université de Lille
Inserm
CHU Lille

Collections :

• Recherche translationnelle sur le diabète (RTD) - U1190

Submission date :

2024-01-19T23:42:13Z
2024-09-25T12:20:12Z