Title :

Abdominal PP meshes coated with functional core-sheath biodegradable nanofibers with anticoagulant and antibacterial properties

Author(s) :

Dufay, Malo [Auteur]
Unité Matériaux et Transformations (UMET) - UMR 8207
Jimenez, Maude [Auteur]
Unité Matériaux et Transformations (UMET) - UMR 8207
Casetta, Mathilde [Auteur]
Unité Matériaux et Transformations (UMET) - UMR 8207
Chai, Feng [Auteur]
Advanced Drug Delivery Systems (ADDS) - U1008
Blanchemain, Nicolas [Auteur]
Advanced Drug Delivery Systems (ADDS) - U1008
Maton, Mickael [Auteur]
Advanced Drug Delivery Systems (ADDS) - U1008
Cazaux, Frederic [Auteur]
Unité Matériaux et Transformations - UMR 8207 [UMET]
Bellayer, Séverine [Auteur]
Unité Matériaux et Transformations (UMET) - UMR 8207
Degoutin, Stephanie [Auteur]
Unité Matériaux et Transformations - UMR 8207 [UMET]

Journal title :

Biomaterials Advances

Abbreviated title :

Biomaterials Advances

Volume number :

169

Pages :

214163

Publisher :

Elsevier BV

Publication date :

2025-01-04

ISSN :

2772-9508

English keyword(s) :

Coaxial electrospinning
Abdominal hernia treatment
Postoperative adhesions
Anticoagulant activity
Antibacterial activity

HAL domain(s) :

Chimie/Matériaux
Chimie/Polymères

English abstract : [en]

Abdominal hernia repair is a common surgical procedure, involving in most cases the use of textile meshes providing a mechanical barrier to consolidate the damaged surrounding tissues and prevent the resurgence of the ...
Show more >Abdominal hernia repair is a common surgical procedure, involving in most cases the use of textile meshes providing a mechanical barrier to consolidate the damaged surrounding tissues and prevent the resurgence of the hernia. However, in more than half cases postoperative complications such as adhesions and infections occur at the surface of the mesh, leading to chronic pain for the patient and requiring the removal of the implant. One of the most promising strategies to reduce the risk of postoperative adhesions and infections is to add a physical barrier between the mesh and the abdominal walls. In this study, we propose a strategy to develop functional hernia meshes possessing anticoagulant and antibacterial activities depending on the side of the implant. Two bioactive polymers were synthetized: a polysulfonate (poly(2-acrylamido-2-methylpropane sulfonic acid), PAMPS) one for anticoagulant activity and a polymer bearing ternary amines (poly((2-tert-butylamino) ethyl methacrylate), PTBAEMA) for antibacterial activity. These polymers were used to produce core-sheath nanofibers thanks to coaxial electrospinning with poly(ɛ-caprolactone) (PCL) as core and the bioactive polymer as sheath. The electrospinning parameters were optimized in order to obtain defect-free nanofibrous coatings onto the mesh with improved stability in water. The core-sheath structure was investigated as well as the presence of the functional groups at the surface. The in vitro cytocompatibility, anticoagulant activity and antibacterial activity were evaluated and highlighted the high potential of these coatings for the simultaneous prevention of postoperative adhesions and infections.Show less >

Language :

Anglais

Peer reviewed article :

Oui

Audience :

Internationale

Popular science :

Non

ANR Project :

Implants anti-adhérents et antimicrobiens pour la chirurgie viscérale élaborés par plasma froid atmosphérique et electrospinning

Administrative institution(s) :

Université de Lille
CNRS
INRAE
ENSCL

Collections :

• Advanced Drug Delivery Systems (ADDS) - U1008
• Unité Matériaux et Transformations (UMET) - UMR 8207

Research team(s) :

Ingénierie des Systèmes Polymères
Procédés de Recyclage et de Fonctionnalisation (PReF)

Submission date :

2025-01-10T08:05:44Z
2025-01-10T09:43:45Z