Title :

CATASTROPHIC ANTIPHOSPHOLIPID SYNDROME AND POSTERIOR OCULAR INVOLVEMENT

Author(s) :

Morel, Nathalie [Auteur]
Bonnet, Clémence [Auteur]
Mehawej, Hanane [Auteur]
Le Guern, Véronique [Auteur]
Pérard, Laurent [Auteur]
Roumier, Mathilde [Auteur]
Brezin, Antoine [Auteur]
Godeau, Bertrand [Auteur]
Haroche, Julien [Auteur]
Benhamou, Ygal [Auteur]
Lambert, Marc [Auteur]
Facteurs de Risque et Déterminants Moléculaires des Maladies liées au Vieillissement - U 1167 [RID-AGE]
Yelnik, Cécile [Auteur]
Facteurs de Risque et Déterminants Moléculaires des Maladies liées au Vieillissement - U 1167 [RID-AGE]
Maillard, Nicolas [Auteur]
Bodaghi, Bahram [Auteur]
Piette, Jean-Charles [Auteur]
Costedoat-Chalumeau, Nathalie [Auteur]

Journal title :

RETINA. The Journal of Retinal and Vitreous Diseases

Pages :

2332-2341

Publisher :

Lippincott, Williams & Wilkins

Publication date :

2021-11

ISSN :

0275-004X

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Purpose: To describe the posterior ophthalmic manifestations of catastrophic antiphospholipid syndrome. Methods: Retrospective case series of patients presenting with catastrophic antiphospholipid syndrome and posterior ...
Show more >Purpose: To describe the posterior ophthalmic manifestations of catastrophic antiphospholipid syndrome. Methods: Retrospective case series of patients presenting with catastrophic antiphospholipid syndrome and posterior segment ocular manifestations. The main outcomes were the type of posterior segment manifestations at catastrophic antiphospholipid syndrome diagnosis, specifically retinal vascular occlusion, vasculitis, or choroidopathy, and the final best-corrected visual acuity. Results: This study included 23 patients (11 cases treated by the authors and 12 published case reports); 21 (91%) of them female. Their median age at diagnosis was 28 years (range, 16–79 years). Ophthalmologic manifestations were usually bilateral (n = 19, 83%) and involved vascular occlusive retinopathy (n = 17, 74%), choroidopathy (n = 11, 48%), or retinal vasculitis (n = 1, 4%). Final best-corrected visual acuity was not significantly worse than the best-corrected visual acuity at diagnosis ( P = 0.16). Retinal vascular occlusions were associated with poorer final visual acuity than choroidopathy ( P = 0.002). After a median follow-up of 14 months (range, 2–132 months), nearly half the patients (n = 11, 48%) had permanent vision loss including best-corrected visual acuity of <20/400 for 4 patients. Conclusion: Posterior ophthalmic manifestations of catastrophic antiphospholipid syndrome were mainly bilateral retinal vascular occlusion, which had the worst visual prognosis, followed by choroidopathy and retinal vasculitis. Permanent visual loss was common.Show less >

Language :

Anglais

Popular science :

Non

Collections :

• Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement (RID-AGE) - U1167

Source :

Harvested from HAL