Titre :

Seizures after decompressive hemicraniectomy for large middle cerebral artery territory infarcts: incidence, associated factors and impact on long-term outcomes

Auteur(s) :

Masheka Cishesa, Olivier [Auteur]
Kyheng, Maéva [Auteur]
Cordonnier, Charlotte [Auteur]
Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer - U837 [JPArc]
Kuchcinski, Gregory [Auteur]
Lille Neurosciences & Cognition - U 1172 [LilNCog]
Chochoi, M. [Auteur]
Lejeune, Jean-Paul [Auteur]
Thérapies Assistées par Lasers et Immunothérapies pour l'Oncologie - U 1189 [OncoThAI]
Henon, Hilde [Auteur]
Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer - U837 [JPArc]
Casolla, Barbara [Auteur]
Equipe Alzheimer and Tauopathies - LilNCog [U1172 Inserm]

Titre de la revue :

EUROPEAN JOURNAL OF NEUROLOGY

Pagination :

p. 2745-2755

Date de publication :

2021-08-01

ISSN :

1468-1331

Mot(s)-clé(s) en anglais :

hemicraniectomy
long&#8208
term outcome
mortality
poststroke seizures
stroke

Discipline(s) HAL :

Sciences du Vivant [q-bio]

Résumé en anglais : [en]

Background and purposeDecompressive hemicraniectomy (DH) reduces mortality of large middle cerebral artery (MCA) territory infarcts. Survivors are at high risk of poststroke seizures (PSSs). This study aims to describe the ...
Lire la suite >Background and purposeDecompressive hemicraniectomy (DH) reduces mortality of large middle cerebral artery (MCA) territory infarcts. Survivors are at high risk of poststroke seizures (PSSs). This study aims to describe the incidence of PSSs, to identify associated factors, and to assess their impact on long-term outcomes.MethodsWe included consecutive patients who underwent DH for large MCA infarcts from May 2005 to December 2019 at Lille University Hospital. Patients were followed up at 3 months, 1 year, and 3 years. We analysed (i) the incidence and associated factors of early onset PSSs (EPSSs) with logistic regression models; (ii) the incidence and associated factors of late onset PSSs (LPSSs) in survivors at 7 days with a univariate Cox proportional hazard regression model for interval-censored data; and (iii) the impact of PSSs (EPSSs and LPSSs) on mortality with univariate and multivariate Cox proportional hazard regression models and modified Rankin Scale at 1 and 3 years, with univariate and adjusted multivariate ordinal logistic regression analyses.ResultsOf 248 patients (150 men, 60.5%; mean age = 50.4 ± 9.6 years), 106 (42.7%) presented PSSs (six inaugural seizures, 22 EPSSs, 78 LPSSs) during follow-up. The PSS cumulative incidence was 12.3% at 7 days, 24.9% at 3 months, 49.8% at 1 years, and 54.8% at 3 years. No predictor was significantly associated with either EPSSs or LPSSs. PSSs did not significantly impact mortality and long-term functional outcome.ConclusionsThe incidence of PSSs after DH is high, reaching more than 50% 3 years after stroke, but PSSs did not influence long-term mortality or functional outcome.Lire moins >

Langue :

Anglais

Vulgarisation :

Non

Collections :

• Thérapies Lasers Assistées par l'Image pour l'Oncologie (ONCO-THAI) - U1189

Source :

Harvested from HAL