Title :

Resolution of MASH with no worsening of fibrosis after bariatric surgery improves 15-year survival: a prospective cohort study.

Author(s) :

Lassailly, Guillaume [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Caiazzo, Robert [Auteur]
Recherche translationnelle sur le diabète (RTD) - U1190
Goemans, Armelle [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Chetboun, Mikael [Auteur]
Recherche translationnelle sur le diabète - U 1190 [RTD]
Gnemmi, Viviane [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Labreuche, Julien [Auteur]
Service de Biostatistiques [CHRU Lille]
Baud, Gregory [Auteur]
Recherche translationnelle sur le diabète - U 1190 [RTD]
Verkindt, Hélène [Auteur]
Recherche translationnelle sur le diabète - U 1190 [RTD]
Marciniak, C. [Auteur]
Oukhouya-Daoud, Naima [Auteur]
Recherche translationnelle sur le diabète - U 1190 [RTD]
Ntandja-Wandji, Line-Carolle [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Ningarhari, Massih [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Leteurtre, Emmanuelle [Auteur]
Lille Neurosciences & Cognition - U 1172 [LilNCog]
Raverdy, Violeta [Auteur]
Recherche translationnelle sur le diabète - U 1190 [RTD]
Dharancy, Sebastien [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Louvet, Alexandre [Auteur]
Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286
Pattou, Francois [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Mathurin, Philippe [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]

Journal title :

Clinical Gastroenterology and Hepatology

Abbreviated title :

Clin Gastroenterol Hepatol

Publisher :

WB Saunders

Publication date :

2024-12-28

ISSN :

1542-7714

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Objectives Investigate the consequences of the histological progression of metabolically associated steatohepatitis (MASH) and fibrosis on long-term survival after bariatric surgery. Methods From 1994 to 2021, 3028 ...
Show more >Objectives Investigate the consequences of the histological progression of metabolically associated steatohepatitis (MASH) and fibrosis on long-term survival after bariatric surgery. Methods From 1994 to 2021, 3028 patients at the University Hospital of Lille were prospectively included. Baseline liver biopsies were systematically performed with proposed follow-up biopsies 1 year after surgery, mainly in MASH patients. We evaluated the association of the baseline and 1-year histological progression of MASH and fibrosis status and long-term survival using Cox regression models. Results At baseline, 2641 patients had a biopsy (89%), including 232 with MASH (8.7%) and 266 (10.8%) with significant fibrosis (grade F2-F4). The median follow-up was 10.1 years. At 1 year, 594 patients had qualitative paired biopsies. Survival was shorter at the 15-year follow-up in patients with baseline MASH, than in those without (hazard ratio (HR), 2.21; 95% confidence interval (CI), 1.38 to 3.53) and in F2-F4 than in F0-F1 (HR, 3.38; (95%CI, 2.24 to 5.10). At the 1-year landmark analysis, compared to patients without baseline MASH, mortality increased in those with persistent MASH and/or if fibrosis worsened (adjusted HR, 2.54 (95% CI, 1.06 to 6.10), but not if MASH resolved without the worsening of fibrosis (adjusted HR, 0.73 (95% CI, 0.28 to 1.87). Similarly, compared to patients without significant fibrosis at baseline, patients with persistent significant fibrosis had increased mortality (adjusted HR, 4.03 [95% CI, 1.86 to 8.72]) but not if fibrosis improved from F2-F4 to F0-F1 (adjusted HR; 1.49; 95%CI, 0.52 to 4.24). Conclusion Histological remission of MASH or significant fibrosis improves survival after bariatric surgery.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Université de Lille
Inserm
CHU Lille

Collections :

• Recherche translationnelle sur le diabète (RTD) - U1190

Submission date :

2024-12-31T22:02:38Z
2025-01-09T07:46:49Z