Title :

Poor Bone Quality is Associated With Greater Arterial Stiffness: Insights From the UK Biobank

Author(s) :

Raisi-Estabragh, Zahra [Auteur]
St Bartholomew's Hospital (London)
Queen Mary University of London [QMUL]
William Harvey Research Institute, Barts and the London Medical School
Biasiolli, Luca [Auteur]
University of Oxford
Cooper, Jackie [Auteur]
St Bartholomew's Hospital (London)
Queen Mary University of London [QMUL]
William Harvey Research Institute, Barts and the London Medical School
Aung, Nay [Auteur]
St Bartholomew's Hospital (London)
Queen Mary University of London [QMUL]
William Harvey Research Institute, Barts and the London Medical School
Fung, Kenneth [Auteur]
St Bartholomew's Hospital (London)
Queen Mary University of London [QMUL]
William Harvey Research Institute, Barts and the London Medical School
Paiva, José [Auteur]
Queen Mary University of London [QMUL]
William Harvey Research Institute, Barts and the London Medical School
Sanghvi, Mihir [Auteur]
St Bartholomew's Hospital (London)
Queen Mary University of London [QMUL]
William Harvey Research Institute, Barts and the London Medical School
Thomson, Ross [Auteur]
Royal Free London NHS Foundation Trust
Royal Free Hospital [London, UK]
Curtis, Elizabeth [Auteur]
University of Southampton
Paccou, Julien [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Marrow Adiposity & Bone Lab - Adiposité Médullaire et Os - ULR 4490 [MABLab]
Rayner, Jennifer [Auteur]
University of Oxford
Werys, Konrad [Auteur]
University of Oxford
Puchta, Henrike [Auteur]
University of Oxford
Thomas, Katharine [Auteur]
University of Oxford
Lee, Aaron [Auteur]
Queen Mary University of London [QMUL]
William Harvey Research Institute, Barts and the London Medical School
Piechnik, Stefan [Auteur]
University of Oxford
Neubauer, Stefan [Auteur]
University of Oxford
Munroe, Patricia [Auteur]
Queen Mary University of London [QMUL]
William Harvey Research Institute, Barts and the London Medical School
Cooper, Cyrus [Auteur]
University of Oxford
University Hospital Southampton NHS Foundation Trust
University of Southampton
Petersen, Steffen [Auteur]
St Bartholomew's Hospital (London)
Barts Health NHS Trust [London, UK]
William Harvey Research Institute, Barts and the London Medical School
Harvey, Nicholas [Auteur]
University of Southampton
University Hospital Southampton NHS Foundation Trust

Journal title :

Journal of Bone and Mineral Research

Pages :

90-99

Publisher :

American Society for Bone and Mineral Research

Publication date :

2020-12-01

ISSN :

0884-0431

English keyword(s) :

ARTERIAL STIFFNESS
CARDIOVASCULAR DISEASE
EPIDEMIOLOGY
ISCHEMIC HEART DISEASE
OSTEOPOROSIS

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

ABSTRACT Osteoporosis and ischemic heart disease (IHD) represent important public health problems. Existing research suggests an association between the two conditions beyond that attributable to shared risk factors, with ...
Show more >ABSTRACT Osteoporosis and ischemic heart disease (IHD) represent important public health problems. Existing research suggests an association between the two conditions beyond that attributable to shared risk factors, with a potentially causal relationship. In this study, we tested the association of bone speed of sound (SOS) from quantitative heel ultrasound with (i) measures of arterial compliance from cardiovascular magnetic resonance (aortic distensibility [AD]); (ii) finger photoplethysmography (arterial stiffness index [ASI]); and (iii) incident myocardial infarction and IHD mortality in the UK Biobank cohort. We considered the potential mediating effect of a range of blood biomarkers and cardiometabolic morbidities and evaluated differential relationships by sex, menopause status, smoking, diabetes, and obesity. Furthermore, we considered whether associations with arterial compliance explained association of SOS with ischemic cardiovascular outcomes. Higher SOS was associated with lower arterial compliance by both ASI and AD for both men and women. The relationship was most consistent with ASI, likely relating to larger sample size available for this variable (n = 159,542 versus n = 18,229). There was no clear evidence of differential relationship by menopause, smoking, diabetes, or body mass index (BMI). Blood biomarkers appeared important in mediating the association for both men and women, but with different directions of effect and did not fully explain the observed effects. In fully adjusted models, higher SOS was associated with significantly lower IHD mortality in men, but less robustly in women. The association of SOS with ASI did not explain this observation. In conclusion, our findings support a positive association between bone and vascular health with consistent patterns of association in men and women. The underlying mechanisms are complex and appear to vary by sex. © 2020 The Authors. Journal of Bone and Mineral Research published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research (ASBMR).Show less >

Language :

Anglais

Popular science :

Non

Collections :

• Marrow Adiposity & Bone Lab (MABLab) - ULR 4490

Source :

Harvested from HAL