NOD-like receptors in asthma

Alvarez-Simon, Daniel; Ait Yahia, Saliha; de Nadai, Patricia; Audousset, Camille; Chamaillard, Mathias; Boneca, Ivo Gomperts; Tsicopoulos, Anne

Document type :

Article dans une revue scientifique: Article original

DOI :

10.3389/fimmu.2022.928886

PMID :

36189256

Title :

NOD-like receptors in asthma

Author(s) :

Alvarez-Simon, Daniel [Auteur]
Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL]
Ait Yahia, Saliha [Auteur]
Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL]
de Nadai, Patricia [Auteur]
Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL]
Audousset, Camille [Auteur]
Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL]
Chamaillard, Mathias [Auteur]

Laboratoire de Physiologie Cellulaire - U 1003 [PHYCELL]
Boneca, Ivo Gomperts [Auteur]
Biologie et Génétique de la Paroi bactérienne - Biology and Genetics of Bacterial Cell Wall
Tsicopoulos, Anne [Auteur]

Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL]

Journal title :

Frontiers in Immunology

Pages :

928886

Publisher :

Frontiers

Publication date :

2022-09-14

ISSN :

1664-3224

HAL domain(s) :

Sciences du Vivant [q-bio]
Sciences du Vivant [q-bio]/Immunologie

English abstract : [en]

Asthma is an extremely prevalent chronic inflammatory disease of the airway where innate and adaptive immune systems participate collectively with epithelial and other structural cells to cause airway hyperresponsiveness, ...
Show more >Asthma is an extremely prevalent chronic inflammatory disease of the airway where innate and adaptive immune systems participate collectively with epithelial and other structural cells to cause airway hyperresponsiveness, mucus overproduction, airway narrowing, and remodeling. The nucleotide-binding oligomerization domain (NOD)-like receptors (NLRs) are a family of intracellular innate immune sensors that detect microbe-associated molecular patterns and damage-associated molecular patterns, well-recognized for their central roles in the maintenance of tissue homeostasis and host defense against bacteria, viruses and fungi. In recent times, NLRs have been increasingly acknowledged as much more than innate sensors and have emerged also as relevant players in diseases classically defined by their adaptive immune responses such as asthma. In this review article, we discuss the current knowledge and recent developments about NLR expression, activation and function in relation to asthma and examine the potential interventions in NLR signaling as asthma immunomodulatory therapies.Show less >

Language :

Anglais

Peer reviewed article :

Oui

Audience :

Internationale

Popular science :

Non

ANR Project :

Déterminants moléculaires de sensibilisation à l'asthme allergique et innovation thérapeutique

Collections :