Titre :

Real-time mechanical characterization of DNA degradation under therapeutic X-rays and its theoretical modeling

Auteur(s) :

Perret, Grégoire [Auteur]
Physique - IEMN [PHYSIQUE - IEMN]
Lacornerie, Thomas [Auteur]
Centre Régional de Lutte contre le Cancer Oscar Lambret [Lille] [UNICANCER/Lille]
Manca, Fabio [Auteur]
Physique - IEMN [PHYSIQUE - IEMN]
Giordano, Stefano [Auteur]
Acoustique Impulsionnelle & Magnéto-Acoustique Non linéaire - Fluides, Interfaces Liquides & Micro-Systèmes - IEMN [AIMAN-FILMS - IEMN]
Kumemura, Momoko [Auteur]
Laboratory for Integrated Micro Mechatronics Systems [LIMMS]
Lafitte, Nicolas [Auteur]
Laboratory for Integrated Micro Mechatronics Systems [LIMMS]
Jalabert, Laurent [Auteur]
Laboratory for Integrated Micro Mechatronics Systems [LIMMS]
Tarhan, Mehmet [Auteur]
Laboratory for Integrated Micro Mechatronics Systems [LIMMS]
Lartigau, Eric [Auteur]
Centre Régional de Lutte contre le Cancer Oscar Lambret [Lille] [UNICANCER/Lille]
Cleri, Fabrizio [Auteur]
Physique - IEMN [PHYSIQUE - IEMN]
Fujita, Hiroyuki [Auteur]
Laboratory for Integrated Micro Mechatronics Systems [LIMMS]
Collard, Dominique [Auteur]
Laboratory for Integrated Micro Mechatronics Systems [LIMMS]

Titre de la revue :

Microsystems & Nanoengineering

Pagination :

16062

Éditeur :

Springer Nature

Date de publication :

2016-12-05

ISSN :

2055-7434

Mot(s)-clé(s) en anglais :

biomechanical measurements DNA damage microfluidic radiotherapy real-time Silicon Nanotweezers
biomechanical measurements
DNA damage
microfluidic
radiotherapy
real-time
Silicon Nanotweezers

Discipline(s) HAL :

Sciences de l'ingénieur [physics]
Sciences du Vivant [q-bio]

Résumé en anglais : [en]

Abstract The killing of tumor cells by ionizing radiation beams in cancer radiotherapy is currently based on a rather empirical understanding of the basic mechanisms and effectiveness of DNA damage by radiation. By contrast, ...
Lire la suite >Abstract The killing of tumor cells by ionizing radiation beams in cancer radiotherapy is currently based on a rather empirical understanding of the basic mechanisms and effectiveness of DNA damage by radiation. By contrast, the mechanical behaviour of DNA encompassing sequence sensitivity and elastic transitions to plastic responses is much better understood. A novel approach is proposed here based on a micromechanical Silicon Nanotweezers device. This instrument allows the detailed biomechanical characterization of a DNA bundle exposed to an ionizing radiation beam delivered here by a therapeutic linear particle accelerator (LINAC). The micromechanical device endures the harsh environment of radiation beams and still retains molecular-level detection accuracy. In this study, the first real-time observation of DNA damage by ionizing radiation is demonstrated. The DNA bundle degradation is detected by the micromechanical device as a reduction of the bundle stiffness, and a theoretical model provides an interpretation of the results. These first real-time observations pave the way for both fundamental and clinical studies of DNA degradation mechanisms under ionizing radiation for improved tumor treatment.Lire moins >

Langue :

Anglais

Comité de lecture :

Oui

Audience :

Internationale

Vulgarisation :

Non

Collections :

• Institut d'Électronique, de Microélectronique et de Nanotechnologie (IEMN) - UMR 8520

Source :

Harvested from HAL