Titre :

Cytotoxicity and effectiveness of archetypal Metal-Organic Frameworks (HKUST-1, UiO-66, MIL-53, MIL-125) against coronaviruses (HCoV-229E and SARS-CoV-2)

Auteur(s) :

Plastiras, Orfeas-Evangelos [Auteur]
Unité de Catalyse et Chimie du Solide - UMR 8181 [UCCS]
Bouquet, Peggy [Auteur]
Plateformes Lilloises en Biologie et Santé - UAR 2014 - US 41 [PLBS]
Lecoeur, Cecile [Auteur]
Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL]
Dhainaut, Jérémy [Auteur]
Unité de Catalyse et Chimie du Solide - UMR 8181 [UCCS]
Dacquin, Jean-Philippe [Auteur]
Unité de Catalyse et Chimie du Solide - UMR 8181 [UCCS]
Royer, sebastien [Auteur]
Unité de Catalyse et Chimie du Solide - UMR 8181 [UCCS]
Loiseau, Thierry [Auteur]
Unité de Catalyse et Chimie du Solide - UMR 8181 [UCCS]
Goffard, Anne [Auteur]
Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL]
Volkringer, Christophe [Auteur]
Unité de Catalyse et Chimie du Solide - UMR 8181 [UCCS]

Titre de la revue :

Microporous and Mesoporous Materials

Pagination :

112975

Éditeur :

Elsevier

Date de publication :

2024-03-01

ISSN :

1387-1811

Mot(s)-clé(s) en anglais :

Metal-Organic Framework Cytotoxicity SARS-CoV-2 HCoV-229E Coronaviruses
Metal-Organic Framework
Cytotoxicity
SARS-CoV-2
HCoV-229E
Coronaviruses

Discipline(s) HAL :

Chimie/Chimie organique

Résumé en anglais : [en]

In order to use MOFs in virus decontamination processes, four archetypal MOFs with different metal clusters have been chosen: UiO-66 (Zr), HKUST-1 (Cu), MIL-53 (Fe) and MIL-125 (Ti). Five different concentrations (from ...
Lire la suite >In order to use MOFs in virus decontamination processes, four archetypal MOFs with different metal clusters have been chosen: UiO-66 (Zr), HKUST-1 (Cu), MIL-53 (Fe) and MIL-125 (Ti). Five different concentrations (from 0.01 to 1 mg/mL) for each MOF and three different cell lines (Huh7 TMPRSS2, VeroE6 and Vero81.6) were investigated in aqueous medium (DMEM). Moreover, different cytotoxicity assays were evaluated (MTS, Neutral Red and LDH) and critically compared for the first time, with Neutral Red seemingly to be the most appropriate. HKUST-1 was found to be toxic above 0.1 mg/mL for all of the three cell lines, while the other three MOFs appear to be nontoxic, even above 1 mg/mL. Then, their effect against viruses was monitored, mainly for HCoV-229E and SARS-CoV-2, two different coronaviruses that still cause a lot of infection cases and deaths up to now. Following 1 hour contact with the viruses, HKUST-1 (Cu) and MIL-125 (Ti) were able to greatly diminish the viral titer by 86% and 79.2%, respectively, for HCoV-229E, whereas for SARS-CoV-2 HKUST-1 (Cu), MIL-53 (Fe) and UiO-66 (Zr), demonstrated an efficacy of 68.4%, 63.1% and 56.1%, respectively.Lire moins >

Langue :

Anglais

Comité de lecture :

Oui

Audience :

Internationale

Vulgarisation :

Non

Collections :

• Centre d'Infection et d'Immunité de Lille (CIIL) - U1019 - UMR 9017

Source :

Harvested from HAL