The Role of Bone Marrow Fat in Skeletal Health: Usefulness and Perspectives for Clinicians

Paccou, Julien; Hardouin, Pierre; Cotten, Anne; Penel, Guillaume; Cortet, Bernard

Document type :

Compte-rendu et recension critique d'ouvrage

DOI :

10.1210/jc.2015-2338

Title :

The Role of Bone Marrow Fat in Skeletal Health: Usefulness and Perspectives for Clinicians

Author(s) :

Paccou, Julien [Auteur]

Université de Lille
Marrow Adiposity & Bone Lab - Adiposité Médullaire et Os - ULR 4490 [MABLab]
Hardouin, Pierre [Auteur]

Université du Littoral Côte d'Opale [ULCO]
Marrow Adiposity & Bone Lab - Adiposité Médullaire et Os - ULR 4490 [MABLab]
Cotten, Anne [Auteur]

Marrow Adiposity & Bone Lab - Adiposité Médullaire et Os - ULR 4490 [MABLab]
Radiologie et Imagerie Musculo-Squelettique [CHU Lille]
Penel, Guillaume [Auteur]

Marrow Adiposity & Bone Lab - Adiposité Médullaire et Os - ULR 4490 [MABLab]
Cortet, Bernard [Auteur]

Marrow Adiposity & Bone Lab - Adiposité Médullaire et Os - ULR 4490 [MABLab]

Journal title :

Journal of Clinical Endocrinology and Metabolism

Pages :

3613-3621

Publisher :

Endocrine Society

Publication date :

2015-10-01

ISSN :

0021-972X

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Context: There is growing interest in the relationship between bone marrow fat (BMF), bone mineral density (BMD), and fractures. Moreover, BMF might be influenced by metabolic diseases associated with bone loss and fractures, ...
Show more >Context: There is growing interest in the relationship between bone marrow fat (BMF), bone mineral density (BMD), and fractures. Moreover, BMF might be influenced by metabolic diseases associated with bone loss and fractures, such as type 2 diabetes mellitus (T2DM), anorexia nervosa (AN), and obesity. Methods: The primary-source literature for this review was acquired using a PubMed search for articles published between January 2000 and April 2015. Search terms included BMF, BMD, fractures, T2DM, AN, and obesity. The titles and abstracts of all articles were reviewed for relevant subjects. Results: Magnetic resonance imaging, with or without spectroscopy, was used to noninvasively quantify BMF in humans. A negative relationship was found between BMD and BMF in both healthy and osteopenic/osteoporotic populations. Data are lacking on the relationship between BMF and fractures. Studies in populations of individuals with metabolic diseases such as T2DM, AN, and obesity have shown BMF abnormalities. Conclusions: We conclude that most human data demonstrate an inverse relationship between BMF and BMD, but data on the relationship with fractures are inconsistent and need further study. In daily practice, the usefulness for clinicians of assessing BMF using magnetic resonance imaging is still limited. However, the perspectives are exciting, particularly in terms of improving the diagnosis and management of osteoporosis.Show less >

Language :

Anglais

Popular science :

Non

Collections :

Marrow Adiposity & Bone Lab (MABLab) - ULR 4490

Source :

Harvested from HAL

Files

jcem3613.pdf
Open access
Access the document

The Role of Bone Marrow Fat in Skeletal ... BibTeX CSV Excel RIS

Files

The Role of Bone Marrow Fat in Skeletal ...

BibTeX

CSV

Excel

RIS