Title :

French guidelines for the etiological workup of eosinophilia and the management of hypereosinophilic syndromes

Author(s) :

Groh, Matthieu [Auteur]
Institute for Translational Research in Inflammation - U 1286 [INFINITE]
Rohmer, Julien [Auteur]
Etienne, Nicolas [Auteur]
Abou Chahla, Wadih [Auteur]
Baudet, Antoine [Auteur]
Chan Hew Wai, Aurélie [Auteur]
Chenivesse, Cécile [Auteur]
Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL]
Clisson Rusek, Irena [Auteur]
Cottin, Vincent [Auteur]
Infections Virales et Pathologie Comparée - UMR 754 [IVPC]
Decamp, Matthieu [Auteur]
Service de Génétique [CHU Caen]
Biologie, génétique et thérapies ostéoarticulaires et respiratoires [BIOTARGEN]
De Groote, Pascal [Auteur]
Facteurs de Risque et Déterminants Moléculaires des Maladies liées au Vieillissement - U 1167 [RID-AGE]
Delahousse, Fanny [Auteur]
Duployez, Nicolas [Auteur]
Hétérogénéité, Plasticité et Résistance aux Thérapies des Cancers = Cancer Heterogeneity, Plasticity and Resistance to Therapies - UMR 9020 - U 1277 [CANTHER]
Faguer, Stanislas [Auteur]
Gottrand, Frédéric [Auteur]
Institute for Translational Research in Inflammation - U 1286 [INFINITE]
Huang, Florent [Auteur]
Leblanc, Thierry [Auteur]
Magnan, Antoine [Auteur]
Virologie et Immunologie Moléculaires [VIM (UR 0892)]
Service de pneumologie [Hôpital Foch]
Université de Versailles Saint-Quentin-en-Yvelines [UVSQ]
Martin, Thierry [Auteur]
Mortuaire, Geoffrey [Auteur]
Institute for Translational Research in Inflammation - U 1286 [INFINITE]
Néel, Antoine [Auteur]
Paris, Luc [Auteur]
Petit, Arnaud [Auteur]
Rossignol, Julien [Auteur]
Schleinitz, Nicolas [Auteur]
Soret-Dulphy, Juliette [Auteur]
Staumont-Salle, Delphine [Auteur]
Institute for Translational Research in Inflammation - U 1286 [INFINITE]
Terrier, Benjamin [Auteur]
Terriou, Louis [Auteur]
Institute for Translational Research in Inflammation - U 1286 [INFINITE]
Viallard, Jean-François [Auteur]
Lefèvre, Guillaume [Auteur]
Institute for Translational Research in Inflammation - U 1286 [INFINITE]
Kahn, Jean-Emmanuel [Auteur]
Institute for Translational Research in Inflammation - U 1286 [INFINITE]

Journal title :

Orphanet journal of rare diseases

Pages :

100

Publisher :

BioMed Central

Publication date :

2023-12

ISSN :

1750-1172

English keyword(s) :

Hypereosinophilia
Hypereosinophilic syndromes
Recommendation
Management

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Abstract Eosinophilic-related clinical manifestations are protean and the underlying conditions underpinning eosinophilia are highly diverse. The etiological workup of unexplained eosinophilia/hypereosinophilia can be ...
Show more >Abstract Eosinophilic-related clinical manifestations are protean and the underlying conditions underpinning eosinophilia are highly diverse. The etiological workup of unexplained eosinophilia/hypereosinophilia can be challenging, and can lead sometimes to extensive, inappropriate, costly and/or invasive investigations. To date, guidelines for the etiological workup and management of eosinophilia are mainly issued by hematologists, and thus mostly cover the scope of clonal hypereosinophilic syndromes (HES). Here, thanks to an extensive literature review, and thanks to the joint work of a large panel of experts involving physicians from both adult and pediatric medicine and from various subspecialties (as well as a representative of a patients’ association representative), we provide recommendations for both the step-by step diagnostic workup of eosinophilia (whether unexplained or within specific contexts) as well as the management and follow-up of the full spectrum of eosinophilic disorders (including clonal, reactive, lymphocytic and idiopathic HES, as well as single-organ diseases). Didactic prescription summaries intended to facilitate the prescription of eosinophil-targeted drugs are also provided, as are practical diagnostic and therapeutic algorithms. Lastly, this set of recommendations also includes a summary intended for general practitioners, as well as an overview of the therapeutic patient education program set up by the French reference center for HES. Further updates will be mandatory as new validated information emerges.Show less >

Language :

Anglais

Peer reviewed article :

Oui

Audience :

Internationale

Popular science :

Non

Collections :

• Centre d'Infection et d'Immunité de Lille (CIIL) - U1019 - UMR 9017

Source :

Harvested from HAL