Title :

A Longitudinal Echocardiographic Analysis of Patients Treated Using the Repositionable and Fully Retrievable Lotus Valve: A Sub-Analysis of the RESPOND Study

Author(s) :

Soliman, Osama [Auteur]
Chang, Chun-Chin [Auteur]
Wohrle, Jochen [Auteur]
Hildick-Smith, David [Auteur]
Bleiziffer, Sabine [Auteur]
Blackman, Daniel J. [Auteur]
Abdel-Wahab, Mohamed [Auteur]
Modine, Thomas [Auteur]
Lille Neurosciences & Cognition (LilNCog) - U 1172
Nersesov, Andrey [Auteur]
Allocco, Dominic J. [Auteur]
Meredith, Ian T. [Auteur]
Falk, Volkmar [Auteur]
Van Mieghem, Nicolas M. [Auteur]

Journal title :

Structural Heart

Abbreviated title :

Struct. Heart-J. Heart Team

Volume number :

4

Pages :

26-33

Publication date :

2020-01

ISSN :

2474-8706

English keyword(s) :

Aortic valve implantation
aortic valve stenosis
echocardiography
paravalvular regurgitation
outcome

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Background The Lotus aortic valve system is a transcatheter heart valve (THV) designed with a seal to minimize paravalvular leak (PVL). We evaluated hemodynamic performance, PVL and ventricular function up to 1-year after ...
Show more >Background The Lotus aortic valve system is a transcatheter heart valve (THV) designed with a seal to minimize paravalvular leak (PVL). We evaluated hemodynamic performance, PVL and ventricular function up to 1-year after transcatheter aortic valve replacement (TAVR) using the Lotus THV in patients with severe aortic stenosis. Methods RESPOND was a prospective, single-arm, multicenter registry evaluating outcomes after Lotus TAVR in routine clinical practice. Core Laboratory adjudicated echocardiograms at baseline, discharge and 1-year were analyzed in a subgroup (N = 550) of patients with paired transthoracic echocardiography (TTE) at the 3 time points. Results Mean effective aortic valve orifice area (EOA) in cm2 increased from 0.74 ± 0.25 at baseline to 1.83 ± 0.46 at discharge and to 1.78 ± 0.45 at 1-year. Mean transvalvular gradient in mmHg was reduced from 38.7 ± 15.2 at baseline to 10.9 ± 4.2 at discharge and to 10.8 ± 5.1 at 1-year. VARC-2 hemodynamic success was achieved in 92% and 95% of patients at discharge and 1-year, respectively. Mild or more PVL was seen in 7.3% and 5.5% and moderate or more PVL was seen in 0.6% and 0.4% of the patients at discharge and 1-year, respectively. Stroke volume index (mL/m2) increased from 35 ± 10 at baseline to 40 ± 11 at discharge and to 41 ± 11 at 1-year (p < 0.001). Conclusions This RESPOND sub-study demonstrates persistently favorable hemodynamic performance and a low rate of PVL in unselected patients through 1-year in the largest Lotus-treated population to date.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Université de Lille
Inserm
CHU Lille

Collections :

• Lille Neurosciences & Cognition (LilNCog) - U 1172

Submission date :

2024-06-26T21:06:26Z
2025-01-23T13:25:10Z