Titre :

Signal propagation in the MAPK cascade: role of bistability and ultrasensitivity for a mixed problem

Auteur(s) :

Blossey, Ralf [Auteur]
Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576 [UGSF]
Institut de Recherche Interdisciplinaire [Villeneuve d'Ascq] [IRI]
Bodart, Jean-Francois [Auteur]
Laboratoire de Régulation des Signaux de Division
Devys, Anne [Auteur]
Laboratoire Paul Painlevé - UMR 8524 [LPP]
SImulations and Modeling for PArticles and Fluids [SIMPAF]
Goudon, Thierry [Auteur]
Laboratoire Paul Painlevé - UMR 8524 [LPP]
SImulations and Modeling for PArticles and Fluids [SIMPAF]
Lafitte, Pauline [Auteur]
Laboratoire Paul Painlevé - UMR 8524 [LPP]
SImulations and Modeling for PArticles and Fluids [SIMPAF]

Titre de la revue :

Journal of Mathematical Biology

Pagination :

1-39

Éditeur :

Springer

Date de publication :

2012

ISSN :

0303-6812

Mot(s)-clé(s) en anglais :

Reaction-Diffusion equations
Wave front
Cell signalling
MAPK cascade

Discipline(s) HAL :

Mathématiques [math]/Equations aux dérivées partielles [math.AP]

Résumé en anglais : [en]

The MAPK signaling cascade is nowadays understood as a network module highly conserved across species. Its main function is to transfer a signal arriving at the plasma membrane to the cellular interior, the nucleus. Current ...
Lire la suite >The MAPK signaling cascade is nowadays understood as a network module highly conserved across species. Its main function is to transfer a signal arriving at the plasma membrane to the cellular interior, the nucleus. Current understanding of 'how' this is achieved involve the notions of ultrasensitivity and bistability which relate to the nonlinear dynamics of the biochemical network, ignoring spatial aspects. Much less, indeed, is so far known about the propagation of the signal through the cytoplasm. In this work we formulate, starting from a Michaelis-Menten model for the MAPK cascade in {\it Xenopus} oocytes, a reaction-diffusion model of the cascade. We study this model in one space dimension. Basing ourselves on previous general results on reaction diffusion models, we particularly study for our model the conditions for signal propagation. We show that the existence of a propagating front depends sensitively on the initial and boundary conditions at the plasma membrane. Possible biological consequences of this finding are discussed.Lire moins >

Langue :

Anglais

Comité de lecture :

Oui

Audience :

Internationale

Vulgarisation :

Non

Collections :

• Laboratoire Paul Painlevé - UMR 8524

Source :

Harvested from HAL