Title :

Nuclear Receptors and Clock Components in Cardiovascular Diseases

Author(s) :

Pourcet, Benoit [Auteur correspondant]
Récepteurs Nucléaires, Maladies Métaboliques et Cardiovasculaires - U 1011 [RNMCD]
Institut Européen de Génomique du Diabète - European Genomic Institute for Diabetes - FR 3508 [EGID]
Duez, Helene [Auteur correspondant]
Récepteurs Nucléaires, Maladies Métaboliques et Cardiovasculaires - U 1011 [RNMCD]
Institut Européen de Génomique du Diabète - European Genomic Institute for Diabetes - FR 3508 [EGID]

Journal title :

International Journal of Molecular Sciences

Pages :

9721

Publisher :

MDPI

Publication date :

2021-09-08

ISSN :

1661-6596

English keyword(s) :

atherosclerosis
cardiovascular diseases
circadian rhythm
chronobiology
nuclear recep- tors
Rev-erb
ROR
inflammation

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Cardiovascular diseases (CVD) are still the first cause of death worldwide. Their main origin is the development of atherosclerotic plaque, which consists in the accumulation of lipids and inflammatory leucocytes within ...
Show more >Cardiovascular diseases (CVD) are still the first cause of death worldwide. Their main origin is the development of atherosclerotic plaque, which consists in the accumulation of lipids and inflammatory leucocytes within the vascular wall of large vessels. Beyond dyslipidemia, diabetes, obesity, hypertension and smoking, the alteration of circadian rhythms, in shift workers for instance, has recently been recognized as an additional risk factor. Accordingly, targeting a pro-atherogenic pathway at the right time window, namely chronotherapy, has proven its efficiency in reducing plaque progression without affecting healthy tissues in mice, thus providing the rationale of such an approach to treat CVD and to reduce drug side effects. Nuclear receptors are transcriptional factors involved in the control of many physiological processes. Among them, Rev-erbs and RORs control metabolic homeostasis, inflammatory processes and the biological clock. In this review, we discuss the opportunity to dampen atherosclerosis progression by targeting such ligand-activated core clock components in a (chrono-)therapeutic approach in order to treat CVD.Show less >

Language :

Anglais

Peer reviewed article :

Oui

Audience :

Internationale

Popular science :

Non

ANR Project :

Conséquences du dysfonctionnement du rythme circadien lié à l'âge sur les défenses immunitaires innées contre les infections respiratoires
Intégrer les spécificités moléculaires liées au sexe pour une prise en charge personnalisée des hépatopathies métaboliques
EGID Diabetes Pole
ULNE

Collections :

• Récepteurs nucléaires, Maladies Cardiovasculaires et Diabète (RNMCD) - U1011

Source :

Harvested from HAL