Titre :

The admission level of CRP during cardiogenic shock is a strong independent risk marker of mortality

Auteur(s) :

Roubille, François [Auteur]
Centre Hospitalier Régional Universitaire [Montpellier] [CHRU Montpellier]
Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] [PhyMedExp]
Cherbi, Miloud [Auteur]
Centre Hospitalier Universitaire de Toulouse [CHU Toulouse]
Institut des Maladies Métaboliques et Casdiovasculaires [UPS/Inserm U1297 - I2MC]
Kalmanovich, Eran [Auteur]
Tel Aviv University [TAU]
Delbaere, Quentin [Auteur]
Centre Hospitalier Régional Universitaire [Montpellier] [CHRU Montpellier]
Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] [PhyMedExp]
Bonnefoy-Cudraz, Eric [Auteur]
Centre Hospitalier Lyon Sud [CHU - HCL] [CHLS]
Puymirat, Etienne [Auteur]
Université Paris Cité [UPCité]
Hôpital Européen Georges Pompidou [APHP] [HEGP]
Schurtz, Guillaume [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Facteurs de Risque et Déterminants Moléculaires des Maladies liées au Vieillissement - U 1167 [RID-AGE]
Gerbaud, Edouard [Auteur]
Hôpital Haut-Lévêque [CHU Bordeaux]
Centre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] [CRCTB]
Bonello, Laurent [Auteur]
Hôpital Nord [CHU - APHM]
Aix Marseille Université [AMU]
Lim, Pascal [Auteur]
Hôpital Henri Mondor
Leurent, Guillaume [Auteur]
Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou]
Laboratoire Traitement du Signal et de l'Image [LTSI]
Roubille, Camille [Auteur]
Centre Hospitalier Régional Universitaire [Montpellier] [CHRU Montpellier]
Delmas, Clément [Auteur]
CHU Montpellier = Montpellier University Hospital
Centre Hospitalier Universitaire de Toulouse [CHU Toulouse]
Institut des Maladies Métaboliques et Casdiovasculaires [UPS/Inserm U1297 - I2MC]
Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] [PhyMedExp]

Titre de la revue :

Scientific reports

Pagination :

16338

Éditeur :

Nature Publishing Group

Date de publication :

2024

ISSN :

2045-2322

Mot(s)-clé(s) en anglais :

CRP
Cardiogenic shock
Epidemiology
Infection
Inflammation
Mortality
Prognosis

Discipline(s) HAL :

Sciences du Vivant [q-bio]/Médecine humaine et pathologie/Cardiologie et système cardiovasculaire
Sciences du Vivant [q-bio]/Santé publique et épidémiologie

Résumé en anglais : [en]

Abstract Inflammatory processes are involved not only in coronary artery disease but also in heart failure (HF). Cardiogenic shock (CS) and septic shock are classically distinct although intricate relationships are frequent ...
Lire la suite >Abstract Inflammatory processes are involved not only in coronary artery disease but also in heart failure (HF). Cardiogenic shock (CS) and septic shock are classically distinct although intricate relationships are frequent in daily practice. The impact of admission inflammation in patients with CS is largely unknown. FRENSHOCK is a prospective registry including 772 CS patients from 49 centers. One-month and one-year mortalities were analyzed according to the level of C-reactive protein (CRP) at admission, adjusted on independent predictive factors. Within 406 patients included, 72.7% were male, and the mean age was 67.4 y ± 14.7. Four groups were defined, depending on the quartiles of CRP at admission. Q1 with a CRP < 8 mg/L, Q2: CRP was 8–28 mg/L, Q3: CRP was > 28–69 mg/L, and Q4: CRP was > 69 mg/L. The four groups did not differ regarding main baseline characteristics. However, group Q4 received more often antibiotics in 47.5%, norepinephrine in 66.3%, and needed more frequently respiratory support and renal replacement therapy. Whether at 1 month (P trend = 0.01) or 1 year (P trend < 0.01), a strong significant trend towards increased all-cause mortality was observed across CRP quartiles. Specifically, compared to the Q1 group, Q4 patients demonstrated a 2.2-fold higher mortality rate at 1-month (95% CI 1.23–3.97, p < 0.01), which persisted at 1-year, with a 2.14-fold increase in events (95% CI 1.43–3.22, p < 0.01). Admission CRP level is a strong independent predictor of mortality at 1 month and 1-year in CS. Specific approaches need to be developed to identify accurately patients in whom inflammatory processes are excessive and harmful, paving the way for innovative approaches in patients admitted for CS. NCT02703038.Lire moins >

Langue :

Anglais

Comité de lecture :

Oui

Audience :

Internationale

Vulgarisation :

Non

Collections :

• Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement (RID-AGE) - U1167

Source :

Harvested from HAL