Title :

Volumetric changes and clinical trajectories in Parkinson's disease: a prospective multicentric study.

Author(s) :

Marques, Ana [Auteur]
Institut Pascal [IP]
Macias, Elise [Auteur]
Institut Pascal [IP]
Pereira, Bruno [Auteur]
Direction de la Recherche Clinique et de l’Innovation [CHU Clermont-Ferrand] [DRCI]
Durand, Elodie [Auteur]
Institut Pascal [IP]
Chassain, Carine [Auteur]
Institut Pascal [IP]
Vidal, Tiphaine [Auteur]
Institut Pascal [IP]
Defebvre, Luc [Auteur]
Lille Neurosciences & Cognition (LilNCog) - U 1172
Carriere, Nicolas [Auteur]
Lille Neurosciences & Cognition - U 1172 [LilNCog]
Fraix, Valerie [Auteur]
[GIN] Grenoble Institut des Neurosciences [GIN]
Moro, Elena [Auteur]
[GIN] Grenoble Institut des Neurosciences [GIN]
Thobois, Stéphane [Auteur]
Institut des sciences cognitives Marc Jeannerod - Centre de neuroscience cognitive - UMR5229 [ISC-MJ]
Metereau, Elise [Auteur]
Institut des sciences cognitives Marc Jeannerod - Centre de neuroscience cognitive - UMR5229 [ISC-MJ]
Mangone, Graziella [Auteur]
Institut du Cerveau = Paris Brain Institute [ICM]
Vidailhet, Marie [Auteur]
Institut du Cerveau = Paris Brain Institute [ICM]
Corvol, Jean-Christophe [Auteur]
Institut du Cerveau = Paris Brain Institute [ICM]
Lehéricy, Stéphanie [Auteur]
Institut du Cerveau = Paris Brain Institute [ICM]
Menjot De Champfleur, Nicolas [Auteur]
Institut d’Imagerie Fonctionnelle Humaine [CHU Montpellier] [I2FH]
Geny, Christian [Auteur]
Centre Hospitalier Régional Universitaire [Montpellier] [CHRU Montpellier]
Spampinato, Umberto [Auteur]
Institut de Neurosciences cognitives et intégratives d'Aquitaine [INCIA]
Meissner, Wassilios G. [Auteur]
Institut des Maladies Neurodégénératives [Bordeaux] [IMN]
Frismand, Solène [Auteur]
Centre Hospitalier Régional Universitaire de Nancy [CHRU Nancy]
Schmitt, Emmanuelle [Auteur]
Doé De Maindreville, Anne [Auteur]
Hôpital Maison Blanche
Portefaix, Christophe [Auteur]
Hôpital Maison Blanche
Remy, Philippe [Auteur]
Institut Mondor de Recherche Biomédicale [IMRB]
Fénelon, Gilles [Auteur]
Institut Mondor de Recherche Biomédicale [IMRB]
Houeto, Jean-Luc [Auteur]
CIC Poitiers – Centre d'investigation clinique de Poitiers [CIC 1402]
Colin, Olivier [Auteur]
CIC Poitiers – Centre d'investigation clinique de Poitiers [CIC 1402]
Rascol, Olivier [Auteur]
Centre d'investigation clinique de Toulouse [CIC 1436]
Peran, Patrice [Auteur]
Toulouse NeuroImaging Center [ToNIC]
Bonny, Jean-Marie [Auteur]
Qualité des Produits Animaux [QuaPA]
Fantini, Maria Livia [Auteur]
Institut Pascal [IP]
Durif, Frank [Auteur]
Institut Pascal [IP]

Journal title :

Journal of Neurology

Abbreviated title :

J Neurol

Volume number :

270

Pages :

6033–6043

Publication date :

2023-09-02

ISSN :

1432-1459

English keyword(s) :

Longitudinal study
Clinical progression
Brain atrophy
Volumetric changes
Parkinson's disease

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Background Longitudinal measures of structural brain changes using MRI in relation to clinical features and progression patterns in PD have been assessed in previous studies, but few were conducted in well-defined and ...
Show more >Background Longitudinal measures of structural brain changes using MRI in relation to clinical features and progression patterns in PD have been assessed in previous studies, but few were conducted in well-defined and large cohorts, including prospective clinical assessments of both motor and non-motor symptoms. Objective We aimed to identify brain volumetric changes characterizing PD patients, and determine whether regional brain volumetric characteristics at baseline can predict motor, psycho-behavioral and cognitive evolution at one year in a prospective cohort of PD patients. Methods In this multicentric 1 year longitudinal study, PD patients and healthy controls from the MPI-R2* cohort were assessed for demographical, clinical and brain volumetric characteristics. Distinct subgroups of PD patients according to motor, cognitive and psycho-behavioral evolution were identified at the end of follow-up. Results One hundred and fifty PD patients and 73 control subjects were included in our analysis. Over one year, there was no significant difference in volume variations between PD and control subjects, regardless of the brain region considered. However, we observed a reduction in posterior cingulate cortex volume at baseline in PD patients with motor deterioration at one year (p = 0.017). We also observed a bilateral reduction of the volume of the amygdala (p = 0.015 and p = 0.041) and hippocampus (p = 0.015 and p = 0.053) at baseline in patients with psycho-behavioral deterioration, regardless of age, dopaminergic treatment and center. Conclusion Brain volumetric characteristics at baseline may predict clinical trajectories at 1 year in PD as posterior cingulate cortex atrophy was associated with motor decline, while amygdala and hippocampus atrophy were associated with psycho-behavioral decline.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Université de Lille
Inserm
CHU Lille

Collections :

• Lille Neurosciences & Cognition (LilNCog) - U 1172

Submission date :

2024-02-06T23:14:34Z
2024-06-03T07:17:15Z