Elabela and apelin actions in healthy and pathological pregnancies

Eberle, Delphine; Marousez, Lucie; Hanssens, Sandy; Knauf, Claude; Breton, Christophe; Deruelle, Philippe; Lesage, Jean

Document type :

Article dans une revue scientifique: Article original

DOI :

10.1016/j.cytogfr.2019.03.003

PMID :

30910349

Permalink :

http://hdl.handle.net/20.500.12210/104917

Title :

Elabela and apelin actions in healthy and pathological pregnancies

Author(s) :

Eberle, Delphine [Auteur]

Environnement Périnatal et Santé - EA 4489
Marousez, Lucie [Auteur]

Environnement Périnatal et Santé - EA 4489
Hanssens, Sandy [Auteur]
Environnement périnatal et croissance - EA 4489 [EPS]
Knauf, Claude [Auteur]
Institut de Recherche en Santé Digestive [IRSD ]
Breton, Christophe [Auteur]

Environnement Périnatal et Santé - EA 4489
Deruelle, Philippe [Auteur]
Environnement périnatal et croissance - EA 4489 [EPS]
Lesage, Jean [Auteur]
Environnement périnatal et croissance - EA 4489 [EPS]

Journal title :

Cytokine & Growth Factor Reviews

Abbreviated title :

Cytokine Growth Factor Rev.

Volume number :

Pages :

45-53

Publication date :

2019-04

ISSN :

1879-0305

English keyword(s) :

Elabela
Apelin
Fetus
Placenta
Gestational diabetes
Preeclampsia

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Pregnancy is a dynamic and precisely organized process during which one or more baby develops. Embryonic development relies on the formation of the placenta, allowing nutrient and oxygen exchange between the mother and the ...
Show more >Pregnancy is a dynamic and precisely organized process during which one or more baby develops. Embryonic development relies on the formation of the placenta, allowing nutrient and oxygen exchange between the mother and the fetus. Dysfunction of placental formation lead to pregnancy disorders such as preeclampsia (PE) with serious deleterious consequences for fetal and maternal health. Identifying factors involved in fetoplacental homeostasis could inform better diagnostic and therapeutic strategies for these pathological pregnancies. Here, we summarize actions of elabela, apelin and their common receptor APJ in the fetoplacental unit. Studies indicate that elabela is crucial for embryo cardiovascular system formation and early placental development, while apelin acts in mid/late gestation to modulate fetal angiogenesis and energy homeostasis. Most of these findings, drawn from animal models, indicate a key role of elabela/apelin-APJ system in the fetoplacental unit. This review also provides an overview of clinical studies investigating elabela/apelin-APJ system in pathological complicated pregnancies such as PE and gestational diabetes mellitus (GDM). While elabela-deficient mice display all the features of PE, current clinical studies show no difference in circulating elabela levels between PE and control patients which does not support a role in PE development. Conversely, apelin levels are increased during PE, but the use of apelin as an early PE marker remains to be fully investigated.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

CHU Lille
CNRS
Inserm
Institut Pasteur de Lille
Université de Lille

Collections :

Environnement Périnatal et Santé - ULR 4489

Submission date :

2024-01-30T10:27:33Z
2024-05-07T12:33:00Z

Version	Link	Modification date
2	20.500.12210/104917*	2024-05-07T12:29:32Z
1	20.500.12210/104917.1	2024-01-30T10:27:33Z

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