Title :

Shaping the future of preclinical development of successful disease-modifying drugs against Alzheimer's disease: a systematic review of tau propagation models

Author(s) :

Basheer, N. [Auteur]
Slovak Academy of Sciences [SAS]
Buee, Luc [Auteur]
Lille Neurosciences & Cognition (LilNCog) - U 1172
Brion, J. P. [Auteur]
ULB Neuroscience Institute [Brussels] [UNI]
Smolek, T. [Auteur]
Slovak Academy of Sciences [SAS]
Muhammadi, M. K. [Auteur]
Slovak Academy of Sciences [SAS]
Hritz, J. [Auteur]
Masaryk University [Brno] [MUNI]
Hromadka, T. [Auteur]
Slovak Academy of Sciences [SAS]
Dewachter, I. [Auteur]
Hasselt University [UHasselt]
Wegmann, S. [Auteur]
German Research Center for Neurodegenerative Diseases - Deutsches Zentrum für Neurodegenerative Erkrankungen [DZNE]
Landrieu, Isabelle [Auteur]
Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement (RID-AGE) - U1167
Novak, P. [Auteur]
Slovak Academy of Sciences [SAS]
Mudher, A. [Auteur]
University of Southampton
Zilka, N. [Auteur]
Slovak Academy of Sciences [SAS]

Journal title :

Acta Neuropathologica Communications

Abbreviated title :

Acta Neuropathol Commun

Volume number :

12

Pages :

52

Publication date :

2024-04-10

ISSN :

2051-5960

English keyword(s) :

Tau protein
Propagation
Spreading
Aggregation
Neurofibrillary tangles
Animal models

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

The transcellular propagation of the aberrantly modified protein tau along the functional brain network is a key hallmark of Alzheimer's disease and related tauopathies. Inoculation-based tau propagation models can ...
Show more >The transcellular propagation of the aberrantly modified protein tau along the functional brain network is a key hallmark of Alzheimer's disease and related tauopathies. Inoculation-based tau propagation models can recapitulate the stereotypical spread of tau and reproduce various types of tau inclusions linked to specific tauopathy, albeit with varying degrees of fidelity. With this systematic review, we underscore the significance of judicious selection and meticulous functional, biochemical, and biophysical characterization of various tau inocula. Furthermore, we highlight the necessity of choosing suitable animal models and inoculation sites, along with the critical need for validation of fibrillary pathology using confirmatory staining, to accurately recapitulate disease-specific inclusions. As a practical guide, we put forth a framework for establishing a benchmark of inoculation-based tau propagation models that holds promise for use in preclinical testing of disease-modifying drugs.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Université de Lille
Inserm
CHU Lille

Collections :

• Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement (RID-AGE) - U1167
• Lille Neurosciences & Cognition (LilNCog) - U 1172

Submission date :

2024-05-06T22:35:01Z
2024-09-03T09:19:41Z