Bioinformatics tools to analyse non-ribosomal ...
Document type :
Autre communication scientifique (congrès sans actes - poster - séminaire...): Communication dans un congrès avec actes: Conférence invitée
Title :
Bioinformatics tools to analyse non-ribosomal peptides and other metabolites
Author(s) :
Pupin, Maude [Auteur]
Centre de Recherche en Informatique, Signal et Automatique de Lille - UMR 9189 [CRIStAL]
Centre de Recherche en Informatique, Signal et Automatique de Lille - UMR 9189 [CRIStAL]
Conference title :
Symposium Natural Products (Meta)Genome Mining
Conference organizers(s) :
Novo Nordisk Foundation Science Cluster
City :
Copenhagen
Country :
Danemark
Start date of the conference :
2022-05-30
English keyword(s) :
non-ribosomal peptides
metabolites
Computational biology and chemistry
metabolites
Computational biology and chemistry
HAL domain(s) :
Chimie/Chemo-informatique
Informatique [cs]/Bio-informatique [q-bio.QM]
Informatique [cs]/Bio-informatique [q-bio.QM]
English abstract : [en]
Secondary metabolites are in between small molecules and sequences, as they are composed by monomers (amino acids, sugars, lipids, etc.) but are not always linear. We design a specific notation to describe the monomeric ...
Show more >Secondary metabolites are in between small molecules and sequences, as they are composed by monomers (amino acids, sugars, lipids, etc.) but are not always linear. We design a specific notation to describe the monomeric structure: a graph in which the nodes are the monomers and the edges are the chemical bonds between them (ex: peptide bonds). This notation helps linking a metabolite to its biosynthetic gene cluster, when its synthesis is an assembly of monomers. We conceived tools to analyse and visualize secondary metabolites, based on this notation. s2m and rBAN infer a monomeric structure from a chemical structure. Kendrick Formula Predictor and NRPro help analysing mass spectrometry results. And Norine is a database dedicated to non-ribosomal peptides. It can be queried by annotations or monomeric structures. https://bioinfo.cristal.univ-lille.fr/NRP/Show less >
Show more >Secondary metabolites are in between small molecules and sequences, as they are composed by monomers (amino acids, sugars, lipids, etc.) but are not always linear. We design a specific notation to describe the monomeric structure: a graph in which the nodes are the monomers and the edges are the chemical bonds between them (ex: peptide bonds). This notation helps linking a metabolite to its biosynthetic gene cluster, when its synthesis is an assembly of monomers. We conceived tools to analyse and visualize secondary metabolites, based on this notation. s2m and rBAN infer a monomeric structure from a chemical structure. Kendrick Formula Predictor and NRPro help analysing mass spectrometry results. And Norine is a database dedicated to non-ribosomal peptides. It can be queried by annotations or monomeric structures. https://bioinfo.cristal.univ-lille.fr/NRP/Show less >
Language :
Anglais
Peer reviewed article :
Non
Audience :
Internationale
Popular science :
Non
Collections :
Source :