Titre :

Spectral and lifetime endomicroscopic measurements using one and two-photon excitation

Auteur(s) :

Ibrahim, A [Auteur]
Imagerie et Modélisation en Neurobiologie et Cancérologie [IMNC (UMR_8165)]
Poulon, F [Auteur]
Imagerie et Modélisation en Neurobiologie et Cancérologie [IMNC (UMR_8165)]
Zanello, M [Auteur]
Imagerie et Modélisation en Neurobiologie et Cancérologie [IMNC (UMR_8165)]
Habert, R [Auteur]
Laboratoire de Physique des Lasers, Atomes et Molécules - UMR 8523 [PhLAM]
Varlet, P [Auteur]
Devaux, B [Auteur]
Kudlinski, A [Auteur]
Laboratoire de Physique des Lasers, Atomes et Molécules - UMR 8523 [PhLAM]
Abi Haidar, D [Auteur]
Université Paris Diderot - Paris 7 [UPD7]

Titre de la manifestation scientifique :

SPIE BIOS 2017

Ville :

San Francisco

Pays :

Etats-Unis d'Amérique

Date de début de la manifestation scientifique :

2017-01-31

Discipline(s) HAL :

Physique [physics]

Résumé en anglais : [en]

Current surgical biopsy needs several days for the analysis process to be finished. Anatomopathologists provide analysis reports to the surgeon a few days after the surgical intervention, which makes it a lengthy decision ...
Lire la suite >Current surgical biopsy needs several days for the analysis process to be finished. Anatomopathologists provide analysis reports to the surgeon a few days after the surgical intervention, which makes it a lengthy decision making practice. In addition, the lack of precise guidance often leads to inaccuracies in the selection of tissue regions for biopsy and so necessitates repeating the operation sometimes. Our project aims at reducing this time as well as patient discomfort. In this context, we propose to develop a multimodal nonlinear endomicroscope providing several means of contrast. Among these contrast that are useful in the detection of tumor regions, we note imaging by linear and non-linear fluorescence, by second and third harmonic generation and by reflectance. In addition, this technique allows fluorescence lifetime and spectral measurements. Our endomicroscopic system is based on a new homemade customized double-clad photonic crystal fiber (DC-PCF). Finally, this double-clad micro structured optical fiber insures visible and near infrared excitation. This system was tested by measuring fluorescence lifetime and the spectral shape of a fixed tumoral brain sample in one and two photon excitations.Lire moins >

Langue :

Anglais

Comité de lecture :

Non

Audience :

Internationale

Vulgarisation :

Non

Projet ANR :

Fibres optiques pour les hauts Flux
France Life Imaging
Centre Européen pour les Mathématiques, la Physique et leurs Interactions

Collections :

• Laboratoire de Physique des Lasers, Atomes et Molécules (PhLAM) - UMR 8523

Source :

Harvested from HAL