Title :

Circadian misalignment induces fatty acid metabolism gene profiles and compromises insulin sensitivity in human skeletal muscle

Author(s) :

Wefers, Jakob [Auteur]
van Moorsel, Dirk [Auteur]
Hansen, Jan [Auteur]
Connell, Niels [Auteur]
Havekes, Bas [Auteur]
Maastricht University Medical Centre [MUMC]
Hoeks, Joris [Auteur]
Maastricht University [Maastricht]
van Marken Lichtenbelt, Wouter [Auteur]
Maastricht University [Maastricht]
Duez, Hélène [Auteur]
Récepteurs Nucléaires, Maladies Métaboliques et Cardiovasculaires - U 1011 [RNMCD]
Récepteurs nucléaires, maladies cardiovasculaires et diabète - U 1011 [RNMCD]
Phielix, Esther [Auteur]
Maastricht University [Maastricht]
Kalsbeek, Andries [Auteur]
Boekschoten, Mark [Auteur]
Top Institute Food and Nutrition [TIFN]
Hooiveld, Guido [Auteur]
Maastricht University [Maastricht]
Hesselink, Matthijs [Auteur]
Maastricht University [Maastricht]
Kersten, Sander [Auteur]
Staels, Bart [Auteur]
Récepteurs Nucléaires, Maladies Métaboliques et Cardiovasculaires - U 1011 [RNMCD]
Institut Européen de Génomique du Diabète - European Genomic Institute for Diabetes - FR 3508 [EGID]
Récepteurs nucléaires, maladies cardiovasculaires et diabète - U 1011 [RNMCD]
Scheer, Frank [Auteur]
Harvard Medical School [Boston] [HMS]
Schrauwen, Patrick [Auteur]
Maastricht University [Maastricht]

Journal title :

Proceedings of the National Academy of Sciences of the United States of America

Pages :

7789-7794

Publisher :

National Academy of Sciences

Publication date :

2018-07-09

ISSN :

0027-8424

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Significance Shift workers are affected by circadian misalignment and have an increased risk to develop metabolic diseases such as type 2 diabetes. Here, we show that during simulated short-term night shift work insulin ...
Show more >Significance Shift workers are affected by circadian misalignment and have an increased risk to develop metabolic diseases such as type 2 diabetes. Here, we show that during simulated short-term night shift work insulin sensitivity at the level of skeletal muscle is decreased in male volunteers, which could contribute to the development of type 2 diabetes in the long term. We also find that the muscle molecular clock does not align rapidly to the new behavioral cycle. Importantly, on the level of the transcriptome, circadian misalignment induced upregulation of fatty acid metabolism pathways, potentially resulting in substrate competition on the cellular level. These findings help to better understand the negative consequences during night shift work.Show less >

Language :

Anglais

Peer reviewed article :

Oui

Audience :

Internationale

Popular science :

Non

Collections :

• Récepteurs nucléaires, Maladies Cardiovasculaires et Diabète (RNMCD) - U1011

Source :

Harvested from HAL