Title :

Transitioning from Subtyping to Precision Medicine in Parkinson's Disease: A Purpose-Driven Approach

Author(s) :

Marras, Connie [Auteur]
University Health Network [Toronto, ON, Canada]
Toronto Western Hospital
Fereshtehnejad, Seyed-Mohammad [Auteur]
The Ottawa Hospital
University of Ottawa [Ottawa]
Berg, Daniela [Auteur]
Christian-Albrechts-Universität zu Kiel = Christian-Albrechts University of Kiel = Université Christian-Albrechts de Kiel [CAU]
Bohnen, Nicolaas I. [Auteur]
University of Michigan [Ann Arbor]
Dujardin, Kathy [Auteur]
Lille Neurosciences & Cognition (LilNCog) - U 1172
Erro, Roberto [Auteur]
Università degli Studi di Salerno = University of Salerno [UNISA]
Espay, Alberto J. [Auteur]
University of Cincinnati [UC]
Halliday, Glenda [Auteur]
The University of Sydney
Van Hilten, Jacobus J. [Auteur]
Leiden University Medical Center [LUMC]
Hu, Michele T. [Auteur]
Nuffield Department of Clinical Neurosciences [Oxford]
Jeon, Beomseok [Auteur]
Seoul National University Hospital
Klein, Christine [Auteur]
Universität zu Lübeck = University of Lübeck [Lübeck]
Leentjens, Albert F.G. [Auteur]
Maastricht University Medical Centre [MUMC]
Mollenhauer, Brit [Auteur]
Paracelsus-Elena-Klinik, Kassel, Germany.
Postuma, Ronald B. [Auteur]
McGill University = Université McGill [Montréal, Canada]
Rodríguez-Violante, Mayela [Auteur]
Simuni, Tanya [Auteur]
Feinberg School of Medicine [Northwestern University, Evanston] [[Northwestern University Medical School]]
Weintraub, Daniel [Auteur]
Perelman School of Medicine
Lawton, Michael [Auteur]
University of Bristol [Bristol]
Mestre, Tiago A. [Auteur]
Ottawa Hospital Research Institute [Ottawa] [OHRI]
University of Ottawa [Ottawa]

Journal title :

Movement Disorders

Abbreviated title :

Mov Disord

Volume number :

39

Pages :

462-471

Publisher :

Wiley

Publication date :

2024-01-20

ISSN :

1531-8257

English keyword(s) :

Parkinson's disease
heterogeneity
subtypes
purpose

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

The International Parkinson and Movement Disorder Society (MDS) created a task force (TF) to provide a critical overview of the Parkinson's disease (PD) subtyping field and develop a guidance on future research in PD ...
Show more >The International Parkinson and Movement Disorder Society (MDS) created a task force (TF) to provide a critical overview of the Parkinson's disease (PD) subtyping field and develop a guidance on future research in PD subtypes. Based on a literature review, we previously concluded that PD subtyping requires an ultimate alignment with principles of precision medicine, and consequently novel approaches were needed to describe heterogeneity at the individual patient level. In this manuscript, we present a novel purpose-driven framework for subtype research as a guidance to clinicians and researchers when proposing to develop, evaluate, or use PD subtypes. Using a formal consensus methodology, we determined that the key purposes of PD subtyping are: (1) to predict disease progression, for both the development of therapies (use in clinical trials) and prognosis counseling, (2) to predict response to treatments, and (3) to identify therapeutic targets for disease modification. For each purpose, we describe the desired product and the research required for its development. Given the current state of knowledge and data resources, we see purpose-driven subtyping as a pragmatic and necessary step on the way to precision medicine. © 2024 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.Show less >

Language :

Anglais

Peer reviewed article :

Oui

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Université de Lille
Inserm
CHU Lille

Collections :

• Lille Neurosciences & Cognition (LilNCog) - U 1172

Research team(s) :

Troubles cognitifs dégénératifs et vasculaires

Submission date :

2024-06-22T21:31:58Z
2025-02-28T10:02:02Z