Titre :

Preoperative 11C-Methionine PET-MRI in Pediatric Infratentorial Tumors

Auteur(s) :

Beuriat, Pierre-Aurélien [Auteur]
Université Claude Bernard Lyon 1 [UCBL]
Hôpital Femme Mère Enfant [CHU - HCL] [HFME]
Flaus, Anthime [Auteur]
Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center [CRNL]
Université Claude Bernard Lyon 1 [UCBL]
Hospices Civils de Lyon [HCL]
Portefaix, Aurélie [Auteur]
Hospices Civils de Lyon [HCL]
Szathmari, Alexandru [Auteur]
Hôpital Femme Mère Enfant [CHU - HCL] [HFME]
Janier, Marc [Auteur]
Université Claude Bernard Lyon 1 [UCBL]
Hospices Civils de Lyon [HCL]
Hermier, Marc [Auteur]
Hospices Civils de Lyon [HCL]
Lorthois-Ninou, Sylvie [Auteur]
Hôpital Femme Mère Enfant [CHU - HCL] [HFME]
Scheiber, Christian [Auteur]
Université Claude Bernard Lyon 1 [UCBL]
Hospices Civils de Lyon [HCL]
Isal, Sibel [Auteur]
Hospices Civils de Lyon [HCL]
Costes, Nicolas [Auteur]
Centre d'Etude et de Recherche Multimodal Et Pluridisciplinaire en imagerie du vivant [CERMEP - imagerie du vivant]
Merida, Inès [Auteur]
Centre d'Etude et de Recherche Multimodal Et Pluridisciplinaire en imagerie du vivant [CERMEP - imagerie du vivant]
Lancelot, Christine [Auteur]
Centre d'Etude et de Recherche Multimodal Et Pluridisciplinaire en imagerie du vivant [CERMEP - imagerie du vivant]
Vasiljevic, Alexandre [Auteur]
Université de Lyon
Leblond, Pierre [Auteur]
Centre Léon Bérard [Lyon]
Faure Conter, Cécile [Auteur]
Centre Léon Bérard [Lyon]
Saunier, Clarisse [Auteur]
Hospices Civils de Lyon [HCL]
Kassai, Behrouz [Auteur]
Hospices Civils de Lyon [HCL]
Vinchon, Matthieu [Auteur]
Hôpital Femme Mère Enfant [CHU - HCL] [HFME]
Di Rocco, Federico [Auteur]
Université Claude Bernard Lyon 1 [UCBL]
Hôpital Femme Mère Enfant [CHU - HCL] [HFME]
Mottolese, Carmine [Auteur]
Hôpital Femme Mère Enfant [CHU - HCL] [HFME]

Titre de la revue :

Clinical Nuclear Medicine

Nom court de la revue :

Clin Nucl Med

Numéro :

49

Pagination :

381-386

Éditeur :

Lippincott, Williams & Wilkins

Date de publication :

2024-05

ISSN :

1536-0229

Mot(s)-clé(s) en anglais :

amino acid PET
diffusion-weighted imaging
children
neuro-oncology
posterior fossa tumor
hybrid imaging
precision oncology

Discipline(s) HAL :

Sciences du Vivant [q-bio]

Résumé en anglais : [en]

Purpose MRI is the main imaging modality for pediatric brain tumors, but amino acid PET can provide additional information. Simultaneous PET-MRI acquisition allows to fully assess the tumor and lower the radiation exposure. ...
Lire la suite >Purpose MRI is the main imaging modality for pediatric brain tumors, but amino acid PET can provide additional information. Simultaneous PET-MRI acquisition allows to fully assess the tumor and lower the radiation exposure. Although symptomatic posterior fossa tumors are typically resected, the patient management is evolving and will benefit from an improved preoperative tumor characterization. We aimed to explore, in children with newly diagnosed posterior fossa tumor, the complementarity of the information provided by amino acid PET and MRI parameters and the correlation to histopathological results. Patients and Methods Children with a newly diagnosed posterior fossa tumor prospectively underwent a preoperative 11C-methionine (MET) PET-MRI. Images were assessed visually and semiquantitatively. Using correlation, minimum apparent diffusion coefficient (ADCmin) and contrast enhancement were compared with MET SUVmax. The diameter of the enhancing lesions was compared with metabolic tumoral volume. Lesions were classified according to the 2021 World Health Organization (WHO) classification. Results Ten children were included 4 pilocytic astrocytomas, 2 medulloblastomas, 1 ganglioglioma, 1 central nervous system embryonal tumor, and 1 schwannoma. All lesions showed visually increased MET uptake. A negative moderate correlation was found between ADCmin and SUVmax values (r = −0.39). Mean SUVmax was 3.8 (range, 3.3–4.2) in WHO grade 4 versus 2.5 (range, 1.7–3.0) in WHO grade 1 lesions. A positive moderate correlation was found between metabolic tumoral volume and diameter values (r = 0.34). There was no correlation between SUVmax and contrast enhancement intensity (r = −0.15). Conclusions Preoperative 11C-MET PET and MRI could provide complementary information to characterize pediatric infratentorial tumors.Lire moins >

Langue :

Anglais

Audience :

Internationale

Vulgarisation :

Non

Établissement(s) :

Université de Lille
CHU Lille

Collections :

• Autres travaux scientifiques

Date de dépôt :

2024-06-25T21:21:18Z
2024-07-05T13:21:11Z
2024-09-26T14:35:02Z