Titre :

Reappraising Cladophialophora bantiana phaeohyphomycosis in France: retrospective nation-based study

Auteur(s) :

Lortholary, Olivier [Auteur correspondant]
Hôpital Necker - Enfants Malades [AP-HP]
Imagine - Institut des maladies génétiques (IHU) [Imagine - U1163]
Mycologie translationnelle - Translational Mycology
Centre National de Référence Mycoses Invasives et Antifongiques - National Reference Center Invasive Mycoses & Antifungals [CNRMA]
Garcia-Hermoso, Dea [Auteur]
Mycologie translationnelle - Translational Mycology
Centre National de Référence Mycoses Invasives et Antifongiques - National Reference Center Invasive Mycoses & Antifungals [CNRMA]
Sturny-Leclère, Aude [Auteur]
Mycologie translationnelle - Translational Mycology
Centre National de Référence Mycoses Invasives et Antifongiques - National Reference Center Invasive Mycoses & Antifungals [CNRMA]
Sitbon, Karine [Auteur]
Mycologie translationnelle - Translational Mycology
Centre National de Référence Mycoses Invasives et Antifongiques - National Reference Center Invasive Mycoses & Antifungals [CNRMA]
Nourrisson, Céline [Auteur]
CHU Gabriel Montpied [Clermont-Ferrand]
Letscher-Bru, Valérie [Auteur]
Centre Hospitalier Universitaire [Strasbourg] [CHU Strasbourg]
Pathogens Host Arthropod Vectors Interfaces [PHAVI]
Desbois-Nogard, Nicole [Auteur]
Centre Hospitalier Universitaire de Martinique [Fort-de-France, Martinique] [CHU de Martinique]
Bani-Sadr, Ferouze [Auteur]
Hôpital universitaire Robert Debré [Reims] [CHU Reims]
Bastides, Frédéric [Auteur]
Hôpital Bretonneau
Bienvenu, Boris [Auteur]
Hôpital Saint-Joseph [Marseille]
Cordier, Camille [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Coste, Anne [Auteur]
Laboratoire de Traitement de l'Information Medicale [LaTIM]
Centre Hospitalier Régional Universitaire de Brest [CHRU Brest]
Danion, François [Auteur]
Immuno-Rhumatologie Moléculaire [IRM]
Les Hôpitaux Universitaires de Strasbourg [HUS]
Dégot, Tristan [Auteur]
Centre Hospitalier Universitaire [Strasbourg] [CHU Strasbourg]
Delarbre, David [Auteur]
Hopital d'instruction des armées Sainte-Anne [Toulon] [HIA]
Fekkar, Arnaud [Auteur]
Centre d'Immunologie et des Maladies Infectieuses [CIMI]
CHU Pitié-Salpêtrière [AP-HP]
Garcie, Christophe [Auteur]
Centre hospitalier de Pau
Garrouste, Cyril [Auteur]
CHU Gabriel Montpied [Clermont-Ferrand]
Gits-Muselli, Maud [Auteur]
Infection, Anti-microbiens, Modélisation, Evolution [IAME (UMR_S_1137 / U1137)]
Hôpital Robert Debré
Guemas, Emilie [Auteur]
Institut Toulousain des Maladies Infectieuses et Inflammatoires [Infinity]
Centre Hospitalier Universitaire de Toulouse [CHU Toulouse]
Huguenin, Antoine [Auteur]
Hôpital universitaire Robert Debré [Reims] [CHU Reims]
Epidémiosurveillance de protozooses à transmission alimentaire et vectorielle [ESCAPE]
Janvier, Frédéric [Auteur]
École du Val de Grâce [EVDG]
Hopital d'instruction des armées Sainte-Anne [Toulon] [HIA]
Kamar, Nassim [Auteur]
Institut Toulousain des Maladies Infectieuses et Inflammatoires [Infinity]
Kervinio, Cyril [Auteur]
Centre hospitalier de Pau
Le Gal, Solène [Auteur]
Infections Respiratoires Fongiques [IRF]
Centre Hospitalier Régional Universitaire de Brest [CHRU Brest]
Lesens, Olivier [Auteur]
CHU Gabriel Montpied [Clermont-Ferrand]
Machouart, Marie [Auteur]
Centre Hospitalier Régional Universitaire de Nancy [CHRU Nancy]
Stress, Immunité, Pathogènes [SIMPA]
Persat, Florence [Auteur]
Hospices Civils de Lyon [HCL]
Université Claude Bernard Lyon 1 [UCBL]
Picot, Sandrine [Auteur]
CHU Sud Saint Pierre [Ile de la Réunion]
Rouze, Anahita [Auteur]
Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576 [UGSF]
Ranque, Stéphane [Auteur]
Institut Hospitalier Universitaire Méditerranée Infection [IHU Marseille]
Ruch, Yvon [Auteur]
Les Hôpitaux Universitaires de Strasbourg [HUS]
Saada, Matthieu [Auteur]
Centre Hospitalier Saint Jean de Perpignan
Stabler, Sarah [Auteur]
Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL]
Alanio, Alexandre [Auteur]
Hopital Saint-Louis [AP-HP] [AP-HP]
Mycologie translationnelle - Translational Mycology
Centre National de Référence Mycoses Invasives et Antifongiques - National Reference Center Invasive Mycoses & Antifungals [CNRMA]
Lanternier, Fanny [Auteur]
Hôpital Necker - Enfants Malades [AP-HP]
Imagine - Institut des maladies génétiques (IHU) [Imagine - U1163]
Mycologie translationnelle - Translational Mycology
Centre National de Référence Mycoses Invasives et Antifongiques - National Reference Center Invasive Mycoses & Antifungals [CNRMA]
Desoubeaux, Guillaume [Auteur correspondant]
CHU Trousseau [Tours]

Titre de la revue :

The Lancet Microbe

Pagination :

100907

Éditeur :

Elsevier

Date de publication :

2024-11

ISSN :

2666-5247

Discipline(s) HAL :

Sciences du Vivant [q-bio]/Ecologie, Environnement/Santé
Sciences du Vivant [q-bio]/Médecine humaine et pathologie/Maladies infectieuses
Sciences du Vivant [q-bio]/Microbiologie et Parasitologie

Résumé en anglais : [en]

<div><p>Background Cladophialophora bantiana is one of the most virulent phaeohyphomycetes, typically causes non-angiogenic single (or sometimes multiple) cystic brain lesions, and has resulted in a mortality rate of up ...
Lire la suite ><div><p>Background Cladophialophora bantiana is one of the most virulent phaeohyphomycetes, typically causes non-angiogenic single (or sometimes multiple) cystic brain lesions, and has resulted in a mortality rate of up to 70%. Most C bantiana cases are described either in a series of isolated reports or in very small cohorts. The aim of this retrospective nationbased study was to share the data on C bantiana phaeohyphomycosis cases reported in France and French overseas territories over the past two decades to improve understanding of this disease.</p><p>Methods Patients with C bantiana infection were processed through the active surveillance programme of invasive fungal infections launched by the National Reference Center for Mycoses and Antifungals, Institut Pasteur (Paris, France), and the French Surveillance Network of Invasive Fungal Infections, which involved 29 hospitals from mainland France and overseas French territories. Only proven and probable cases of infection, according to the revised and updated consensus definitions from the European Organization for Research and Treatment of Cancer and Mycoses Study Group, were included in the study. Patients were diagnosed or confirmed, or both, using a polyphasic approach at the Institut Pasteur between 2002 and 2022. Patients were separated into two groups: those with CNS involvement and those with no CNS involvement. The primary outcome was the survival rate.</p><p>Findings A total of 23 patients with a C bantiana invasive infection were included during the study period (Jan 1, 2002, to Dec 31, 2022). The median age was 56 years in the CNS involvement group and 65 years in the non-CNS involvement group. Until 2021, the annual number of cases varied between zero and two, with six cases observed in 2022, the warmest year recorded in France since 1900. CNS involvement was observed in 15 (65%) patients, including three disseminated cases; skin and soft tissue involvement in seven (30%) patients and an isolated lung infection in one case. Diabetes was observed in five patients, and any immunodepression factor was observed in 14 (61%) of 23 patients. When considering only patients with CNS involvement, 9-month survival appeared higher in patients who underwent exeresis or large drainage (three [75%] of four patients vs three [27%] of 11 patients; p=0⋅24) and significantly higher in those treated for 2 or more weeks with triple antifungal therapy (liposomal amphotericin B plus posaconazole and flucytosine; seven [78%] of nine patients vs one [17%] of six patients; p=0⋅040). Two patients were treated with excision surgery alone (one patient with success, and the other patient lost to follow-up).</p><p>Interpretation This study shows that the clinical presentations and underlying medical conditions of C bantiana infections are more diverse than previously described. It also emphasises a significant difference in mortality rate between those with and without CNS involvement. The prognosis improved when surgery was performed and triple antifungal therapy was administered. Such rare and devastating invasive fungal infections should be managed by a multidisciplinary team.</p></div>Lire moins >

Langue :

Anglais

Comité de lecture :

Oui

Audience :

Internationale

Vulgarisation :

Non

Collections :

• Centre d'Infection et d'Immunité de Lille (CIIL) - U1019 - UMR 9017

Source :

Harvested from HAL