Titre :

Impact of Pre-Existing History of Heart Failure on Patient Profile, Therapeutic Management, and Prognosis in Cardiogenic Shock: Insights from the FRENSHOCK Registry

Auteur(s) :

Schurtz, Guillaume [Auteur]
Delmas, Clément [Auteur]
Fenouillet, Margaux [Auteur]
Roubille, François [Auteur]
Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] [PhyMedExp]
Centre Hospitalier Régional Universitaire [Montpellier] [CHRU Montpellier]
Puymirat, Etienne [Auteur]
Bonello, Laurent [Auteur]
Leurent, Guillaume [Auteur]
Verdier, Basile [Auteur]
Levy, Bruno [Auteur]
Ternacle, Julien [Auteur]
Harbaoui, Brahim [Auteur]
Vanzetto, Gerald [Auteur]
Combaret, Nicolas [Auteur]
Lattuca, Benoît [Auteur]
Bruel, Cedric [Auteur]
Bourenne, Jeremy [Auteur]
Labbé, Vincent [Auteur]
Henry, Patrick [Auteur]
Bonnefoy-Cudraz, Éric [Auteur]
Lamblin, Nicolas [Auteur]
Lemesle, Gilles [Auteur]
Récepteurs Nucléaires, Maladies Métaboliques et Cardiovasculaires - U 1011 [RNMCD]

Titre de la revue :

Life

Pagination :

1844

Éditeur :

MDPI

Date de publication :

2022-11-11

ISSN :

2075-1729

Discipline(s) HAL :

Sciences du Vivant [q-bio]

Résumé en anglais : [en]

There is a large heterogeneity among patients presenting with cardiogenic shock (CS). It is crucial to better apprehend this heterogeneity in order to adapt treatments and improve prognoses in these severe patients. Notably, ...
Lire la suite >There is a large heterogeneity among patients presenting with cardiogenic shock (CS). It is crucial to better apprehend this heterogeneity in order to adapt treatments and improve prognoses in these severe patients. Notably, the presence (or absence) of a pre-existing history of chronic heart failure (CHF) at time of CS onset may be a significant part of this heterogeneity, and data focusing on this aspect are lacking. We aimed to compare CS patients with new-onset HF to those with worsening CHF in the multicenter FRENSHOCK registry. Altogether, 772 CS patients were prospectively included: 433 with a previous history of CHF and 339 without. Worsening CHF patients were older (68 +/− 13.4 vs. 62.7 +/− 16.2, p < 0.001) and had a greater burden of extra-cardiac comorbidities. At admission, acute myocardial infarction was predominantly observed in the new-onset HF group (49.9% vs. 25.6%, p < 0.001). When focusing on hemodynamic parameters, worsening CHF patients showed more congestion and higher ventricular filling pressures. Worsening CHF patients experienced higher in-hospital all-cause mortality (31.3% vs. 24.2%, p = 0.029). Our results emphasize the great heterogeneity of the patients presenting with CS. Worsening CHF patients had higher risk profiles, and this translated to a 30% increase in in-hospital all-cause mortality. The heterogeneity of this population prompts us to better determine the phenotype of CS patients to adapt their management.Lire moins >

Langue :

Anglais

Vulgarisation :

Non

Collections :

• Récepteurs nucléaires, Maladies Cardiovasculaires et Diabète (RNMCD) - U1011

Source :

Harvested from HAL