Identification of non-volatile non-intentionally ...
Document type :
Article dans une revue scientifique: Article original
PMID :
Permalink :
Title :
Identification of non-volatile non-intentionally added substances from polyester food contact coatings and genotoxicity assessment of polyester coating's migrates.
Author(s) :
Hayrapetyan, Ruzanna [Auteur]
Equipe NuTox (LNC - U1231) [NUTOX]
Cariou, Ronan [Auteur]
Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement [INRAE]
École nationale vétérinaire, agroalimentaire et de l'alimentation Nantes-Atlantique [ONIRIS]
Laboratoire d'étude des Résidus et Contaminants dans les Aliments [LABERCA]
Platel, Anne [Auteur]
IMPact de l'Environnement Chimique sur la Santé humaine (IMPECS) - ULR 4483
Santos, Julie [Auteur]
Impact de l'environnement chimique sur la santé humaine - ULR 4483 [IMPECS]
Huot, Ludovic [Auteur]
Impact de l'environnement chimique sur la santé humaine - ULR 4483 [IMPECS]
Monneraye, Véronique [Auteur]
Chagnon, Marie-Christine [Auteur]
Equipe NuTox (LNC - U1231) [NUTOX]
Severin, Isabelle [Auteur]
Equipe NuTox (LNC - U1231) [NUTOX]
Equipe NuTox (LNC - U1231) [NUTOX]
Cariou, Ronan [Auteur]
Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement [INRAE]
École nationale vétérinaire, agroalimentaire et de l'alimentation Nantes-Atlantique [ONIRIS]
Laboratoire d'étude des Résidus et Contaminants dans les Aliments [LABERCA]
Platel, Anne [Auteur]
![refId](/themes/Mirage2//images/idref.png)
IMPact de l'Environnement Chimique sur la Santé humaine (IMPECS) - ULR 4483
Santos, Julie [Auteur]
Impact de l'environnement chimique sur la santé humaine - ULR 4483 [IMPECS]
Huot, Ludovic [Auteur]
Impact de l'environnement chimique sur la santé humaine - ULR 4483 [IMPECS]
Monneraye, Véronique [Auteur]
Chagnon, Marie-Christine [Auteur]
Equipe NuTox (LNC - U1231) [NUTOX]
Severin, Isabelle [Auteur]
Equipe NuTox (LNC - U1231) [NUTOX]
Journal title :
Food Chem Toxicol
Abbreviated title :
Food Chem Toxicol
Volume number :
185
Pages :
114484
Publisher :
Elsevier
Publication date :
2024-01-29
ISSN :
1873-6351
English keyword(s) :
Food contact materials
Polyester coatings
Hazard identification
Oligoesters
Food safety
Polyester coatings
Hazard identification
Oligoesters
Food safety
HAL domain(s) :
Sciences du Vivant [q-bio]
English abstract : [en]
Can's polyester coatings are intended to replace epoxy-phenolic ones due to rising safety concern regarding the potential release of bisphenol A under increased regulations and consumer pressure. In this study, hazard ...
Show more >Can's polyester coatings are intended to replace epoxy-phenolic ones due to rising safety concern regarding the potential release of bisphenol A under increased regulations and consumer pressure. In this study, hazard linked to the migration of non-intentionally added substances from a single polyester-coated tin plate (5 batches) to canned food has been studied. Migration tests were performed using acetonitrile (ACN) and ethanol (EtOH) 95 %. Non-targeted analyses by liquid chromatography–high-resolution mass spectrometry revealed the presence of four cyclic oligoesters classified as Cramer class III substances with an estimated exposure (calculated for French population only) below the threshold of toxicological concern value of 1.5 μg/kg b.w./day, suggesting a no safety concern. Moreover, migrates were tested using in vitro genotoxicity DNA damage response (DDR) test and mini mutagenicity test (MMT) with different strains of S. Typhimurium using direct incorporation (TA100, TA98, TA102, TA1537) and pre-incubation (TA100, TA98) methods. Samples were negative in both bioassays suggesting the absence of genotoxicity/mutagenicity of the mixtures. To verify any false negative response due to matrix effect, migrates were spiked with corresponding positive controls in parallel with the MMT and the DDR test. No matrix effect was observed in these experimental conditions.Show less >
Show more >Can's polyester coatings are intended to replace epoxy-phenolic ones due to rising safety concern regarding the potential release of bisphenol A under increased regulations and consumer pressure. In this study, hazard linked to the migration of non-intentionally added substances from a single polyester-coated tin plate (5 batches) to canned food has been studied. Migration tests were performed using acetonitrile (ACN) and ethanol (EtOH) 95 %. Non-targeted analyses by liquid chromatography–high-resolution mass spectrometry revealed the presence of four cyclic oligoesters classified as Cramer class III substances with an estimated exposure (calculated for French population only) below the threshold of toxicological concern value of 1.5 μg/kg b.w./day, suggesting a no safety concern. Moreover, migrates were tested using in vitro genotoxicity DNA damage response (DDR) test and mini mutagenicity test (MMT) with different strains of S. Typhimurium using direct incorporation (TA100, TA98, TA102, TA1537) and pre-incubation (TA100, TA98) methods. Samples were negative in both bioassays suggesting the absence of genotoxicity/mutagenicity of the mixtures. To verify any false negative response due to matrix effect, migrates were spiked with corresponding positive controls in parallel with the MMT and the DDR test. No matrix effect was observed in these experimental conditions.Show less >
Audience :
Internationale
Popular science :
Non
Administrative institution(s) :
Université de Lille
CHU Lille
Institut Pasteur de Lille
CHU Lille
Institut Pasteur de Lille
Submission date :
2024-05-06T21:19:27Z
2024-06-12T07:20:08Z
2024-06-12T07:20:08Z