Title :

Microglia maintain structural integrity during fetal brain morphogenesis.

Author(s) :

Lawrence, Akindé René [Auteur]
Canzi, Alice [Auteur]
Bridlance, Cécile [Auteur]
Olivié, Nicolas [Auteur]
Lansonneur, Claire [Auteur]
Catale, Clarissa [Auteur]
Pizzamiglio, Lara [Auteur]
Kloeckner, Benoit [Auteur]
Silvin, Aymeric [Auteur]
Munro, David A. D. [Auteur]
Fortoul, Aurélien [Auteur]
Boido, Davide [Auteur]
Zehani, Feriel [Auteur]
Cartonnet, Hugues [Auteur]
Viguier, Sarah [Auteur]
Oller, Guillaume [Auteur]
Squarzoni, Paola [Auteur]
Candat, Adrien [Auteur]
Helft, Julie [Auteur]
Allet, Cecile [Auteur]
Lille Neurosciences & Cognition - U 1172 [LilNCog]
Watrin, Françoise [Auteur]
Manent, Jean-Bernard [Auteur]
Paoletti, Pierre [Auteur]
Thieffry, Denis [Auteur]
Cantini, Laura [Auteur]
Pridans, Clare [Auteur]
Priller, Josef [Auteur]
Gélot, Antoinette [Auteur]
Giacobini, Paolo [Auteur]
Lille Neurosciences & Cognition (LilNCog) - U 1172
Ciobanu, Luisa [Auteur]
Ginhoux, Florent [Auteur]
Thion, Morgane Sonia [Auteur]
Lokmane, Ludmilla [Auteur]
Garel, Sonia [Auteur]

Journal title :

Cell

Abbreviated title :

Cell

Volume number :

187

Pages :

962-980.e19

Publication date :

2024-02-15

ISSN :

1097-4172

English keyword(s) :

microglia
microglial state
development
cerebral cortex
repair
cavity
Spp1
osteopontin
amygdala
corpus callosum

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Microglia (MG), the brain-resident macrophages, play major roles in health and disease via a diversity of cellular states. While embryonic MG display a large heterogeneity of cellular distribution and transcriptomic states, ...
Show more >Microglia (MG), the brain-resident macrophages, play major roles in health and disease via a diversity of cellular states. While embryonic MG display a large heterogeneity of cellular distribution and transcriptomic states, their functions remain poorly characterized. Here, we uncovered a role for MG in the maintenance of structural integrity at two fetal cortical boundaries. At these boundaries between structures that grow in distinct directions, embryonic MG accumulate, display a state resembling post-natal axon-tract-associated microglia (ATM) and prevent the progression of microcavities into large cavitary lesions, in part via a mechanism involving the ATM-factor Spp1. MG and Spp1 furthermore contribute to the rapid repair of lesions, collectively highlighting protective functions that preserve the fetal brain from physiological morphogenetic stress and injury. Our study thus highlights key major roles for embryonic MG and Spp1 in maintaining structural integrity during morphogenesis, with major implications for our understanding of MG functions and brain development.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Université de Lille
Inserm
CHU Lille

Collections :

• Lille Neurosciences & Cognition (LilNCog) - U 1172

Submission date :

2024-06-24T21:08:44Z
2025-01-07T14:28:10Z