Titre :

Targeting Oxidative Stress and Mitochondrial Dysfunction in the Treatment of Impaired Wound Healing: A Systematic Review

Auteur(s) :

Cano Sanchez, Mariola [Auteur]
Universitat de VIC, Universitat Central de Catalunyo = University of Vic-Central University of Catalonia [UVic-UCC]
Université des Antilles [UA]
Lancel, Steve [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Récepteurs nucléaires, maladies cardiovasculaires et diabète - U 1011 [RNMCD]
Boulanger, Eric [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Lille Inflammation Research International Center - U 995 [LIRIC]
Neviere, Remi [Auteur correspondant]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Lille Inflammation Research International Center - U 995 [LIRIC]
Université des Antilles [UA]

Titre de la revue :

ANTIOXIDANTS

Pagination :

98

Éditeur :

MDPI

Date de publication :

2018-07-24

ISSN :

2076-3921

Mot(s)-clé(s) en anglais :

wound healing
reactive oxygen species
mitochondria
advanced glycation end products
diabetes
inflammation
antioxidants

Discipline(s) HAL :

Sciences du Vivant [q-bio]

Résumé en anglais : [en]

Wound healing is a well-tuned biological process, which is achieved via consecutive and overlapping phases including hemostasis, inflammatory-related events, cell proliferation and tissue remodeling. Several factors can ...
Lire la suite >Wound healing is a well-tuned biological process, which is achieved via consecutive and overlapping phases including hemostasis, inflammatory-related events, cell proliferation and tissue remodeling. Several factors can impair wound healing such as oxygenation defects, aging, and stress as well as deleterious health conditions such as infection, diabetes, alcohol overuse, smoking and impaired nutritional status. Growing evidence suggests that reactive oxygen species (ROS) are crucial regulators of several phases of healing processes. ROS are centrally involved in all wound healing processes as low concentrations of ROS generation are required for the fight against invading microorganisms and cell survival signaling. Excessive production of ROS or impaired ROS detoxification causes oxidative damage, which is the main cause of non-healing chronic wounds. In this context, experimental and clinical studies have revealed that antioxidant and anti-inflammatory strategies have proven beneficial in the non-healing state. Among available antioxidant strategies, treatments using mitochondrial-targeted antioxidants are of particular interest. Specifically, mitochondrial-targeted peptides such as elamipretide have the potential to mitigate mitochondrial dysfunction and aberrant inflammatory response through activation of nucleotide-binding oligomerization domain (NOD)-like family receptors, such as the pyrin domain containing 3 (NLRP3) inflammasome, nuclear factor-kappa B (NF-κB) signaling pathway inhibition, and nuclear factor (erythroid-derived 2)-like 2 (Nrf2).Lire moins >

Langue :

Anglais

Comité de lecture :

Oui

Audience :

Internationale

Vulgarisation :

Non

Collections :

• Récepteurs nucléaires, Maladies Cardiovasculaires et Diabète (RNMCD) - U1011

Source :

Harvested from HAL