Title :

Evolution of Cognitive Impairments in Treatment-Resistant Depression: Results from the Longitudinal French Centers of Expertise for Treatment-Resistant Depression (FACE-DR) Cohort.

Author(s) :

Vancappel, A. [Auteur]
Centre Hospitalier Régional Universitaire de Tours [CHRU Tours]
Dansou, Y. [Auteur]
Fondation FondaMental [Créteil]
Godin, O. [Auteur]
Haffen, E. [Auteur]
Yrondi, A. [Auteur]
Stephan, F. [Auteur]
Richieri, R. M. [Auteur]
Molière, F. [Auteur]
Holtzmann, J. [Auteur]
Horn, Mathilde [Auteur]
Fondation FondaMental [Créteil]
Allauze, E. [Auteur]
Genty, J. B. [Auteur]
Bouvard, A. [Auteur]
Dorey, J. M. [Auteur]
Hennion, V. [Auteur]
Camus, V. [Auteur]
Fond, G. [Auteur]
Peran, B. [Auteur]
Walter, M. [Auteur]
Anguill, L. [Auteur]
Scotto D'apolina, C. [Auteur]
Vilà, E. [Auteur]
Fredembach, B. [Auteur]
Petrucci, J. [Auteur]
Rey, R. [Auteur]
Nguon, A. S. [Auteur]
Etain, B. [Auteur]
Carminati, M. [Auteur]
Courtet, P. [Auteur]
Vaiva, Guillaume [Auteur]
Lille Neurosciences & Cognition (LilNCog) - U 1172
Llorca, P. M. [Auteur]
Leboyer, M. [Auteur]
Aouizerate, B. [Auteur]
Bennabi, D. [Auteur]
El Hage, W. [Auteur]
Centre Hospitalier Régional Universitaire de Tours [CHRU Tours]

Journal title :

Brain Sciences

Abbreviated title :

Brain Sci

Volume number :

13

Pages :

1120

Publisher :

MDPI

Publication date :

2023-07-24

ISSN :

2076-3425

English keyword(s) :

processing speed
executive function
memory
neuropsychology
cognitive impairments
treatment-resistant depression

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Previous studies set out profound cognitive impairments in subjects with treatment-resistant depression (TRD). However, little is known about the course of such alterations depending on levels of improvement in those ...
Show more >Previous studies set out profound cognitive impairments in subjects with treatment-resistant depression (TRD). However, little is known about the course of such alterations depending on levels of improvement in those patients followed longitudinally. The main objective of this study was to describe the course of cognitive impairments in responder versus non-responder TRD patients at one-year follow-up. The second aim was to evaluate the predictive aspect of cognitive impairments to treatment resistance in patients suffering from TRD. We included 131 patients from a longitudinal cohort (FACE-DR) of the French Network of Expert TRD Centers. They undertook comprehensive sociodemographic, clinical, global functioning, and neuropsychological testing (TMT, Baddeley task, verbal fluencies, WAIS-4 subtests, D2 and RLRI-16) at baseline (V0) and one-year follow-up (V1). Most patients (n = 83; 63.36%) did not respond (47 women, 49.47 ± 12.64 years old), while one-third of patients responded (n = 48, 30 women, 54.06 ± 12.03 years old). We compared the cognitive performances of participants to average theoretical performances in the general population. In addition, we compared the cognitive performances of patients between V1 and V0 and responder versus non-responder patients at V1. We observed cognitive impairments during the episode and after a therapeutic response. Overall, each of them tended to show an increase in their cognitive scores. Improvement was more prominent in responders at V1 compared to their non-responder counterparts. They experienced a more marked improvement in code, digit span, arithmetic, similarities, and D2 tasks. Patients suffering from TRD have significant cognitive impairments that persist but alleviate after therapeutic response. Cognitive remediation should be proposed after therapeutic response to improve efficiency and increase the daily functioning.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Université de Lille
Inserm
CHU Lille

Collections :

• Lille Neurosciences & Cognition (LilNCog) - U 1172

Submission date :

2024-03-12T22:06:03Z
2024-12-04T09:31:26Z